iiinova — where your digital self keeps evolving

Reposted by Martin Borch Jensen

Jay Roshe @jayroshe.bsky.social · 04/01/2026

Essay by @martinbjensen.bsky.social on limitations of current aging clocks on metrics (accuracy, responsiveness, interpretability, stability, applicability, cost) in various intended uses (R&D, consumer health, clinical trials, FDA approval, medical care). norngroup.substack.com/p/do-we-have...

norngroup.substack.com

Do we have a useful aging clock?

13 years after the first 'aging clock' was published we're still measuring mouse lifespan and unable to run human aging trials. What's missing?

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Andrew Payne @andrewcpayne.bsky.social · 01/10/2025

E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. Read more: e11.bio/blog/prism

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Mark A. Hanson @hansonmark.bsky.social · 10/07/2025

The "reproducibility crisis" in science constantly makes headlines. Repro efforts are often limited. What if you could assess reproducibility of an entire field? That's what @brunolemaitre.bsky.social et al. have done. Fly immunity is highly replicable & offers lessons for #metascience A 🧵 1/n

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Martin Borch Jensen @martinbjensen.bsky.social · 04/07/2025

Like the DNA of an organism, the Constitution assembled around itself a vast substrate, of people chasing dreams and stumbling on the way, of physical transformation, of thoughts that bend history. As complex life arises from simple nutrients, so does a land of opportunity arise from simple ideas.

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Dr. Nahid Bhadelia @bhadeliamd.bsky.social · 30/05/2025

In 1 month, BEACON has already reported 181 disease events & 381 individual reports. We're excited to announce that starting June 2nd, BEACON will be sending a free Weekly Disease Event Digest on Mondays to help you stay informed about emerging threats globally. Sign up below!

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Sky Marchini @sky.skymarchini.net · 26/05/2025

people get mad at me when I say this but it's a Serious Problem for bluesky's long-term viability that the userbase actively tries to bully people they don't like off here

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Ethan Mollick @emollick.bsky.social · 26/05/2025

Hopefully things change here, as my big worry about AI talk on this site is that people are being misled about the capabilities of AI by influencers who are telling them what they want to hear. AI is not going away, it will impact all of our futures, and it needs more voices shaping its direction.

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Ethan Mollick @emollick.bsky.social · 26/05/2025

After consideration, I will post occasionally, but heavily censor what I share compared to other sites. I tried making the transition, but talking about AI here is just really fraught in ways that are tough to mitigate & make it hard to have good discussions (the point of social!). Maybe it changes

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Boo!-per Lund @cooperlund.online · 26/05/2025

The problem is that Bluesky is still a niche platform at 1.3 Mil active users per day globally. Getting your boss to say yes to making an account and dedicating the time and effort to maintaining it means they need to see positives for that investment. A middle finger isn’t a good return.

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Gordian Biotechnology @gordianbio.bsky.social · 16/05/2025

This news should instill urgency and remind us to ask ‘why not sooner?’. @martinbjensen.bsky.social shared a long-term vision for how cures could become abundant, if we believe fast, systematic cure discovery is possible, and build the tools to make it happen. www.gordian.bio/blog/cures-o...

gordian.bio

Cures On Demand - Gordian Biotechnology

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Michal Caspi Tal, PhD @immunofever.bsky.social · 11/05/2025

1/ A long standing paradox in my mind (from always seeing immune "strength" or reactivity drawn as a spectrum from immunodeficiency to autoimmunity) was resolved this year at #AAI #Immunology2025. WHY do SO many people have both simultaneously? Each infection brings risk of developing autoimmunity!!

Figure 4 from "How persistent infection overcomes peripheral tolerance
mechanisms to cause T cell-mediated autoimmune disease" by Arup Chakraborty

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Martin Borch Jensen @martinbjensen.bsky.social · 30/04/2025

"Understanding an idea meant entangling it so thoroughly with all the other symbols in your mind that it changed the way you thought about everything." @gregegansf.bsky.social

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Reposted by Martin Borch Jensen

Robert Califf @robcaliff.bsky.social · 23/04/2025

I've started blogging on substack to provide a bit more depth. Rationale is provided in the first blog. I'm using some great artwork, but I've lost the source, so the great person who created FDA as Humpty Dumpty--please identify yourself! substack.com/home/post/p-...

substack.com

Why Blog?

We are living in extraordinary times.

