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Christiane Wolz

@wolzc.bsky.social

215 followers 200 following 0 posts

Microbiology University Tübingen

Reposted by Christiane Wolz

Cluster of Excellence CMFI @cmfi.bsky.social · 31/03/2025

Study shows that (p)ppGpp-controlled GTP homeostasis is essential for maintaining the proton motive force. This ensures #bacterial survival and #antibiotic tolerance. Study by Andrea Salzer et al. points to new approaches to fight persistent infections: shorturl.at/HtJ6N @wolzc.bsky.social

Fig 9 from original publication: Bacterial culturability in the stationary phase is dependent on (p)ppGpp-driven GTP depletion. Uncontrolled, high levels of GTP (low ATP) in the (p)ppGpp0 mutant resulted in membrane disorder and decreased PMF. The lower PMF could at least in part be linked to transcriptional downregulation of nucleotide-sensitive genes of the respiratory chain. Maintenance of respiratory chain activity under (p)ppGpp positive/low GTP conditions likely accounts for the observed tolerance of stationary phase cells to bactericidal antibiotics.

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Reposted by Christiane Wolz

Andreas Peschel @andreaspeschel.bsky.social · 03/03/2025

By Janes Krusche @jkrusche.bsky.social. Christian Beck, @dger.bsky.social @wolzc.bsky.social et al @cmfi.bsky.social @spp2330.bsky.social @dzif.bsky.social

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Reposted by Christiane Wolz

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 07/02/2024

(p)ppGpp-mediated GTP homeostasis ensures the survival and antibiotic tolerance of Staphylococcus aureus during starvation by preserving the proton motive force www.biorxiv.org/content/10.1101/202…

biorxiv.org

(p)ppGpp-mediated GTP homeostasis ensures the survival and antibiotic tolerance of Staphylococcus aureus during starvation by preserving the proton motive force https://www.biorxiv.org/content/10.1101/2024.02.06.579068v1

Upon nutrient limitation bacteria enter a nongrowing state, which allow bacterial survival and antib

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Reposted by Christiane Wolz

Andreas Peschel @andreaspeschel.bsky.social · 01/11/2023

How S. aureus interacts with the endothelium in endovascular infections @cmfi.bsky.social @wolzc.bsky.social Wall Teichoic Acid Mediates Staphylococcus aureus Binding to Endothelial Cells via the Scavenger Receptor LOX-1 | ACS Infectious Diseases pubs.acs.org/doi/10.1021/...

pubs.acs.org

Wall Teichoic Acid Mediates Staphylococcus aureus Binding to Endothelial Cells via the Scavenger Rec...

The success of Staphylococcus aureus as a major cause for endovascular infections depends on effective interactions with blood-vessel walls. We have previously shown that S. aureus uses its wall teich...

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Reposted by Christiane Wolz

Andreas Peschel @andreaspeschel.bsky.social · 21/10/2023

Nasal IgA governs governs if respiratory colonizers and pathogens can establish. Read how vastly IgA levels vary affecting microbiome members differently. #S.aureus uses protein A to accumulate IgA. By Rob van Dalen, @Ah_M_Elsherbini... @CoE_CMFI @DZIF_ doi.org/10.1186/s40168…

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