iiinova — where your digital self keeps evolving

Matteo Cagiada @mcagiada.bsky.social · 13/11/2025

Hi Pierre! Thank you for your message! I have put this in my TO DO list for a revised version of the datasets (probably around review time). We had pretty compressed archives to fit zenodo limits, so I would check if zip compression can do it. I will update you when is live!

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Matteo Cagiada @mcagiada.bsky.social · 12/11/2025

FlAbDab and FTCRDab are open-access datasets designed for reuse, extension and community benchmarking. We’d love to hear from you if you build on them.

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Matteo Cagiada @mcagiada.bsky.social · 12/11/2025

Built on our customised CALVADOS 3 setup, they comprise CG simulations of >150,000 antibody and T-cell receptor systems, and reproduce ensemble metrics from all-atom and experimental data.

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Matteo Cagiada @mcagiada.bsky.social · 12/11/2025

My first full contribution from my time in @opig.stats.ox.ac.uk is now out! Together with @fspoendlin.bsky.social (and with contributions from King Ifashe), we created FlAbDab and FTCRDab: two large-scale, open molecular dynamics datasets to study flexibility in immune receptors.

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Stephanie Wankowicz @stephanieaw.bsky.social · 16/05/2025

The third episode of The Tortured Proteins Department is out now! We chatted about grant cancellations, exciting regional meetings and reunions, two fun new preprints, community norms around code release, and the importance of giving kudos. @fraserlab.com

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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 15/05/2025

Led by @vvouts.bsky.social in @rhp-lab.bsky.social, we measured the degron potency of >200,000 30-residue tiles from >5,000 cytosolic human proteins and trained an ML model for degrons 📜 www.biorxiv.org/content/10.1... 🖥️ github.com/KULL-Centre/...

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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 04/05/2025

While this paper looks interesting, let me just say (again) that (essentially all) NMR ensembles in the PDB are NOT thermodynamic ensembles or meant to represent these. They are "uncertainty ensembles" and using them to benchmark machine learning (or other) models of dynamics is not a good idea.

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Nele Quast @nele-q.bsky.social · 01/05/2025

Do you wish working with T-cell receptor structures was easier? Us too! STCRpy, our software suite for T cell receptor structure parsing, interaction profiling and machine learning dataset preparation is now available! Github: github.com/npqst/stcrpy/ Pre-print: www.biorxiv.org/content/10.1... 1/3

github.com

GitHub - npqst/STCRpy

Contribute to npqst/STCRpy development by creating an account on GitHub.

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Fergus Imrie @fergusimrie.bsky.social · 23/04/2025

3-year postdoc opportunity as part of the Novo Nordisk - Oxford Fellowship programme! Develop machine learning approaches for drug discovery with me, Charlotte Deane (Oxford), and Christos Nicolaou (Novo Nordisk). 1 week left to apply! Details in next post

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Matteo Cagiada @mcagiada.bsky.social · 18/04/2025

A huge thanks to @sokrypton.org for key contributions, and to Charlotte Deane (@opig.stats.ox.ac.uk) and @lindorfflarsen.bsky.social for their invaluable guidance and support.

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Matteo Cagiada @mcagiada.bsky.social · 18/04/2025

Backbone predictions are great - but what about side chains? Me and @emilthomasen.bsky.social are happy to present AF2χ, a tool for predicting side-chain heterogeneity in protein structures!. If you want to read more about it, check out our preprint and localColabFold implementation!

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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 17/04/2025

AlphaFold is amazing but gives you static structures 🧊 In a fantastic teamwork, @mcagiada.bsky.social and @emilthomasen.bsky.social developed AF2χ to generate conformational ensembles representing side-chain dynamics using AF2 💃 Code: github.com/KULL-Centre/... Colab: github.com/matteo-cagia...

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Brotman Baty Institute @brotmanbaty.bsky.social · 27/03/2025

Mark your calendars now. The next variant effects seminar is Monday, 1 April, 9 am (Pacific), featuring Joyce Kang @harvard.edu @broadinstitute.org & Yiyun Rao @pennstateuniv.bsky.social. @varianteffect.bsky.social Learn more: www.varianteffect.org/seminar-series

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Matteo Cagiada @mcagiada.bsky.social · 27/03/2025

If you want to hear more about this project, you can join me on June 26 at the next 39th Annual Symposium of The Protein Society (San Francisco), where I will present the results of this work!

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Matteo Cagiada @mcagiada.bsky.social · 27/03/2025

Many thanks to @sokrypton.org and @lindorfflarsen.bsky.social for their help and mentorship during this project!.

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Matteo Cagiada @mcagiada.bsky.social · 27/03/2025

Delighted to announce that our paper "Predicting absolute protein folding stability using generative models"(lnkd.in/dZJMiY4r) has been awarded the Protein Science BEST PAPER 2024 by @proteinsociety.bsky.social.

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Matteo Cagiada @mcagiada.bsky.social · 24/01/2025

I am happy to share our latest review, which discusses the challenges of predicting unbound antibody structures using deep learning. Special thanks to Alexander Greenshields-Watson for leading and coordinating this work! 🧬💻 doi.org/10.1016/j.sb... #AntibodyEngineering #DeepLearning

doi.org

Redirecting

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Oxford Protein Informatics Group (OPIG) @opig.stats.ox.ac.uk · 15/01/2025

OPIG is now on Bluesky! Follow us for updates about the group's latest work, web app updates, and more. opig.stats.ox.ac.uk

opig.stats.ox.ac.uk

OPIG

Oxford Protein Informatics Group

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Matteo Cagiada @mcagiada.bsky.social · 17/12/2024

As Kresten mentioned, the only way to install specific pytorch dependencies at the moment is to restart the kernel after installing a new version on Miniconda. I will add a warning at the top, so the next user will know! Thanks for the tip @msuskiewicz.bsky.social !

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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 14/12/2024

Predicting absolute protein folding stability using generative models @mcagiada.bsky.social @sokrypton.org & I used ESM-IF to predict ∆G for folding & conformational change Paper, code and colab 📜 dx.doi.org/10.1002/pro.... 💾 github.com/KULL-Centre/... 👩‍💻 colab.research.google.com/github/KULL-...

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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 16/03/2024

New preprint with @mcagiada.bsky.social & @sokrypton.org in which we present a benchmark and predictions of absolute protein stability (ΔG not ΔΔG) using using likelihoods from a generative model, and also benchmark it for conformational free energies against NMR 🧬 🧶 doi.org/10.1101/2024...

Scatter plot with experimental and predicted stabilities

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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 24/10/2023

I'm excited to present Francesco Pesce's work on developing, applying & experimental testing of a method to design intrinsically disordered proteins. Our algorithm combines MC sampling in sequence space with an efficient CG simulation model and alchemical free-energy calculations. 🍝 🧶🧬

Schematic outline of a design algorithm for intrinsically disordered proteins

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