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Martin Borch Jensen @martinbjensen.bsky.social · 20/04/2025

@hanascientist.bsky.social and I wrote up some thoughts grappling with rising animosity and mistrust of scientists and their institutions. Would love feedback and responses. www.liebertpub.com/doi/full/10....

liebertpub.com

How Did Scientists Become the Enemy? | GEN Biotechnology

GEN Biotechnology

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Reposted by Martin Borch Jensen

The New York Times @nytimes.com · 11/04/2025

Kseniia Petrova, a Harvard scientist who fled Russia after protesting its invasion of Ukraine, has been captive to the hard-line immigration policies of the Trump administration for nearly eight weeks. She fears arrest if she is deported.

nytimes.com

She Worked in a Harvard Lab to Reverse Aging, Until ICE Jailed Her

President Trump’s immigration crackdown ensnared Kseniia Petrova, a scientist who fled Russia after protesting its invasion of Ukraine. She fears arrest if she is deported there.

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Martin Borch Jensen @martinbjensen.bsky.social · 09/04/2025

Appreciate everyone pushing science forward in these days. Marton Meszaros wrote a great primer on what an #aging #biomarker needs to look like, and more importantly what the prerequisite datasets are. Punchline: We may need to build them out, and should start now. norn.group/writing/data...

norn.group

Data Gaps that Bottleneck Aging Biomarker Discovery — Norn Group

What’s holding back aging biomarkers? Despite growing excitement, most aging biomarkers today remain clinically irrelevant. This piece dives into the real bottleneck: our data. It maps the missing da...

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Reposted by Martin Borch Jensen

Julia Bauman @juliabauman.bsky.social · 06/04/2025

Any scientists want to help with a science communication project? Will reach thousands on TikTok! Details⬇️

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Marisa Kabas @marisakabas.bsky.social · 01/04/2025

I've created a shareable document with a list of the HHS offices gutted today that I'll be updating as often as possible. Have something to add? Message marisakabas.04 on Signal or email MKwrites4000@proton.me docs.google.com/document/d/1...

docs.google.com

HHS RIF running list

National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP) • Division of Reproductive Health • Division of pop health • Behavioral and clinical surveillance branch • Epidemiology ...

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Martin Borch Jensen @martinbjensen.bsky.social · 03/04/2025

Is it time to start splitting this governance experiment into a test and a control group? I mean, we have 50 states to work with, let's do some real economics and social science here.

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Ryan Moulton @moultano.bsky.social · 02/04/2025

What are some mappings from deleterious cravings to the real need that satisfies the craving? e. g. When you feel like eating candy, what you actually want is fruit. When you feel like playing videogames, what you actually want is progress and accomplishment. Etc.

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Cory Booker @corybooker.com · 02/04/2025

I may be tired and a little hoarse, but as I said again and again on the Senate floor, this is a moment where we cannot afford to be silent, when we must speak up.

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Reposted by Martin Borch Jensen

Kumar Garg @kumargarg.bsky.social · 31/03/2025

UPDATE: So excited to announce our newest program. Using a 15-week cohort model, goal is help more scientists design the type of ambitious research programs that were critical to advancements such as the Internet or mRNA vaccines. We plan to do multiple cohorts this year (info below).

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Martin Borch Jensen @martinbjensen.bsky.social · 29/03/2025

Sad, Marks was very forward thinking and should have been part of any effort to make FDA more effective.

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Martin Borch Jensen @martinbjensen.bsky.social · 28/03/2025

San Francisco license plates South San Francisco license plates

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Reposted by Martin Borch Jensen

Kaia Mattioli @kaiamattioli.bsky.social · 26/03/2025

our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell! key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity many are "negative regulators" & misexpressed in cancer www.sciencedirect.com/science/arti...

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Reposted by Martin Borch Jensen

John Doench @johndoench.bsky.social · 25/03/2025

Obvi we’re all in this together with this admin, but industry is not selling one’s soul, not even close. They’re our friends and colleagues and move the ball forward to getting science to impact peoples’ lives.

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Gordian Biotechnology @gordianbio.bsky.social · 25/03/2025

Check out chief science officer @martinbjensen.bsky.social’s post tackling misconceptions about AAV gene therapy only being best suited for rare diseases, and how factors like cost would be very different for common diseases like Parkinson’s, heart failure, and arthritis.

