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Nitzan Shabek

@shabeklab.bsky.social
1K followers 931 following 18 posts

Prof. @UC Davis ∙structural biologist⚛︎ ubiquitin system aficionado ✾ signaling & sensing mechanisms in plants🌱in vivo interacomes 🎸dad of 2 shabek-lab.ucdavis.edu

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Reposted by Nitzan Shabek
Titus Brown @titus.idyll.org · 23/09/2026
Assistant Professor of Food Microbiology position here at UC Davis (tenure track) - apply by Dec 1, 2026!
recruit.ucdavis.edu
Assistant Professor of Food Microbiology
University of California, Davis is hiring. Apply now!
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Nitzan Shabek @shabeklab.bsky.social · 22/09/2026
Check out our new review @theplantcell.bsky.social A collaborative effort with Yangnan Gu and Shou-Ling Xu, and members of our labs, bringing together practical lessons for designing, executing, and interpreting proximity-labeling proteomics in plants: academic.oup.com/plcell/artic...
academic.oup.com
Best practices for biotin ligase–based proximity labeling proteomics in plant systems
Abstract. Proximity labeling (PL) proteomics, primarily powered by engineered biotin ligases such as BioID and TurboID, has emerged as a transformative app
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Nitzan Shabek @shabeklab.bsky.social · 20/08/2026
🔥check out our latest @jxbotany.bsky.social: From signalling to catabolism: terminal tails in plant hormone regulation. Hormone catabolism is no passive cleanup, but highly regulated. How do structural plasticity & the ubiquitin system tune hormone deactivation? academic.oup.com/jxb/article/...
academic.oup.com
From signalling to catabolism: terminal tails in plant hormone regulation
Hormone catabolism is emerging as an active layer of plant signalling, with strigolactone and salicylic acid pathways showing how terminal protein regions
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Nitzan Shabek @shabeklab.bsky.social · 05/08/2026
check out our latest review. Beyond prediction: Why experimental structural biology remains essential in plants. www.sciencedirect.com/science/arti...
sciencedirect.com
Beyond prediction: Why experimental structural biology remains essential in plants
Structural biology is undergoing a transformative era driven by advances in artificial intelligence (AI)-based protein structure prediction and cryo-e…
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Reposted by Nitzan Shabek
UC Davis Egghead @ucdavis-egghead.bsky.social · 04/05/2026
While plants don't get headaches, they do use salicylic acid to fight infections. But too much stunts growth. A new UC Davis study shows how plants regulate this important hormone www.ucdavis.edu/news/plants-...
ucdavis.edu
Plants Walk a Fine Line Between Growth and Defense
Salicylic acid, the active molecule in aspirin and some acne medications, is a hormone in plants that is essential for immunity, but it’s a double-edged sword: Too much can cause autoimmunity and stun...
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Nitzan Shabek @shabeklab.bsky.social · 22/04/2026
🔥our latest study is now online @natcomms.nature.com we found that the salicylic acid catabolic enzymes DMR6/DLO1 are controlled by the ubiquitin system. SA modulates their turnover, revealing a regulatory circuit linking hormone metabolism to immune balance. www.nature.com/articles/s41...
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Gitta Coaker @gittacoaker.bsky.social · 18/04/2026
We are hiring! We’re excited to recruit a postdoc to our lab at UC Davis to work on plant immune engineering and single-cell analyses of plant pathogen interactions. Apply by June 1. Please repost. www.coakerlab.org/postdoctoral...
Postdoctoral Scholar position in the Coaker group
University of California, Davis
We are seeking a Postdoctoral Scholar to join our research program focused on immune receptor engineering and spatial analyses of plant pathogens interactions using computational and imaging approaches. The position will involve integration of molecular, imaging, and computational approaches. Relevant publications from the laboratory include Nature Plants (2025, PMID: 40721669), Proceedings of the National Academy of Sciences (2024, PMID: 38814867), and Cell Reports (2023, PMID: 37342910). https://www.coakerlab.org/
Qualifications:
•	Ph.D. in plant biology, molecular biology, genetics, computational biology, or a related field
•	Strong background in genomics and/or computational biology 
•	First author publications in peer-reviewed journals
•	Ability to work both independently and collaboratively in a multidisciplinary environment
•	Experience in plant innate immunity is preferred

Application Instructions:
The position is initially available for two years, with the possibility of extension based on performance and funding. Salary is based on the University of California postdoctoral salary scale (https://www.ucop.edu/academic-personnel-programs/_files/2025-26/represented-oct-2025-scales/t23.pdf). The salary range for this position is $69,073-$82,836 US Dollars/year. 
