Neuropsychopharmacology - Estrous cycle stage gates the effect of stress on reward learning

Subchronic variable stress, a paradigm shown to have divergent behavioral effects in males and females, induces shared and distinct physiological adaptations in the VTA. While both males and females ...

Reelin is a critical mechanistic link between neuronal activation and cocaine-induced behavioral adaptations.

In mice, prolonged consumption of a high-fat diet decreases interest in calorie-rich foods as a result of reduced neurotensin expression and signalling, which uncouples hedonic feeding behaviour linke...

Adaptive decision-making often requires an understanding of our agency in a situation; however, chronic stress can disrupt agency and promote inflexible, habitual behaviour by turning off a brain path...

After decades of research, Vertex Pharmaceuticals now has an approved pain medication. Can one of the world’s most powerful biotechs contend with a healthcare system that’s long favored opioids?

The 5xFAD transgenic model, popular in Alzheimer’s disease research, exhibits varying cerebral plaque burden depending on the parental source of the transgene. Mice inheriting the transgene paternally...

The ventral tegmental area (VTA) is a critical component of brain reward circuitry that influences motivation, learning, and emotional regulation. Alt…

Too much heavy drinking during your college years can have a lasting and devastating impact on the neurons in your brain, even if you stop drinking after this period of your life.