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Grace Lindsay @neurograce.bsky.social · 23/03/2025

I'm organizing a "Data for Good Rapid Response Team", i.e. a set of people who can be mobilized to work on short data science projects to help various groups and organizations. Sign up here if this is of interest to you, and please share with others with data science skills.

docs.google.com

Data-for-good rapid response team

I'm collecting people with data science skills who may want to hear about sporadic opportunities to use their skills for good on short projects. Project themes will center on topics I am connected wit...

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Reposted by Martin Borch Jensen

Michal Caspi Tal, PhD @immunofever.bsky.social · 22/03/2025

We're planning an incredible launch event for our new Menstruation Science initiative --- exploring the complexities of the far-reaching effects of sex hormones on human physiology in sickness and in health. I hope you can join us in-person or online! cgr.mit.edu/2025/03/17/s...

cgr.mit.edu

MIT Menstruation Science Launch Event – April 9, 2025 • The MIT Center for Gynepathology Research

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Travis @coloradotravis.bsky.social · 22/03/2025

Indeed, and this is explored at length with a number of examples in Robert Cialdini’s book “Influence” where he discusses how this is part of the process of re-wiring people into regime collaborators.

“An examination of the Chinese prison-camp program shows that its personnel relied heavily on commitment and consistency pressures to gain the desired compliance from prisoners. Of course, the first problem facing the Chinese was how to get any collaboration at all from the Americans. These were men who were trained to provide nothing but name, rank, and serial number. Short of physical brutalization, how could the captors hope to get such men to give military information, turn in fellow prisoners, or publicly denounce their country? The Chinese answer was elementary: Start small and build. For instance, prisoners were frequently asked to make statements so mildly anti-American or pro-Communist as to seem inconsequential (“ The United States is not perfect.””

““In a Communist country, unemployment is not a problem.”). But once these minor requests were complied with, the men found themselves pushed to submit to related yet more substantive requests. A man who had just agreed with his Chinese interrogator that the United States is not perfect might then be asked to indicate some of the ways in which he thought this was the case. Once he had so explained himself, he might be asked to make a list of these “problems with America” and to sign his name to it. Later he might be asked to read his list in a discussion group with other prisoners. “After all, it’s what you really believe, isn’t it?” Still later he might be asked to write an essay expanding on his list and discussing these problems in greater detail. The Chinese might then use his name and his essay in an anti-American radio broadcast beamed not only to the entire camp, but to other POW camps in North Korea, as well as to American forces in South Korea. Suddenly he would find himself a “collaborator,” having given aid to the enemy. Aware that he had written the essay without any strong threats or coercion, many times a man would change his image of himself to be consistent with the deed and with the new “collaborator” label,”

often resulting in even more extensive acts of collaboration. Thus, while “only a few men were able to avoid collaboration altogether,” according to Dr. Schein, “the majority collaborated at one time or another by doing things which seemed to them trivial but which the Chinese were able to turn to their own advantage. . . . This was particularly effective in eliciting confessions, self-criticism, and information during interrogation.””

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Reposted by Martin Borch Jensen

𝙲𝚑𝚊𝚛𝚕𝚎𝚜 𝙲. 𝙼𝚊𝚗𝚗 @charlescmann.bsky.social · 22/03/2025

Happy to report the second bit of my series, "How the System Works," is now out for subscribers. Paywall will be lifted a bit soon (stay tuned!). (www.thenewatlantis.com/publications...) Meanwhile, if you're curious, here's the intro: www.thenewatlantis.com/publications...

thenewatlantis.com

We Live Like Royalty and Don’t Know It

Introducing “How the System Works,” a series on the hidden mechanisms that support modern life

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Adam Marblestone @adammarblestone.bsky.social · 21/03/2025

There are so many inspiring examples of scientific roadmaps out there: this post was our quick way of introducing new explorers of the scientific landscape to this fascinating genre. Expect more from us in terms of releasing roadmaps & thinking soon and let us know which of your favorites we missed!