Review of applications will begin June 1, 2026 and will continue until the position is filled.
Please submit a CV, a brief statement of research interests (~1 page), and contact information for three references to glcoaker@ucdavis.edu. The research statement should describe your previous work, how your expertise aligns with ongoing research in the lab, and potential future research directions.
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Nitzan Shabek @shabeklab.bsky.social · 07/04/2026
Excited to share our latest review on ubiquitin ligases in plant immunity onlinelibrary.wiley.com/doi/epdf/10....
onlinelibrary.wiley.com
Ubiquitin ligases in plant immunity: structural mechanisms and signaling
The ubiquitin system is a central regulator of plant immunity, with E3 ligases conferring substrate specificity across diverse signaling pathways. This review synthesizes structural and mechanistic i...
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Nitzan Shabek @shabeklab.bsky.social · 25/03/2026
Humbled and honored to receive the UC Davis Distinguished Teaching Award 🏅 Beyond our research mission, education & mentoring are at the core of what we do @ucdavis.bsky.social & I’m grateful for the opportunity to teach such engaged & motivated students www.ucdavis.edu/news/senate-...
ucdavis.edu
Senate and Federation Honor ‘Transformative,’ ‘Inspiring’ Academics
The Academic Senate and Federation have announced their top awards, comprising 15 academics across various disciplines throughout the university.The awards cite the impact these academics have had on ...
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Nitzan Shabek @shabeklab.bsky.social · 06/03/2026
Excited to share our new review, now online @annualreviews.bsky.social : Structural Insights into Plant Hormone-Sensing Mechanisms www.annualreviews.org/content/jour...
annualreviews.org
Structural Insights into Plant Hormone-Sensing Mechanisms
Plant hormones are essential small molecules that regulate plant growth, development, and systemic responses to environmental stimuli. These processes are mediated by complex signaling networks involv...
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Reposted by Nitzan Shabek
Crystal Rogers, PhD @rogerslabucd.bsky.social · 23/01/2026
UC Davis has a Designated Emphasis in Biotechnology that allows students to engage with industry professionals deb.ucdavis.edu. We also have shadowing programs that allow grad students to interact with and advise leadership grad.ucdavis.edu/CGPSA.
deb.ucdavis.edu
Designated Emphasis in Biotechnology (DEB)
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Reposted by Nitzan Shabek
Nitzan Shabek @shabeklab.bsky.social · 25/12/2025
Excited to share our latest work to close out 2025: Dynamic ASK1 proximity networks uncover SCF-dependent and noncanonical roles in ABA and drought adaptation🌱 With @justinwwalley.bsky.social , we map how ASK1/SKP1 dynamically rewires protein networks during stress www.biorxiv.org/content/10.6...
biorxiv.org
Dynamic ASK1 proximity networks uncover SCF-dependent and noncanonical roles in ABA and drought adaptation
Plants rely on rapid proteome remodeling to withstand fluctuating environmental conditions, yet how the ubiquitin system dynamically coordinates these multilayered responses remains unclear. Here we d...
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Nitzan Shabek @shabeklab.bsky.social · 25/12/2025
Excited to share our latest work to close out 2025: Dynamic ASK1 proximity networks uncover SCF-dependent and noncanonical roles in ABA and drought adaptation🌱 With @justinwwalley.bsky.social , we map how ASK1/SKP1 dynamically rewires protein networks during stress www.biorxiv.org/content/10.6...
biorxiv.org
Dynamic ASK1 proximity networks uncover SCF-dependent and noncanonical roles in ABA and drought adaptation
Plants rely on rapid proteome remodeling to withstand fluctuating environmental conditions, yet how the ubiquitin system dynamically coordinates these multilayered responses remains unclear. Here we d...
