Soil bacteria colonize plants without causing visible disease, yet many suppress host growth. The prevalence and evolutionary reach of this cryptic inhibition are unknown, because phenotyping hundreds...

Across eukaryotes, the nuclear envelope exhibits distinct remodelling strategies during mitosis: complete breakdown (open mitosis), partial disruption (intermediate), or full retention (closed). Howev...

The 26S proteasome is essential for proteostasis and constitutes one of the most conserved molecular machineries in eukaryotes. Its homeostasis is maintained by a mechanistically conserved feedback lo...

The 26S proteasome is essential for proteostasis and constitutes one of the most conserved molecular machineries in eukaryotes. Its homeostasis is maintained by a mechanistically conserved feedback lo...

Impairments in intracellular quality-control mechanisms, including autophagy, affect neuronal integrity and function. Despite numerous studies aimed at slowing neuronal deterioration, it remains uncle...

Effective plant immunity requires precise spatial coordination of immune responses across cell-types to restrict pathogens while preventing tissue damage, yet the intracellular pathways that organize ...

Transcription in chloroplasts depends on the Plastid-Encoded RNA polymerase (PEP), a bacterial-derived enzyme whose catalytic core remains encoded by the highly reduced genome inherited from the cyano...

Plants and animals respond to pathogen attack by mounting innate immune responses that require intracellular nucleotide-binding leucine-rich repeat (NLR) proteins. These immune receptors detect pathog...

Helitrons are a recently identified category of transposons. This study reveals that heat stress combined with reduced DNA methylation can mobilize a Helitron family in wheat. Its mobilization is gene...

RNA viruses co-opt host endomembranes to form replication complexes, often triggering cellular stress and immune responses. Here, we show that Arabidopsis thaliana activates selective autophagy to res...

Noboru Mizushima is Professor of Biochemistry and Molecular Biology at the University of Tokyo, Japan, where he runs a laboratory studying the mechanisms and physiological functions of autophagy and o...

Cytokinesis is a key process in the development of multicellular organisms, through both formative and proliferative divisions. In land plants, successful cytokinesis requires precise targeting of Gol...

Understanding how positional information within plant tissues shapes developmental programs in real time has long remained a challenge due to technica…

From the dating of 132 ancient whole-genome duplication events across 470 angiosperms, paleopolyploidization events cluster around pivotal periods of environmental upheaval and extinction, notably the...

Plants carry out mammalian-like steroidogenesis that generates endocrine-mimetic cardenolides.

The ubiquitin system is a central regulator of plant immunity, with E3 ligases conferring substrate specificity across diverse signaling pathways. This review synthesizes structural and mechanistic i...

Protein N-terminal acetylation profoundly influences protein fate. Here, the authors establish NatB as a central regulator of the interplay between ubiquitin–proteasome system and autophagy, and highl...

Tryptamine psychedelics from plants, fungi, and toads are produced in planta through cross-kingdom pathway reconstruction.

Lennartz et al. introduce a correlative light and electron microscopy workflow, Lipid-CLEM, combining near-native lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively a...

They are so far out of sight for us, creatures of the upper world, that we don’t readily think of them. But as soon as we do, as soon as we plunge the mind into the cold dark hummus to which …