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Martin Borch Jensen @martinbjensen.bsky.social · 21/03/2025

"Freedoms are not only the primary ends of development, they are also among its principal means." Amartya Sen

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Martin Borch Jensen @martinbjensen.bsky.social · 20/03/2025

AAV gene therapy is usually associated with rare genetic disease, but trials are ongoing in chronic diseases like arthritis and Parkinson's. We wrote on the feasibility of gene therapies for common disease and how current assumptions about e.g. costs would need to change. norn.group/writing/gene...

norn.group

Gene Therapy for Common Diseases — Norn Group

AAV gene therapy costs are rapidly dropping, echoing antibody manufacturing’s 15–20-year trajectory. Discover how scaled production, better safety data, and innovative delivery strategies open the door to treating common diseases like Parkinson’s, arthritis, and more.

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Martin Borch Jensen @martinbjensen.bsky.social · 20/03/2025

@norngroup.bsky.social is excited to sponsor the continued great work of Harvard Aging Initiative!

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Jason Crawford @jasoncrawford.org · 18/03/2025

The 150-year history of d/acc, a $120M progress fund, fertility on demand, 19th-century kids' sci-fi, the real lesson of Cassandra’s curse, giving the Devil the benefit of law, and more: newsletter.rootsofprogress.org/p/links-and-...

newsletter.rootsofprogress.org

Links and short notes, 2025-03-18

The 150-year history of d/acc, a $120M progress fund, fertility on demand, 19th-century kids' sci-fi, the real lesson of Cassandra’s curse, giving the Devil the benefit of law, and more

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KLAB - finding a cure for GI dysmotility at #HarvardStrong @klab.bsky.social · 16/03/2025

It pains us to say this. Our lab aims to find cures for many GI conditions. We proudly do both discovery & mentor students - Americans & non-americans alike, & we will have to pause both..unless we find support. So please, help support us keeping discovering & mentoring www.enteric-neuron.com/help

enteric-neuron.com

Help support our work! | home

help, support, philanthropy, science, education, gastrointestinal motility disorders, enteric neurobiology, enteric neurons

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Dave Baltrus 🦦 @surtlab.bsky.social · 15/03/2025

In my 25 years since high school I’ve seen 1. HIV/AIDS go from death sentence to manageable with drugs 2. Cystic fibrosis go from pretty much an extended death sentence to manageable with drugs 3. Sickle cell go from a horrible disease to (almost maybe) cured by gene therapy Simply incredible

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Alexander Berger @albrgr.bsky.social · 11/03/2025

Scientific and technological progress drive long-run prosperity. Ben Jones & @larrysummers.bsky.social estimate that *new ideas* account for ~50% of US per-capita GDP growth, with social returns of $14 for each $1 invested in R&D. www.nber.org/papers/w27863

nber.org

A Calculation of the Social Returns to Innovation

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Caleb Lareau @caleblareau.bsky.social · 14/03/2025

Trying a slightly new model (for us at least) of #openscience. With @ronanchaligne.bsky.social and @karolisk.bsky.social, we pitted 10x Genomics Chromium GEM-X against Illumina PIPseq V head-to-head to understand these two platforms for single-cell genomics. Some thoughts off the bleeding edge: /1

media.tenor.com

a baby is eating a piece of food while sitting on the ground .

ALT: a baby is eating a piece of food while sitting on the ground .

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Alexandria Ocasio-Cortez @aoc.bsky.social · 14/03/2025

New Yorkers: Call Sen. Gillibrand’s office to vote NO on cloture and NO on the Republican Spending Bill. They vote in the morning. ☎️: (202) 224-4451

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Martin Borch Jensen @martinbjensen.bsky.social · 13/03/2025

A lot of the replies here are saying "if it cant get the aource right why should we trust". I'm not saying LLMs are right all the time, but this is very testable: ask for something you know well, see how correct and then look at sources. For me, most common is answers are right and sources made up.

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Ben Werdmuller @werd.io · 11/03/2025

In a world where we really need to shine a spotlight on abuses of trust in the public interest, my colleagues at @propublica.org are doing the work. Donations keep it free to read and help us make as big an impact as possible. If you have the means, please consider sending a donation of any amount:

give.propublica.org

ProPublica

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Nikhil Garg @nkgarg.bsky.social · 10/03/2025

*Please repost* @sjgreenwood.bsky.social and I just launched a new personalized feed (*please pin*) that we hope will become a "must use" for #academicsky. The feed shows posts about papers filtered by *your* follower network. It's become my default Bluesky experience bsky.app/profile/pape...

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Coleen Murphy @ctmurphy1.bsky.social · 10/03/2025

NJ folks, Booker's number is (202) 224-3224, or (973) 639-8700, or (856) 338-8922

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