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Mark Baxter 🏳️‍🌈🧂

@markgbaxter.bsky.social
2.8K followers 276 following 2.2K posts

Neuroscientist (PhD) interested in brain mechanisms of learning and memory. NHP anesthesiologist. Associate stats gay. 🏳️‍⚧️ Trans rights are human rights. No LGB without the T. He/him. 🏳️‍🌈

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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 39m
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Adrian M. Owen, OBE, FRS @comadork.bsky.social · 4h
Have grand theories of consciousness earned their keep? Our opinion, published in @cp-neuron.bsky.social today. @action-brain.bsky.social @cifar authors.elsevier.com/a/1nupi3BtfH...
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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 55m
going to try this to get 10x genomics to leave me alone
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toilet bones @toiletbones.bsky.social · 11h
Found the email I sent when I got accidentally added to the faculty listserv of an orthopedic surgery clinic and nobody would remove me so I sent this email to all faculty/staff/med students and they removed me almost immediately
Hello Bone Colleagues, 
I have invented a new type of ankle and I'm very excited to show it to you. Early raccoon trials suggest a 60% increase in scurrying speed and dramatic increases in fine motor banditry. I know we are not supposed to create super raccoons, but I think you'll change your mind and professional ethics when you see how cute they are. I believe we are on the cusp of a new era in advanced human scurrying because if medical science has taught me anything, it's that improvements in raccoons correspond 1:1 to improvements in humans. 

--
[My name]
Chief Bone Inventor
Chair, Department of Foot and Leg Innovation
Lord Mayor, Musculoskeletal Medicine 
Hartford HealthCare,
The Bone & Joint Institute at Hartford Hospital.
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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 56m
Jesus I deleted a recurring meeting that has ended and google emailed like a thousand people
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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 2h
tag yourself
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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · 2h
I'm thrilled to see my concept on the cover of @cp-trendscognsci.bsky.social this month! It was a fun challenge to illustrate the overlapping brain networks underlying cognition and highlight the complexity that future cBCIs must navigate to restore mental function in real time 🧠
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Ben Saunders @bensaunders.bsky.social · 7h
Very excited to share our new preprint. We identify the basolateral amygdala dopamine system as an important interface between dynamic shifts in the environment and decisions to engage in vigorous drug use. Really challenging studies led brilliantly by Dr. Megan Brickner.
biorxiv.org
The basolateral amygdala dopamine system shapes dynamic drug seeking states
Drug-associated sensory cues and contexts exert powerful influence over drug seeking motivation, but in vivo brain mechanisms governing this process remain unclear. Here, we recorded and manipulated d...
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I-75 Scientist @flscitriguy.bsky.social · 19h
For those w/ Active, Pending or preparing K awards/applications: “The purpose of this notice is to update the implementation timeline from October 12, 2027, to effective immediately. Therefore, DMS Plans are no longer required for NIH Career Development (K) awards:” grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-26-120: Accelerated Implementation of Data Management and Sharing Plan Changes for NIH Career Development (K) Awards
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Accelerated Implementation of Data Management and Sharing Plan Changes for NIH Career Development (K) Awards NOT-OD-26-...
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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 21h
initially I thought "oh great mice have preconceptions now along with empathy and regret"
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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 05/10/2026
are... are these benefits in the room with us right now?
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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 05/10/2026
static.klipy.com
Jinkx Monsoon's Dramatic Gasp
ALT: Jinkx Monsoon's Dramatic Gasp
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MacRumors.com @macrumors.bsky.social · 05/10/2026
Mac Users Reclaim Storage With New Apple Intelligence Removal Tool
macrumors.com
Mac Users Reclaim Storage With New Apple Intelligence Removal Tool
A new open-source tool is making waves in the Mac community by helping users reclaim valuable storage space taken up by Apple's AI models. Called "RemoveMacAI," the tool disables Apple Intelligence on macOS 27, removes its downloaded models, and prevents them from being downloaded again. In macOS 27, Apple removed the toggle to disable Apple Intelligence wholesale, and simply disabling individual features doesn't remove the models from your Mac's drive. As explained by the developer, RemoveMacAI gets around this by using a configuration profile to switch off Apple's own asset management service and remove the models. It then configures the system so attempts to download the removed models are redirected to a closed local port, preventing them from immediately coming back. And it does all this without disabling System Integrity Protection (SIP) or manually deleting files from protected system locations, unlike some older tools have. The tool can reclaim roughly 10GB+ of space depending on which models are present on your Mac, though some users are reporting cases where Apple Intelligence models are taking up a lot more space. With the Apple models gone, you lose all Siri-related AI features, Writing Tools, Genmoji, Image Playground, ChatGPT integration, summaries, smart replies, inline predictions, Photos Clean Up, Spatial Photos, and Xcode predictive completion. Even so, plenty of users appear happy to make the sacrifice to free up space, especially on non-upgradeable Macs with 256GB of storage. The profile reportedly persists across updates. And if you're wondering, dictation still works. The project has attracted hundreds of GitHub stars since its release last week, and there's lots of discussion on Reddit and Hacker News about the need for such a tool. Just be aware that MacRumors isn't endorsing RemoveMacAI, and anyone using it does so at their own risk. The developer has mentioned one caveat, and it's that some of the configuration-profile restriction keys that the tool relies on were deprecated by Apple in macOS 26.4. While they still work in macOS 27.0.1, a future version could always change that. Something to keep in mind.Tag: Apple Intelligence This article, "Mac Users Reclaim Storage With New Apple Intelligence Removal Tool" first appeared on MacRumors.com Discuss this article in our forums
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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 05/10/2026
ugh. I'm going back to bed
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Alicia Izquierdo @aliciaizquierdo.bsky.social · 05/10/2026
Newly-accepted paper from Sara Burke's lab: A 🐀 touchscreen task is sensitive to perceptual difficulty and captures performance declines with greater feature overlap, but does not detect age-related memory deficits 🤔@touchscreencog.bsky.social academic.oup.com/oons/article...
