Welcome to the McAlpine lab! Welcome to the McAlpine lab! The heart and brain are vital co-dependent organs and communication between them is essential to health. We study the immune and neural connec...

Nature Reviews Cardiology, Published online: 22 June 2026; doi:10.1038/s41569-026-01318-3A study in Nature reports that in mice, healthy lifestyle behaviours, including exercise and uninterrupted sleep, can limit clone expansion in clonal haematopoiesis and promote the phenotypic reprogramming of clonal haematopoiesis mutant cells, thereby reducing the risk of atherosclerosis.

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Sleep and exercise can slow clonal haematopoiesis and limit mutant cell-driven atherosclerosis.

Sleep and exercise can slow clonal haematopoiesis and limit mutant cell-driven atherosclerosis.

Ventricular tachycardia disrupts the heart’s coordinated pump function, leading to sudden cardiac death. Neutrophils, which are recruited in high numbers to the ischemic myocardium, promote these arrh...

Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

McGavern and colleagues identified a CD8+ T cell population that expresses GZMK in ʽtau-richʼ brains, where it may play a protective role against neurodegeneration.

The 2025 Gordon Research Conference on Atherosclerosis will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.

Cold-sensitive engrams contribute to learned thermoregulation in mice that are returned to an environment in which they previously experienced a cold challenge, through a network formed betw...

Myeloid cells contribute to the etiology of multiple sclerosis (MS), but the dynamics of myelopoiesis during disease progression is still unclear. Here the authors show, in both mouse models and clini...

Multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis.

This cohort study assesses whether sleep duration and quality are associated with incidence of type 2 diabetes among women with a history of gestational diabetes who participated in the Nurses’ Health...

Abstract. The relationship between sleep deprivation, obesity, and systemic inflammation is a critical area of investigation due to its significant impact

The posterolateral cortical amygdala and other connected brain regions have a key role in mediating the transition from investigative to aggressive behaviour in male mice.

Studies in humans and mice show that myocardial infarction recruits monocytes to the brain’s thalamus, promoting sleep, which in turn restricts cardiac inflammation and sympathetic sign...

Scientists found that after heart injury, immune cells called monocytes travel to the brain and trigger a deep sleep that promotes recovery in both mice and people.

Studies in humans and mice show that myocardial infarction recruits monocytes to the brain’s thalamus, promoting sleep, which in turn restricts cardiac inflammation and sympathetic sign...

Studies in humans and mice show that myocardial infarction recruits monocytes to the brain’s thalamus, promoting sleep, which in turn restricts cardiac inflammation and sympathetic sign...

Studies in humans and mice show that myocardial infarction recruits monocytes to the brain’s thalamus, promoting sleep, which in turn restricts cardiac inflammation and sympathetic sign...