Staphylococcus aureus is an opportunistic pathogen that infects practically every body site despite differences in nutritional environment, immune milieu, and mode of inoculation. S. aureus abscesses are pathophysiological structures wherein host-derived extracellular matrix and immune cells form layers surrounding a S. aureus colony. Staphylococcal abscess communities seed staphylococcal abscesses, which are associated with worse S. aureus infection outcomes. Abscesses are also an example of the host–S. aureus interface, wherein host and pathogen adaptations define the spatial and temporal features of pathogenesis as well as the outcomes of infection. This review discusses recent discoveries in abscess formation made across organ systems and highlights findings involving host and pathogen determinants of abscess formation that improve our understanding of S. aureus pathogenesis.

Yang et al. summarize that Klebsiella pneumoniae affects infectious and non-infectious disease via gut colonization; commensals provide colonization resistance, but K. pneumoniae adapts via multiple m...

Enterococcus lactis, a recently established species that was previously classified as Enterococcus faecium clade B. Given its recent taxonomic classification, studies on this bacterium are scarce, an...

The cell death effector Gasdermin A is only known to be activated by Streptococcus pyogenes. This work discovers a mechanism for its activation by Staphylococcus aureus, and shows a conserved role in ...

Molecular biology; Microbiology; Cell biology

Abstract. The human nasal microbiome can serve as a reservoir for pathogens. In particular, the opportunistic pathogen Staphylococcus aureus can be a membe

Rifampicin is more effective against biofilm infections because it targets biofilm-forming mutants that are highly resistant to other antibiotics.

The authors developed a screen to find compounds that modulate intracellular Staphylococcus aureus metabolism and discovered KL1, which sensitizes persisters to antibiotics by reversing host-induced tolerance.

Nasal colonization by Staphylococcus aureus is linked with depression in a human cohort and shown in a mouse model to cause decreased serotonin and dopamine in the brain.

Inflammatory bowel disease (IBD) is a chronic immune-mediated condition. This study presents a drug-free treatment strategy for IBD that targets bacterial adhesion, utilizing mannan oligosaccharide-lo...

Wissenschaft/Forschung in Jena

This study reveals how the pathogen Staphylococcus aureus adapts to the lung microenvironment, rich in host metabolites fumarate and itaconate, by using a key enzyme, FumC, to support its metabolic fi...

When talking about Staphylococcus aureus, one usually has in mind the diseases that can be caused by this bacterium, ranging from mild skin and soft tissue infections, such as abscesses and furuncles,...

Staphylococcus haemolyticus is an important cause of sepsis in preterm infants, with gut colonization being recognized as a risk factor for infection. To better understand the diversity of S. haemo...

Everyday actions such as eating, tooth brushing or applying cosmetics inherently modulate our microbiome. Advances in sequencing technologies now facilitate detailed microbial profiling, driving inten...

Rainbow trout with depleted secretory IgM reveal interesting insights into the elusive role of this immunoglobulin in maintaining gut microbiota.

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Microbial pathogens continue to plague human health and develop resistance to our current frontline treatments. Over the last few decades, there has b…

This narrative review summarizes current evidence on the epidemiology, pathophysiology, clinical presentation, diagnosis, and treatment of Staphylococcus aureus bacteremia.

A multi-omics approach reveals host–microbiome interactions in aging in mice.

The skin acts as a barrier against external threats and plays an important role in tissue repair. Skin cells, including keratinocytes, sense microbe-associated molecular pattern molecules released by ...

Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...

Reduced dietary fibre together with mutations in the host mismatch repair machinery promote colon carcinogenesis by increasing inflammation, nitrate-fuelled growth of colibactin-producing Escherichia ...

The gut microbiota of infants harbours a higher proportion of antibiotic resistance genes (ARGs) compared to adults, even in infants never exposed to …

Bacteriophages are crucial in bacterial communities and can be used for therapy of multidrug-resistant pathogens such as Staphylococcus aureus. Howeve…

The ubiquitous gram-negative bacterium Pseudomonas aeruginosa is categorized as an ESKAPE pathogen (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudom...