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Adam Marblestone

@adammarblestone.bsky.social
1.8K followers 543 following 66 posts

Technologist, scientist. Co-founder of Convergent Research.

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Reposted by Adam Marblestone
Anand Muthusamy @anandmuthusamy.bsky.social · 08/09/2026
Hello world! We’re @melodyfro.bsky.social Most wearables don’t go far beyond heart rate and activity. Lab diagnostics paint a deeper picture but don’t read continuously. Melody is building biosensors, devices, and standards to bridge this gap. Hear our story at melodyfro.org
melodyfro.org
Melody – Common Sensing
Nonprofit using protein engineering to build devices that continuously sense and adjust human biochemistry. Based in Pasadena, CA.
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Adam Marblestone @adammarblestone.bsky.social · 19/08/2026
www.smithsonianmag.com/science-natu...
smithsonianmag.com
Earth's Organisms Developed Via Evolution. Some Theorists Wonder: What if the Entire Cosmos Did, Too?
The idea that universes evolve like organisms sat on the fringes of theoretical physics for decades. Then, a Substack post and a 2022 find by the James Webb Space Telescope boosted the concept
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Reposted by Adam Marblestone
Science Magazine @science.org · 18/08/2026
With a lens array in Chile, astronomers capture clumps of gas from a dying star returning to the Galaxy. Learn more: scim.ag/4g6qThX
New telescope reveals a missing link in the cosmic recycling of matter
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Reposted by Adam Marblestone
Daniel Clery @danclery.bsky.social · 12/08/2026
New telescope reveals a missing link in the cosmic recycling of matter | Science | AAAS 🔭🧪 @science.org www.science.org/content/arti...
science.org
New telescope reveals a missing link in the cosmic recycling of matter
With a lens array in Chile, astronomers capture clumps of gas from a dying star returning to the Galaxy
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Adam Marblestone @adammarblestone.bsky.social · 12/08/2026
Go Dragonfly FRO!
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Adam Marblestone @adammarblestone.bsky.social · 24/07/2026
OSTP's new report, "Science: A New Golden Age," reaches for extraordinary scientific progress and calls for focused research organizations, X-Labs, and metascience experiments inside federal agencies to help get there. That’s good news!
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Adam Marblestone @adammarblestone.bsky.social · 15/07/2026
fas.org/publication/...
fas.org
Scaling Team Science is the Important Experiment We Need - Federation of American Scientists
X-Labs seek to expand on what FROs have shown is possible: the generation of foundational infrastructure for entire new fields of research science.
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Reposted by Adam Marblestone
Dan Garisto @dangaristo.bsky.social · 10/07/2026
Previously, Science broke the news that NSF would be clawing back money, and attributed it to the 10-year, 1.5 billion X-Labs initiative. We have an official denial from NSF, and internal budget numbers for the X-Labs account suggest it will only spend $50 million this year, all from TIP's budget.
science.org
Exclusive: NSF slashes research programs to support new tech initiative, insiders say
Unexpected shift in funds has meant sharp drop in grants this fiscal year
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Reposted by Adam Marblestone
Nashville Post @nashvillepost.com · 14/07/2026
State adds to funding promises for National Science Foundation X-Labs research groups www.nashvillepost.com/tennessee-inv…
nashvillepost.com
Tennessee investing $3M into quantum teams
State adds to funding promises for National Science Foundation X-Labs research groups
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Reposted by Adam Marblestone
ASM @asm.org · 10/07/2026
ASM has submitted formal comments urging the White House Office of Management and Budget to withdraw a proposed rule that would weaken the peer review process, limit scientific collaboration and networking and create new barriers to conducting and disseminating research: asm.org/articles/pol...
asm.org
ASM Opposes OMB Grants Rule | ASM.org
ASM strongly opposes the Office of Management and Budget's proposed rule on federal financial assistance, citing risks to scientific integrity and innovation.
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Reposted by Adam Marblestone
Caleb Watney @calebwatney.bsky.social · 22/06/2026
We've been checking with contacts inside the NSF and they are saying this is wildly inaccurate. X-labs is not anywhere close to big enough to make up this hole. As far as I have heard, this program is coming out of TIP specific funding
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Reposted by Adam Marblestone
The Deliverome Project @deliverome.org · 27/05/2026
Today we're launching Deliverome Bio, a focused research organization tackling one of the biggest bottlenecks in medicine: getting therapeutics to tissues beyond the liver.
