A unified in-browser workflow from CAD to URDF kinematics

Understanding your tools and algorithms is what gives you agency in a digital world. Paris, November 25–26, 2026.

Phylopic, NIH Bioart, Bioicons, Scidraw, Open Science Art, Health Icons, Servier Medical Art, Biodiversity Heritage Library, the Noun Project, Segment Anything, Excalidraw, draw.io, Biographics

Protein-carbohydrate interactions play a key role in numerous biological processes, including immune response, and glycan-based ligands that can target specific protein receptors on a cell surface represent promising candidates for therapeutics applications. For example, in retinoblastoma, the DC-SIGN mannose receptor is overexpressed on the surface of pathogenic cells and represents an interesting target for mannose-based ligands. At the same time, these ligands should not bind to the MRC1 receptor, which is expressed by adjacent, healthy, retinal pigment epithelial cells and presents a carbohydrate recognition domain (CRD) similar to the one of DC-SIGN. Therefore, the challenge remains to obtain a detailed picture of the recognition process between carbohydrates and proteins, in order to design effective and selective therapeutic compounds. In this work we used classical, all-atom molecular dynamics (MD) simulations to investigate the interaction between several mannose based ligands and the CRDs from DC-SIGN and MRC1. The analysis of the protein-carbohydrate contacts from the resulting trajectories highlights the variability of the mannose binding modes on both CRDs, and shows how the increased affinity of mannose for the MRC1 CRD can be related to a specific mannose binding state that is not accessible in the DC-SIGN CRD.

The abstract: This PEP sets out to help make the discovery of a project’s virtual environment easier for tools by providing a default location as well as a way for a project to point to its preferre...

Submit your talk proposal for Compute! Paris 2026. The Call for Proposals is open from April 15th to May 24th, 2026.

English Edition:  Arnaud Legrand, Christophe Pouzat and Konrad Hinsen, three French researchers, who went through the pain of making research data and software reproducible. Out of that pain...

As the generation of data in the life and health sciences expands rapidly, there is a growing need for professionals and students in these fields to master core bioinformatics skills, particularly tho...

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Famille: Recherche et Enseignement Type de contrat : CDD lié à convention Catégorie: A Lieu de travail : Champs-sur-Marne Réf. 20260313-1590

Reimagining how you share, collaborate, and run Jupyter notebooks — all in your browser.