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Mark Toshner

@mark-toshner.bsky.social
800 followers 402 following 241 posts

Prof @Cambridge/ Director VPD HLRI Clin Res Facility/ expert faultitasker/ trades in barely informed science opinions/ views are personal

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Mark Toshner @mark-toshner.bsky.social · 10/06/2026
I wonder if my family will stop thinking I’m daft as a brush now I am Prof of Cardiorespiratory Medicine in Cambridge? Scratch that. I already know the answer.
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Kurt @kurtprins.bsky.social · 30/05/2026
www.jci.org/articles/vie.... Our attempt to take in end-organ dysfunction with the liver as our focus in PAH/RV Failure. @jci.org @natrevgastrohep.nature.com @the-asci.org @mark-toshner.bsky.social
jci.org
JCI - Pulmonary Arterial Hypertension Induces a Metabolic and Inflammatory Hepatopathy
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Mark Toshner @mark-toshner.bsky.social · 24/05/2026
Paper drop where we question the mechanism of action of sotatercept. Think this will only get more important as the drug does lots of interesting things. pubmed.ncbi.nlm.nih.gov/42160453/
pubmed.ncbi.nlm.nih.gov
Sotatercept reduces bone morphogenetic protein signaling in patients with pulmonary arterial hypertension - PubMed
Pulmonary arterial hypertension (PAH) is a rare, life-limiting disease where imbalances in the transforming growth factor-β (TGF-β) and bone morphogenetic protein receptor type II (BMPR-II) superfamil...
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Mark Toshner @mark-toshner.bsky.social · 02/03/2026
You will not find a clearer thinker and good human being to boot. Medical leadership is painfully difficult and unfortunately full of mediocrity at an important time for the profession. Vote for someone better! bsky.app/profile/drlk...
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Kit Byatt @kitb.bsky.social · 17/02/2026
An excellent candidate IMO, careful, thoughtful, and passionate about training enough high quality doctors.
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Dr Louella Vaughan @drlkvaughan.bsky.social · 02/03/2026
Voting opens today for @rcphysicians.bsky.social elections. I am standing for Vice President for Education and Training. It's the first elections where Members will also be able to vote. Please encourage all eligible to exercise their franchise. More about me here: tinyurl.com/22j7nypk
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ATS Blue Journal @atsblueeditor.bsky.social · 18/02/2026
The Blue Journal thanks Eckart De Bie, MD, MPhil, for his contribution to the January issue Inflammation and Obesity Correlate in Pulmonary Hypertension but Associate with Diverging Outcomes @mark-toshner.bsky.social academic.oup.com/ajrccm/artic...
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Mark Toshner @mark-toshner.bsky.social · 29/11/2025
Every once in a while awards committees get it right! If there is a more deserving person out there of this than Marc Humbert, I don’t know them! eur03.safelinks.protection.outlook.com?url=https%3A...
eur03.safelinks.protection.outlook.com
Marc Humbert : Pulmonary Arterial Hypertension, The Battle of a Committed Doctor · Inserm
Inserm Grand Prize winner, lung specialist and researcher Marc Humbert has devoted his career to deciphering the mechanisms of pulmonary arterial hypertension. From disease characterization to the cre...
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Gregg Gonsalves @gregggonsalves.bsky.social · 22/09/2025
The @washingtonpost.com story on Tylenol & autism leaves out a MAJOR 2.5M sibling-controlled study of children in Denmark, which "found no evidence that acetaminophen use during pregnancy was associated with children’s risk of autism, ADHD or intellectual disability." jamanetwork.com/journals/jam...
jamanetwork.com
Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability
This nationwide cohort study with sibling control analysis examines the association of acetaminophen use during pregnancy with children’s risk of autism, ADHD, and intellectual disability.
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Mark Toshner @mark-toshner.bsky.social · 15/07/2025
After our mammoth international patient engagement work- some actions for the global community to consider pubmed.ncbi.nlm.nih.gov/40662200/
pubmed.ncbi.nlm.nih.gov
Pulmonary Hypertension Global Patient Survey: A Call to Action 2025 - PubMed
Pulmonary Hypertension Global Patient Survey: A Call to Action 2025
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The Washington Post @washingtonpost.com · 07/07/2025
The United States has recorded its highest annual measles cases in 33 years. The milestone marks a public health reversal in defeating a highly contagious, vaccine-preventable disease as the anti-vaccine movement gains strength.
washingtonpost.com
U.S. measles cases reach 33-year record high as outbreaks spread
Johns Hopkins University data reflects the public health reversal in defeating the vaccine-preventable disease since measles was officially eliminated from the U.S. in 2000.
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Mark Toshner @mark-toshner.bsky.social · 06/07/2025
First ever international survey of patients with pulmonary hypertension. Wonderful collaborative work. Lots of important and useful insights. t.co/XTvpbS4g8Y
t.co
https://doi.org/10.1183/23120541.00297-2025
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NIHR Biomedical Research Centre: Cambridge @cambridgebrc.bsky.social · 18/06/2025
@mark-toshner.bsky.social
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Mark Toshner @mark-toshner.bsky.social · 19/06/2025
My excellent student winning the best type of award. One for actually remembering the patient in amongst our research! bsky.app/profile/camb...