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Reposted by Adam Marblestone
Changyang Linghu @changyanglinghu.bsky.social · 22/05/2026
Introducing GLOBE—a new technology for brain-wide, single-cell recording of cellular activity in vivo. GLOBE can continuously record from nearly a quarter million individual neurons simultaneously across a mouse brain. Preprint out on bioRxiv: doi.org/10.64898/202... 🧵(1/6)
Recording scalability in vivo
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Adam Marblestone @adammarblestone.bsky.social · 20/05/2026
www.essentialtechnology.blog/p/nsf-just-d...
essentialtechnology.blog
NSF Just Did Something Important
And so can you: how to reach out to Convergent about X-Labs
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Reposted by Adam Marblestone
Advanced Research + Invention Agency (ARIA) @aria-research.bsky.social · 20/05/2026
Seeking teams to test whether AI-enabled formal methods can make high-assurance cyber defense practical, at scale, through building production-grade software components backed by machine-checked proofs and validated through coordinated red-team exercises. bit.ly/49Wif30
bit.ly
Funding | Safeguarded AI
Learn more about funding in ARIA's Safeguarded AI programme.
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Reposted by Adam Marblestone
Adam Marblestone @adammarblestone.bsky.social · 14/05/2026
www.nsf.gov/news/nsf-ann...
nsf.gov
NSF announces $1.5B NSF X-Labs initiative to pursue generational breakthrough science efforts
Today, the U.S. National Science Foundation announced $1.5 billion over the next decade toward the NSF X-Labs initiative to tackle pressing scientific challenges through novel and innovative...
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Adam Marblestone @adammarblestone.bsky.social · 14/05/2026
www.nsf.gov/news/nsf-ann...
nsf.gov
NSF announces $1.5B NSF X-Labs initiative to pursue generational breakthrough science efforts
Today, the U.S. National Science Foundation announced $1.5 billion over the next decade toward the NSF X-Labs initiative to tackle pressing scientific challenges through novel and innovative...
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Reposted by Adam Marblestone
Ann Kennedy @antihebbiann.bsky.social · 24/04/2026
Agreed re the cortical column Markram targeted, but I think connectomics could be hugely beneficial to study of areas like hypothalamus, where we have evolutionarily wired "artisanal" circuits implementing very specific rules for how different drives interact with each other :)
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Adam Marblestone @adammarblestone.bsky.social · 24/04/2026
zenodo.org/records/1969...
zenodo.org
How to obtain a complete human connectome at synaptic resolution within the next decade
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Reposted by Adam Marblestone
Advanced Research + Invention Agency (ARIA) @aria-research.bsky.social · 14/04/2026
Full proposals are now open for our Massively Scalable Neurotechnologies programme. Led by Jacques Carolan, we are investing £50m to develop a new class of neurotech – interfaces that reach the brain via the body’s natural pathways. Submit by 11 May: link.aria.org.uk/MSNx
link.aria.org.uk
Massively Scalable Neurotechnologies
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Reposted by Adam Marblestone
Aaron Milstein @neurosutras.bsky.social · 27/03/2026
Our latest publication grapples with how the brain could implement gradient descent by sending learning targets top-down, gating plasticity with dendritic inhibition, and updating synaptic weights with biologically observed learning rules like BTSP. www.cell.com/cell-reports...
cell.com
Cellular and subcellular specialization enables biology-constrained deep learning
Galloni et al. introduce “dendritic target propagation”: a Dale’s law-compliant learning algorithm for cortical microcircuits with soma- and dendrite-targeting inhibition and realistic connectivity co...
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Reposted by Adam Marblestone
Benjamin Judkewitz @benjulab.bsky.social · 05/03/2026
First whole-brain recording of social sound processing in a vertebrate. Surprises start in the hindbrain; thalamus gates conspecific calls; male and female brains diverge downstream. Work by @joerghenninger.bsky.social, @mh123.bsky.social sky.social and team. www.biorxiv.org/content/10.6...
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Reposted by Adam Marblestone
Asterisk Magazine @asteriskmag.blogsky.venki.dev · 16/02/2026
The Sweet Lesson of Neuroscience
asteriskmag.substack.com
The Sweet Lesson of Neuroscience
Scientists once hoped that studying the brain would teach us how to build AI. Now, one AI researcher may have something to teach us about the brain.
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Reposted by Adam Marblestone
Lean Focused Research Organization @lean-lang.org · 11/02/2026
Terence Tao on how math is changing, #formalverification as the enabler of scaled human-AI collaboration: "The reason why scaling and AI and broad participation actually is a net win is because we have formal verification." 📺 www.youtube.com/watch?v=SuTx... #leanlang #leanprover
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Convergent Research @convergentresearch.bsky.social · 18/02/2026
We've just added a new FRO to our website! In this Essential Technology piece, we share three three principles from CHI-FRO, an engineering-heavy partnership to build out tools for probabilistic programming: www.essentialtechnology.blog/p/the-evolut...
essentialtechnology.blog
The evolution of CHI-FRO
Three principles from an engineering-heavy partnership to build out tools for probabilistic programming
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Reposted by Adam Marblestone
Nikolai Slavov @slavov-n.bsky.social · 04/02/2026
A special opportunity for lovers of mass spectrometry proteomics to join a like-minded team at PTI. Join a collaborative initiative to enable direct protein analysis at unprecedented scale, in partnership with leading instrument developers, academics, and industry leaders. 1/2
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Henry Lee @citizenlee.bsky.social · 03/02/2026
So you sequenced a billion+ bases. That don’t impress me much. JERBOA is a toolkit to figure out what genes do at scale. We've used it to unlock 43 non-model microbes across 12 different phyla.