academic.oup.com
An Operant-based Touchscreen Morph Discrimination Task Does Not Detect Age-related Mnemonic Similarity Deficits in Rats
Abstract. The Mnemonic Similarity Task (MST) is sensitive to age-related cognitive decline in humans and has been adapted for rodents using 3D objects, whe
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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 04/10/2026
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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 04/10/2026
pls fax
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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 03/10/2026
Immune response and mood is no fucking joke because I had my covid and flu shots yesterday and this morning I hate everything 🔪
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Dominique Baker @bakerdphd.bsky.social · 02/10/2026
Writing something where I will be liberally citing @lilymasonphd.bsky.social's latest and realizing that I can't cite every single thing I would like to because then I'm just reprinting her work. So, I've gotta thread about it instead. muse.jhu.edu/pub/1/articl...
Screenshot of the article website. Title is: Polarization Is Not the Problem. Author is Lilliana Mason. Journal is the Journal of Democracy, Volume 37, Number 4, October 2026. From Johns Hopkins University Press.
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Michael Hendricks 🇨🇦 @michaelhendricks.bsky.social · 02/10/2026
Some thoughts on the CIHR Project survey. I am very concerned about panicked “do something” changes in the face of declining success rates and rising app pressure. The same thing that lead to several years of stepping on rakes during the “Reforms.”
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Vinny Costa @vincentcostaphd.bsky.social · 02/10/2026
Cookie Monster is pure good. If AI make Cookie feel sad. AI must be evil.
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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 02/10/2026
I am SCREAMING
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Vinny Costa @vincentcostaphd.bsky.social · 02/10/2026
Please someone in Hollywood pay an actual human $ to write a script building off this story that ends with Matt going to jail and Cookie Monster securing the world record for largest baked chocolate chip cookie. It will surpass all box office records.
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Will Lowe @conjugateprior.org · 02/10/2026
Periodic reminder that what really identifies a Bayesian is their fondness for integrating out uncertainty, i.e. marginalization, not wedging things into Bayes theorem. Even Fisher did that from time to time.
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 02/10/2026
Translating functional brain activity between humans and monkeys www.biorxiv.org/content/10.64898/20…
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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 01/10/2026
oh no the opposite, I was thinking a driver of a driverless car is the reverse centaur to be blamed for the mistakes of software
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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 01/10/2026
www.theguardian.com/books/2026/j...
theguardian.com
The Reverse Centaur’s Guide to Life After AI by Cory Doctorow review – the real price of artificial intelligence
A vivid and entertaining polemnic on the economics of the tech revolution, filled with righteous ire
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Emily M. Bender @emilymbender.bsky.social · 01/10/2026
New from @timnitgebru.blacksky.app and me: "It is high time for us to regulate usage of systems sold as “AI”, not because they are magical machines, but because they are error-prone products that shouldn’t be used in high stakes scenarios." www.theguardian.com/commentisfre...
theguardian.com
Forget ‘superintelligence’: error-prone AI nearly sparked world war three this month | Timnit Gebru and Emily M Bender
The risks of AI aren’t what we think they are, as a recent security incident between China and the United States reveals
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Timnit Gebru @timnitgebru.blacksky.app · 01/10/2026
In this op-ed, @emilymbender.bsky.social & I remind everyone that it's the BELIEF that these products are "superintelligent," enough to rely on them for this type of use, that almost rendered humanity extinct.
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Timnit Gebru @timnitgebru.blacksky.app · 01/10/2026
I'm not sure if y'all saw a CNN report on how the US had almost started WW3 with China based on fabricated information generated by a chatbot, claiming that a Chinese vessel was carrying components of nuclear weapons. That was an "existential threat" to humanity www.theguardian.com/commentisfre...
theguardian.com
Forget ‘superintelligence’: error-prone AI nearly sparked world war three this month | Timnit Gebru and Emily M Bender
The risks of AI aren’t what we think they are, as a recent security incident between China and the United States reveals
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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 01/10/2026
Doubtful since that was my last year of undergrad.