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Reposted by Nitzan Shabek
The Plant Journal @theplantjournal.bsky.social · 16/12/2025
📚New 𝐅𝐨𝐜𝐮𝐬𝐞𝐝 𝐑𝐞𝐯𝐢𝐞𝐰: 🌱An emerging signaling hub: KAI2 at the nexus of phytohormone networks🌱 Highlights KAI2 as an integrator of plant hormone signaling, despite its unknown endogenous ligand. ✍️By Jacob Moe-Lange and Nitzan Shabek @shabeklab.bsky.social Read it here👉 doi.org/10.1111/tpj....
doi.org
An emerging signaling hub: KAI2 at the nexus of phytohormone networks
KAI2 signaling has emerged as a central integrator of plant hormonal networks, coordinating growth and stress responses despite the continued mystery surrounding its endogenous ligand. This review sy...
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Reposted by Nitzan Shabek
Lior Tal @solyclior.bsky.social · 10/12/2025
Was super excited to host @shabeklab.bsky.social in Tel Aviv for the first time since starting my position here and to hear all about the cutting-edge science his lab has been up to since we parted ways! Truly inspiring talk. ✨🤩💪🌱 @ucdavis.bsky.social @telavivuni.bsky.social
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Nitzan Shabek @shabeklab.bsky.social · 01/12/2025
An emerging signaling hub: KAI2 at the nexus of phytohormone networks onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
An emerging signaling hub: KAI2 at the nexus of phytohormone networks
KAI2 signaling has emerged as a central integrator of plant hormonal networks, coordinating growth and stress responses despite the continued mystery surrounding its endogenous ligand. This review sy...
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Nitzan Shabek @shabeklab.bsky.social · 19/05/2025
excited to be part of this study published @pnas.org led by the wonderful Caroline Gutjahr 👏revealing how the GRAS protein RAM1 partners with WRI transcription factors to regulate genes essential for arbuscule formation & nutrient exchange in plant-fungal symbiosis www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Reposted by Nitzan Shabek
Şuayb Üstün @suaybuestuen.bsky.social · 05/03/2025
Wow! The Proteasome generates antimicrobial peptides that directly affect bacterial membranes #proteostasis www.nature.com/articles/s41...
nature.com
Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature
Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...
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Reposted by Nitzan Shabek
Karolin Luger @nucleosomepolice.bsky.social · 01/03/2025
🧪what with the demolition of #NIH funded #research, where, dare I ask, are our friends from #bigpharma? y'all good? mooched enough off of public-access NIH-funded research? Stocked up with PhD level scientists who were trained on NIH training grants to tide you over until Academia comes back?
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Nitzan Shabek @shabeklab.bsky.social · 18/01/2025
Super excited to contribute to this amazing work on the evolution of interorganismal strigolactone biosynthesis www.science.org/doi/10.1126/...
science.org
Evolution of interorganismal strigolactone biosynthesis in seed plants
Strigolactones (SLs) are methylbutenolide molecules derived from β-carotene through an intermediate carlactonoic acid (CLA). Canonical SLs act as signals to microbes and plants, whereas noncanonical S...
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Reposted by Nitzan Shabek
Rashmi Agrata @rashmiagrata.bsky.social · 17/01/2025
New to #ubiquitin? Been with it for a while? Either way this review may be for you 🤩 Excited to share our review article in @molcell.bsky.social, diving deep into everything #ubiquitin Read here 👉: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... @cellpress.bsky.social @wehi-research.bsky.social
'Ubiquitin Lysine-Linkages' from the review 'Ubiquitin: a structural perspective' in Molecular Cell
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Reposted by Nitzan Shabek
New Phytologist @newphyt.bsky.social · 21/11/2024
🆕 Our Latest Issue is online now! 📚 nph.onlinelibrary.wiley.com/toc/14698137... Highlights: 🌱 Announcing the 2024 Tansley Medal winner 🌱 Unravelling plant centromeres 🌱 Is auxin the key to improve crop nitrogen efficiency? 🌱 Vegetation responses to moisture conditions
nph.onlinelibrary.wiley.com
New Phytologist: Vol 244, No 6
<em>New Phytologist</em> is an international journal owned by the New Phytologist Foundation publishing original research in plant science and its applications.