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Convergent Research @convergentresearch.bsky.social · 29/01/2026
Light-microscopy brain mapping was picked as one of 7 technologies to watch in 2026 by Nature! Hear from E11's CEO @andrewcpayne.bsky.social: www.nature.com/articles/d41...
nature.com
From quantum computing to mRNA therapeutics: seven technologies to watch in 2026
Nature’s round-up of innovations that are poised to make a splash in the year ahead.
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Reposted by Adam Marblestone
bioRxivpreprint @biorxivpreprint.bsky.social · 26/11/2025
Synaptic MEMOIR: mapping individual synapses of neurons with protein barcodes www.biorxiv.org/content/10.1101/202…
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Reposted by Adam Marblestone
Convergent Research @convergentresearch.bsky.social · 23/12/2025
It's been an incredibly exciting year in metascience at large, and for us at Convergent. Last week, the NSF announced their Tech Labs Initiative. www.essentialtechnology.blog/p/the-future...
essentialtechnology.blog
The Future of Focused Research Organizations:
Working with Convergent on the NSF Tech Labs Initiative
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Reposted by Adam Marblestone
Toby Ord @tobyord.bsky.social · 18/12/2025
Dim Red Dot Scientists have just released a photo featuring a dim red dot. It is the light of a single star exploding in a galaxy so far far away that that nothing we do could ever affect it — even in the very fullness of time. It lies beyond the Affectable Universe. Let me explain… 1/🧵
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Convergent Research @convergentresearch.bsky.social · 16/12/2025
Last Friday, the @NSF released an RFI for a new Tech Labs Initiative, to "build and scale next-gen independent research organizations to advance science."
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Wilfred Mijnhardt @wmijnhardt.bsky.social · 19/10/2022
A Vision of Metascience; How does the culture of science change and improve? We need metascience entrepreneurs, seeking to achieve a scalable improvement in the social processes of science pllqt.it/Qg2rOs
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Adam Marblestone @adammarblestone.bsky.social · 12/12/2025
fas.org/publication/...
fas.org
Universities should help shape the vision for new NSF Tech Labs
At a time when universities are already facing intense pressure to re-envision their role in the S&T ecosystem, we encourage NSF to ensure that the ambitious research acceleration remains compatible w...
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Reposted by Adam Marblestone
Federation of American Scientists @scientistsorg.bsky.social · 12/12/2025
To mark the occasion, FAS CEO Daniel Correa spoke with @sgrodriques.bsky.social and @adammarblestone.bsky.social about how best to run a Tech Lab/FRO-style org, what they've learned, and the role federal funding can play: fas.org/publication/...
fas.org
NSF Wants To Supercharge FROs. We Spoke With the Scientists Who Proposed Them.
We recently spoke with Adam Marblestone and Sam Rodriques, former FAS fellows who developed the idea for FROs and advocated for their use in a 2020 policy memo.
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Adam Marblestone @adammarblestone.bsky.social · 12/12/2025
www.wsj.com/opinion/scie...
wsj.com
Opinion | Science Funding Goes Beyond the Universities
A new NSF initiative will support teams of researchers, a departure from the traditional practice of giving grants to individual professors.
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Adam Marblestone @adammarblestone.bsky.social · 12/12/2025
fas.org/publication/...
fas.org
NSF Wants To Supercharge FROs. We Spoke With the Scientists Who Proposed Them.
We recently spoke with Adam Marblestone and Sam Rodriques, former FAS fellows who developed the idea for FROs and advocated for their use in a 2020 policy memo.
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Adam Marblestone @adammarblestone.bsky.social · 12/12/2025
If you've been interested in FROs, you'll want to see this from NSF: sam.gov/opp/7332ade9... "sustained... support to... independent organizational structures operating outside of existing academic, start-up, and industry constraints... a dedicated, full-time team... operational independence..."
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Reposted by Adam Marblestone
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 07/12/2025
A genetic platform for a biocementation bacterium www.biorxiv.org/content/10.64898/20…
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[C]Worthy @cworthy.org · 24/11/2025
[C]Worthy has secured multi-year support from ORCA and the Patrick J. McGovern Foundation to scale open, trusted science tools for ocean-based carbon removal. We can’t scale what we can’t measure—this funding accelerates our MRV models + datasets. Full announcement: www.cworthy.org/media/cworth...
cworthy.org
[C]Worthy Secures Multi-Year Support From ORCA and the Patrick J. McGovern Foundation to Scale Open-Source Marine Carbon-Removal Tools — [C]Worthy
New multi‑year awards affirm the need for infrastructure built through [C]Worthy’s approach of marrying open-source science and practical tools for industry use.