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NIHR Biomedical Research Centre: Cambridge @cambridgebrc.bsky.social · 18/06/2025
AND FINAL CONGRATULATIONS to @cam.ac.uk MPhil student Vidisha Handoo, whose poster was voted the best of those on display at last week's Cambridge #PPI Showcase day @angliaruskin.bsky.social @cuh.nhs.uk Thanks to ALL our presenters & poster submissions, you were all great! 3/3
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Mark Toshner @mark-toshner.bsky.social · 09/06/2025
Glasgow. Where the people are funniest because the weather is no joke. Good to be home!
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Dr Lucy Foulkes @lucyfoulkes.bsky.social · 21/05/2025
I’m in the Guardian today, arguing that we should stop them all-class mental health lessons in schools I've thought very carefully about ‘going public’ with this, because it's a sensitive argument to make, especially in the face of so many young people struggling. (cont 🧵) tinyurl.com/vun92cz7
theguardian.com
Mental-health lessons in schools sound like a great idea. The trouble is, they don’t work | Lucy Foulkes
All-class therapy sessions don’t help, and may even make matters worse. The evidence shows we need different solutions, says Dr Lucy Foulkes, an academic psychologist at Oxford University
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Kurt @kurtprins.bsky.social · 16/05/2025
www.ahajournals.org/doi/10.1161/.... Our most recent work attacking RV failure! @mark-toshner.bsky.social @ahascience.bsky.social @ahajournals.bsky.social
ahajournals.org
Lactobacillus Restructures the Micro/Mycobiome to Combat Inflammation-Mediated Right Ventricular Dysfunction in Pulmonary Arterial Hypertension | Circulation: Heart Failure
BACKGROUND: Inflammation suppresses right ventricular (RV) function in pulmonary arterial hypertension (PAH). In particular, we showed GP130 (glycoprotein-130) signaling promotes pathological microtub...
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Mark Toshner @mark-toshner.bsky.social · 24/04/2025
That joyous moment when you get rid of the 🐵 on your back, AKA submitting that 27 page rebuttal after 9 months of revisions… 🎉 images.squarespace-cdn.com/content/v1/5...
images.squarespace-cdn.com
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PVRI @pvrinstitute.bsky.social · 23/04/2025
⭐️Meet the speaker⭐️ We’re delighted to have @mark-toshner.bsky.social joining #DDDS2025, who will be speaking on 'How to define or prove disease modification'.
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Mark Toshner @mark-toshner.bsky.social · 03/04/2025
I think most senior doctors in UK in positions of importance/power have just turned away rather than consider how terribly demoralised the trainees are by the current awful system.
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Mark Toshner @mark-toshner.bsky.social · 01/04/2025
Quite a stunning result this. Sotatercept in severe pulmonary arterial hypertension www.nejm.org/doi/full/10....
nejm.org
Sotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death | NEJM
Sotatercept improves exercise capacity and delays the time to clinical worsening in patients with World Health Organization (WHO) functional class II or III pulmonary arterial hypertension. The eff...
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Mark Toshner @mark-toshner.bsky.social · 30/03/2025
‘My dad is so cringe’. I’ve reached peak parenting
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VPD Heart & Lung Research Institute @vpd-hlri.bsky.social · 25/03/2025
🎥 Highlights from yesterday's VPD-HLRI Monthly Seminar! Great talks by Prof. Jason Gill from @uofglasgow.bsky.social and our very own Prof. Murray Clarke. Thanks to our speakers and attendees! #HLRI #MetabolicHealth #VascularInflammation @cambridgeuni.bsky.social @murrayclarkelab.bsky.social
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Mark Toshner @mark-toshner.bsky.social · 23/03/2025
Just gave a talk with the absolute brightest lights I’ve ever had blinding me from back of auditorium. Really affected my game!
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Mark Toshner @mark-toshner.bsky.social · 21/03/2025
The view from Adelaide convention centre is a bit special eh?!
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Mark Toshner @mark-toshner.bsky.social · 14/03/2025
Very excited to share our work in Imatinib in PAH. Read on for the TLDR t.co/q7Uyg8uRdJ
t.co
https://pubmed.ncbi.nlm.nih.gov/40080796/
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Mark Toshner @mark-toshner.bsky.social · 14/03/2025
Very excited to share our work in Imatinib in PAH. Read on for the TLDR t.co/q7Uyg8uRdJ
t.co
https://pubmed.ncbi.nlm.nih.gov/40080796/
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VPD Heart & Lung Research Institute @vpd-hlri.bsky.social · 14/03/2025
Longer term post-hospital morbidity and mortality following admission with Covid-19: A systematic review and meta-analysis. publications.ersnet.org/content/erjo... @charlottesummers.bsky.social @mark-toshner.bsky.social @lukeflower.bsky.social
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Kathleen Bachynski @bachynski.bsky.social · 12/03/2025
“Johns Hopkins has bet very heavily on a century & a quarter of partnership with the federal government,” said Dr. Theodore Iwashyna, a critical-care physician… “If the federal government decides it doesn’t want to know things anymore, that would be bad for Johns Hopkins & devastating for Maryland.”
wsj.com
Johns Hopkins Plans Staff Layoffs After $800 Million Grant Cuts
Local and international health research efforts are already winding down as the university braces for even more potential cuts.