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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 01/10/2026
I haven't used latex since 1993 😆
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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 01/10/2026
oh don't you start! MDs can't use latex
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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 30/09/2026
oh god I just accidentally dragged a figure out of place in a word document
static.klipy.com
Window Fuckit
ALT: Window Fuckit
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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 30/09/2026
static.klipy.com
Po the Panda's Surprised to Confident Reaction
ALT: Po the Panda's Surprised to Confident Reaction
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Melissa Herman @melissaherman.bsky.social · 30/09/2026
Check out our latest work from shining star (and amazing physiologist) postdoc @juliamitchell.bsky.social investigating the effects of alcohol and nicotine polysubstance use on prelimbic cortex activity and behavior 🧠🍸🚭 www.sciencedirect.com/science/arti...
sciencedirect.com
Alcohol and nicotine vapor co-exposure differentially engages prelimbic prefrontal cortex activity and decreases anxiety-like behavior in rats
Alcohol and nicotine are two leading causes of preventable deaths in the United States. Simultaneous co-use of alcohol and nicotine is rising, as is t…
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Brad Postle @bradpostle.bsky.social · 30/09/2026
Really chuffed about this one. It's impt for our efforts to understand neural and computational bases of controlling the contents of WM. It also highlights a control-related signal in the beta band that is NOT "inhibitory" in the way often assumed doi.org/10.1523/JNEU...
doi.org
Prioritization in Working Memory Reduces Interference via Beta Band-Linked Stimulus Transformations
We studied the effects of prioritization in a two-step retrocuing task in which male and female humans hold two items in working memory, and the item not cued by the first cue cannot be dropped becaus...
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Bita Moghaddam @bita137.bsky.social · 30/09/2026
And I was not just theorizing: the ideas are supported by several recent preclinical papers including this from the lab www.nature.com/articles/s41...
nature.com
Grin2a knockout in adolescent dopamine neurons disrupts prediction error signaling and produces a phenotype relevant to schizophrenia - Molecular Psychiatry
Molecular Psychiatry - Grin2a knockout in adolescent dopamine neurons disrupts prediction error signaling and produces a phenotype relevant to schizophrenia
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Bita Moghaddam @bita137.bsky.social · 30/09/2026
Please check out my futuristic opinion piece in @jamapsychiatry.com "specific treatments for schizophrenia that are tailored to target symptoms at different developmental stages are no longer the stuff of science fiction, but instead are realistic future goals" jamanetwork.com/journals/jam...
jamanetwork.com
Updating Treatment Goals for Schizophrenia
This article discusses research providing renewed reasons to revisit the utility of glutamatergic drugs for treating schizophrenia.
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Denise J. Cai, Ph.D. @denisejcai.bsky.social · 30/09/2026
NEW: The anterior hypothalamic nucleus acts like a volume knob for stress, scaling the brain’s response to threatening events 🧠 Read the Cai Lab's latest paper, led by @zachtpennington.bsky.social, in @nature.com 🎉 www.nature.com/articles/s41... More: bsky.app/profile/did:...
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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 30/09/2026
No more ANOVAs for the neurophysiologists!
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MwahahahahahadScientist @mads100tist.bsky.social · 30/09/2026
When your proposal gets killed by an algorithm that has no capacity to understand science, what will you do? When your colleague's proposal gets killed by an algorithm that has no capacity to understand science and amplifies biases by default, what will you do? That's where we're at 🧪
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Drew Schreiner @schreinerdrew.bsky.social · 30/09/2026
Sometimes procrastination pays off
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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 29/09/2026
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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 28/09/2026
most emails to all are baaaaaad news
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Guardian US @us.theguardian.com · 28/09/2026
"The US has grown used to the swift and dramatic erosion of women’s health and status that has followed Dobbs," writes @moiradonegan.bsky.social, "to the horror stories and upward ticking body counts, grown into ease, and even a kind of compliant boredom, with women’s death and indignity."
theguardian.com
Why has abortion faded from America’s national conversation? | Moira Donegan
The US has already grown used to the horror caused by abortion bans. And Republicans have sought to quash the stories
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Phil Klinkner @pklinkne.bsky.social · 28/09/2026
I really love this chart. I'm guess that the correlation here (.85) is about as big as you would find for any other variable. Also, a less serious scholar than @tesler.bsky.social (namely me) would have made a crude Freudian reference to the slope of the line.
Chart shows a close positive relationship between Trump's 2024 vote and Google searches for testosterone boosters.
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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 28/09/2026
This feels like the modern neuroscience equivalent of "there's no way anyone wrote 10-page essays without chatgpt"
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Vinny Costa @vincentcostaphd.bsky.social · 28/09/2026
Someone tell the AI biology labs that the best place to buy antibodies is from Santa Cruz.
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