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Reposted by Adam Marblestone
Kevin Mitchell @wiringthebrain.bsky.social · 21/11/2025
A global screen for magnetically induced neuronal activity in the pigeon brain www.science.org/doi/10.1126/... - so cool! 🐦🧠
science.org
A global screen for magnetically induced neuronal activity in the pigeon brain
How animals detect the Earth’s magnetic field remains a mystery in sensory biology. Despite extensive behavioral evidence, the neural circuitry and molecular mechanisms responsible for magnetic sensin...
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Reposted by Adam Marblestone
Alex Crits-Christoph @acritschristoph.bsky.social · 22/11/2025
Have a look if you are interested in how the team at @cultivarium.bsky.social is finding electroporation protocols for new microbes: both screening lots of conditions on a custom built electroporator concurrently, and cyclical iteration using bayesian optimization www.biorxiv.org/content/10.1...
biorxiv.org
Active learning guides automated discovery of DNA delivery via electroporation for non-model microbes
Delivery of recombinant DNA is foundational for understanding and engineering a target organism. Electroporation can be applied to any cell type, yet identification of a working protocol for new organ...
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Convergent Research @convergentresearch.bsky.social · 18/11/2025
Announced today: @evebio.bsky.social's pharmome-mapping dataset - the largest public map of how compounds do or don’t touch druggable targets - is now live on DrugBank's knowledgebase and available programmatically + interactively on Hugging Face, @hf.co. Learn more: evebio.org/pharmome-dat...
evebio.org
Putting Pharmome Data in Researchers' Hands : EvE Bio
We've been busy at EvE Bio these last two years establishing the largest available pharmome mapping dataset. Now it’s making its way into the world to drive real discoveries.
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Reposted by Adam Marblestone
Drew Schreiner @schreinerdrew.bsky.social · 17/11/2025
Poster now til 12 pm, come check it out at V6! #SfN25
a poster titled a synaptic locus of song learning
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David A. Markowitz @davidamarkowitz.bsky.social · 17/11/2025
Is there an academic/industry divide in attitudes about using AI to support discovery? I noticed this post has 3.6k likes on X but only 6 likes on Bluesky. It deserves more attention here!
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Advanced Research + Invention Agency (ARIA) @aria-research.bsky.social · 17/11/2025
As AI collapses coordination costs, our new thesis - Scaling Trust - explores how scalable trust infrastructure could usher in a world of many AI agents, capable of mobilising, negotiating, and verifying on our behalf across digital + physical spaces ↓ link.aria.org.uk/ST-thesis-BS
link.aria.org.uk
Programme development | Trust Everything, Everywhere
We are in the process of building a multi-year R&D programme within this space. Our programmes are designed to advance complex, large-scale ideas that require coordinated investment and management acr...
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Reposted by Adam Marblestone
Grace Lindsay @neurograce.bsky.social · 17/11/2025
It is actually an incredibly frustrating time to be a theoretical neuroscientist right now imo, for this reason
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STCmicrobeblog @stcmicrobeblog.bsky.social · 12/11/2025
cool! tools to making it easier to work with 𝘐𝘥𝘦𝘰𝘯𝘦𝘭𝘭𝘢 𝘴𝘢𝘬𝘢𝘪𝘦𝘯𝘴𝘪𝘴 (now 𝘗𝘪𝘴𝘤𝘪𝘯𝘪𝘣𝘢𝘤𝘵𝘦𝘳 𝘴𝘢𝘬𝘢𝘪𝘦𝘯𝘴𝘪𝘴) for PET degradation #MicroSky
Ideonella sakaiensis 201-F6
source: doi 10.1126/science.aad6359
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Reposted by Adam Marblestone
Addgene @addgene.bsky.social · 12/11/2025
Cool work from our neighbors at @cultivarium.bsky.social using components from the POSSUM Toolkit! What will they (or you!) find next? Check out the toolkit here: www.addgene.org/kits/cultiva...
addgene.org
Addgene: Cultivarium POSSUM Toolkit
Use this plasmid kit to identify and generate plasmids for use in non-model microbes.
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Reposted by Adam Marblestone
Alex Crits-Christoph @acritschristoph.bsky.social · 12/11/2025
Very happy to share our recent work @cultivarium.bsky.social on genetic tools for Ideonella sakaiensis, a (Betaproteo-)bacterium that degrades PET plastic. We identified a plasmid vector for the strain and generated a large RB-TnSeq library, screening for genes impacting plastic degradation.
Figure 2. PET screen results and RB-TnSeq gene fitness results
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