In this Review, Li and Durbin discuss how to generate telomere-to-telomere assemblies for large haploid or diploid genomes using currently available data types and algorithms, and outline remaining ch...

Protein sequences are constrained not only by the need to fold into stable structures, but also by specific functional requirements imposed by natural selection. Yet predictions of how amino-acid chan...

This study introduces iChIP2, a low-input chromatin immunoprecipitation followed by sequencing method that profiles histone post-translational modifications (hPTMs) simultaneously across diverse eukar...

Transmissible tumors have been reported in a handful of animal species, but never before among fish. Is it possible in humans?

A leukemia-like cancer is killing soft-shell clams along the east coast of North America. The cancer is transmitted between animals in the ocean, and appear ...

A strange, contagious cancer is threatening Tasmanian devils, but researchers’ fight is fueling breakthroughs in science, survival, and hope.

The story of CTVT—a contagious cancer that spreads from dog to dog—gets weirder all the time.

Whole-genome sequencing analysis of tumour and matched non-tumour host tissues of the brown bullhead catfish reveals a type of naturally occurring transmissible cancer.

Plants can move rapidly without muscles, as seen in the Venus flytrap’s snapping lobes—a long-standing puzzle in plant biomechanics. Trap closure involves an elastic instability, but the active mechan...

The future position holder will lead an internationally recognized research program that combines excellent basic research with clear perspectives for

This work introduces the Runs N’ Poses dataset for benchmarking deep learning methods on the protein–ligand complex prediction task. It shows that current methods rely on memorization, challenging the...

Because all known living organisms are made from at least 20 canonical amino acids, the feasibility of life using a more simplified alphabet remains unclear. In this work, we leveraged computational d...

Air-Borne: The Hidden History of the Life We Breathe   Order Now The fascinating, untold story of the air we breathe, the hidden life it...

Airborne genetic material can be used to paint a picture of ecosystem health, watch for invasive species and even identify humans.

Extraer ADN del aire permite detectar patógenos y monitorizar la biodiversidad. Sin embargo,esto puede convertirse en una herramienta de control y los expertos llaman a la regulación del sector.

Twenty-five years after the sequencing of the human genome, scientists are still uncovering hidden layers of the “book of life”. A team led by CRAG researcher José Luis Riechmann published the first characterization of peptides derived from sORFs during flower development in Arabidopsis thaliana 🌸🔬

Scientists have long debated the origins of exceptional human achievements. This literature review summarizes recent evidence from multiple domains on the acquisition of world-class performance. We re...

G-protein coupled receptors (GPCRs) are the most abundant class of human receptors and drug targets. The vast majority of GPCR drugs bind the conserved orthosteric pocket, which can lead to non-specif...

Many proteins function as switches, detecting chemicals and transducing their concentrations into cellular responses. Receptor switches are key to the integration of environmental signals, yet it is n...