Although dementias primarily affect memory, they also disrupt our closest social relationships, resulting in elevated caregiver burden and worse patient outcomes. However, the mechanistic study of how...

Molecular Psychiatry - Pathogenic tau in the mouse locus coeruleus produces noradrenergic hyperactivity and neuropsychiatric phenotypes reminiscent of early Alzheimer’s disease

Read the latest articles of Addiction Neuroscience at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature

Neuropsychopharmacology - The role of spousal relationships in shaping clinical trajectories during aging

Neuropsychopharmacology - The role of spousal relationships in shaping clinical trajectories during aging

Molecular Psychiatry - A new hope: locus coeruleus-norepinephrine system at the nexus of neuropsychiatric symptoms

Optogenetics and functional magnetic resonance imaging (fMRI) are two tools that have become indispensable for neuroscientists, though they have traditionally been used to ask distinct questions regar...

INTRODUCTION In murine models of Alzheimer's disease (AD), lesioning the locus coeruleus–norepinephrine (LC-NE) system with DSP-4 exacerbates AD-like neuropathology and cognitive impairment. However...

Neuromodulatory subcortical systems (NSSs) are uniquely susceptible to dementia-related pathology, leading to frequent molecular and behavioral impairments associated with altered function of these n...

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Ogg et al. use in vivo imaging techniques to record activity in the locus coeruleus (LC) and the orbitofrontal cortex (OFC) during a reversal learning task in freely moving rodents. They show that man...