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Mark Toshner @mark-toshner.bsky.social · 08/03/2025
In other news- NASA to investigate flat earth claims www.nytimes.com/2025/03/07/h...
nytimes.com
C.D.C. Will Investigate Debunked Link Between Vaccines and Autism
Dozens of studies have failed to find evidence of a link. The decision to re-examine the question comes as a measles outbreak, driven by low vaccination rates, widens in Texas.
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Mark Toshner @mark-toshner.bsky.social · 08/03/2025
My great grandparents were immigrants to the UK (on both sides). At dinner with my 85 yr old uncle he told me a story that has been sitting with me and I’d like to share.
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Mark Toshner @mark-toshner.bsky.social · 08/03/2025
My great grandparents were immigrants to the UK (on both sides). At dinner with my 85 yr old uncle he told me a story that has been sitting with me and I’d like to share.
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Mark Toshner @mark-toshner.bsky.social · 05/03/2025
Edinburgh airport is, I note, taking a principled stand against US intolerance 🤣😂
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Mark Toshner @mark-toshner.bsky.social · 05/03/2025
This thread is a genuine off- the-cuff work of art
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Mark Toshner @mark-toshner.bsky.social · 05/03/2025
Edinburgh airport is, I note, taking a principled stand against US intolerance 🤣😂
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Mark Toshner @mark-toshner.bsky.social · 25/02/2025
Pulmonary hypertension peeps- I think we have produced a pretty definite paper nailing right heart structure, function and clinical outcomes? What do you think? t.co/B5yED7ypmI
t.co
https://www.medrxiv.org/content/10.1101/2025.02.13.25321996v1
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Mark Toshner @mark-toshner.bsky.social · 23/02/2025
Formal events and weddings. Definitely not enough being done to start conversations about the Witchcraft Act 1563
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Mark Toshner @mark-toshner.bsky.social · 23/02/2025
I really like this tartan, but imagine having to explain why you are wearing it at your friend’s wedding… wildhunt.org/2025/02/newl...
wildhunt.org
Newly Approved Tartan Design Memorializes Those Persecuted Under Scotland’s Witchcraft Act - Paganism, U.K., U.S., Witchcraft, World
Witchcraft & Pagan News - The Scottish Register of Tartans approves a new design by The Witches of Scotland, an organization seeking justice for those persecuted under the Witchcraft Act. | Paganism, ...
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Mark Toshner @mark-toshner.bsky.social · 18/02/2025
I’ve thought long and hard and here is my greatest achievement. I’ve had this badge for almost 20 years 🤣😂🤣
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Mark Toshner @mark-toshner.bsky.social · 14/02/2025
It never ceases to amaze how ‘bus-like’ journal submissions are. Have been submitting papers continuously for about 8 months with nothing much landing. 3-4 landed this week within 48hrs of each other. It’s a conspiracy… I stress test my mental health!!
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Mark Toshner @mark-toshner.bsky.social · 12/02/2025
Google rolling back on this slowly I see
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Mark Toshner @mark-toshner.bsky.social · 07/02/2025
If there are any editors out there hanging on to one of my manuscripts that aren’t about to be rejected, cheer me up this afternoon by pinging the email (and hold on to the rejections til Monday)
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Dr Yvonne Couch @dryvonnecouch.bsky.social · 03/02/2025
Stolen from LinkedIn... 🧪
Pie chart with four coloured segments (green, red, blue, yellow - red is the largest, the others are roughly equal), legend below pie chart has four colours, none of which correspond to those in the pie chart and are labelled 'salary, wellness, stable mental health, confidence in your future'
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Mark Toshner @mark-toshner.bsky.social · 17/01/2025
Asking for a friend. If your wife bought these socks at Xmas and you accidentally wear them to work, would an HR complaint be A) upheld and rightly so B) dismissed out of hand…
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Mark Toshner @mark-toshner.bsky.social · 14/01/2025
The curse of full confidence strikes again…
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Mark Toshner @mark-toshner.bsky.social · 13/01/2025
Is there any public phrase less inspiring of confidence than “I have full confidence in…”
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Mark Toshner @mark-toshner.bsky.social · 13/01/2025
Middle age in the gym is just twinge roulette. Shall I keep going through this one or is it the one that cripples me and I can’t put in my socks tmw… do I feel lucky, punk. 🔫
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Mark Toshner @mark-toshner.bsky.social · 13/01/2025
Is there any public phrase less inspiring of confidence than “I have full confidence in…”
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Mark Toshner @mark-toshner.bsky.social · 12/01/2025
Winter on the bike!
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