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Nitzan Shabek @shabeklab.bsky.social · 21/11/2024
Excited to share that our research on the SCF E3 ubiquitin ligase interactome in plants is now published in New Phytologist and featured as the cover of the current issue! 🌱 @newphyt.bsky.social #ubiquitin #proteostasis nph.onlinelibrary.wiley.com/share/CA8XRQ...
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Reposted by Nitzan Shabek
Şuayb Üstün @suaybuestuen.bsky.social · 20/11/2024
I made a starter pack for the plant proteostasis community - please let me know if I missed someone to add new members #proteostasis
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Reposted by Nitzan Shabek
2025 International Plant Growth Substance Association (IPGSA) @ipgsa2025.bsky.social · 20/11/2024
The email announcement of International Plant Growth Substances Association (IPGSA) Conference in 2025 in Fort Collins, Colorado, USA is just out! Please spread the word of what will be a very exciting conference in a beautiful place. #IPGSA2025
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Justin Walley @justinwwalley.bsky.social · 10/11/2024
Final version of or single-cell proteomics paper is now published in the New Phytologist December issue! @dormichicken.bsky.social nph.onlinelibrary.wiley.com/doi/10.1111/...
nph.onlinelibrary.wiley.com
Single‐cell proteomics differentiates Arabidopsis root cell types
See also the Commentary on this article by van Schie & Weijers, 244: 1678–1680.
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Reposted by Nitzan Shabek
Nitzan Shabek @shabeklab.bsky.social · 16/11/2024
our latest work @natureportfolio.bsky.social nature communications: Structural insights into strigolactone catabolism by carboxylesterases reveal a conserved conformational regulation rdcu.be/d0s6l
rdcu.be
Structural insights into strigolactone catabolism by carboxylesterases reveal a conserved conformational regulation
Nature Communications - Plant hormone levels are regulated by synthesis and breakdown, but the mechanism of strigolactone degradation remains unclear. This study reveals the structure of distinct...
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Reposted by Nitzan Shabek
Jens Hör @jenshoer.bsky.social · 11/11/2024
Should've done this a long time ago, but here's my first post on #Bluesky. Check out my postdoc paper on a bacterial ubiquitin-like defense system that we recently published! www.nature.com/articles/s41...
nature.com
Bacteria conjugate ubiquitin-like proteins to interfere with phage assembly - Nature
To mitigate&nbsp;phage infection, an antiphage defence system in bacteria conjugates a ubiquitin-like protein to a structural&nbsp;protein of&nbsp;the phage, demonstrating that conjugation of ubiquiti...
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Reposted by Nitzan Shabek
Rune Busk Damgaard @rbdamgaard.bsky.social · 15/11/2024
Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn
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Reposted by Nitzan Shabek
Denneal Jamison-McClung @dsjamison.bsky.social · 14/11/2024
I direct the UC Davis Biotechnology Program - looking forward to building #academicsky community! 🧬🧫🔬🧪🥼#ucdavis #biotech
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Nitzan Shabek @shabeklab.bsky.social · 16/11/2024
our latest work @natureportfolio.bsky.social nature communications: Structural insights into strigolactone catabolism by carboxylesterases reveal a conserved conformational regulation rdcu.be/d0s6l
rdcu.be
Structural insights into strigolactone catabolism by carboxylesterases reveal a conserved conformational regulation
Nature Communications - Plant hormone levels are regulated by synthesis and breakdown, but the mechanism of strigolactone degradation remains unclear. This study reveals the structure of distinct...
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Nitzan Shabek @shabeklab.bsky.social · 16/11/2024
molecular basis of SCOOP perception by the MIK2–BAK1 immune complex rdcu.be/d0s5E
rdcu.be
Mechanistic study of SCOOPs recognition by MIK2–BAK1 complex reveals the role of N-glycans in plant ligand–receptor–coreceptor complex formation
Nature Plants - Wu et al. elucidate the molecular basis for SCOOPs perception by the MIK2–BAK1 immune complex and demonstrate an unexpectedly pivotal role of N-glycans in plant...
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