Project Tailwind is Coefficient Giving's call for founders to launch ambitious AI safety initiatives.

Almost half a million children under the age of 5 die of malaria each year. What if replacing a single amino acid in disease-carrying mosquitoes could help save them? After battling with rudimentary tools for millennia, malaria fighters are now armed with a potentially revolutionary technology. If only the public could get on board.

Strep A—the bacterium behind strep throat and impetigo—kills hundreds of thousands of people a year, mostly young people in LMICs—yet Strep A vaccine R&D is chronically underfunded.

Coefficient Giving, one of the world’s largest effective-giving fun...

YIMBY has revealed its report on construction permit filing activity for the first quarter of 2026 across the five boroughs.

Today, Coefficient Giving is launching the Strep A Vaccine Fund, a multi-donor initiative to accelerate vaccine development against one of the world's most neglected infectious diseases relative to its scale. Strep A kills ~639,000 people a year. There is no vaccine. I think that can change 🧵

Epistemic conservatism no longer favours long timelines

After decades of scientific and regulatory delays, several Strep A vaccine candidates are entering clinical trials. Without further funding for phase 3 studies, however, many will be hamstrung.

We are excited to announce a new Request for Proposals (RFP) for effective career organizations, defined as initiatives devoted to providing mentorship, advice, and opportunities to help people pursue highly impactful careers. Through this RFP, we aim to identify and support additional efforts in the effective careers space and streamline the application process for potential […]

Nature - Journals that focus on specific research questions could help to bridge the science–policy gap, if they can attract researchers.

Researchers at the company are trying to understand their A.I. system’s mind—examining its neurons, running it through psychology experiments, and putting it on the therapy couch.

In this talk, Alexander Berger, CEO of Open Philanthropy, discusses a number of examples of how philanthropic funding can help accelerate progress, especiall...

Wilson Lin at Cursor has been doing some experiments to see how far you can push a large fleet of "autonomous" coding agents: This post describes what we've learned from …

Epistemic note: This is the beginning of a planned series of posts trying to think about what a highly multi-polar post-AGI world would look like and to what extent humanity or human values could survive in such a world depending on our degree of alignment success. This is all highly...