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marius walter

@mariusw.bsky.social
331 followers 564 following 70 posts

Virologist at the Fred Hutch Cancer Center, Seattle. 🇫🇷 living in 🇺🇸. He/him.

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Reposted by marius walter
Fred Hutch @fredhutch.org · 05/02/2026
The @jimboonya.bsky.social lab at Fred Hutch found the use of sirolimus #GVHD prophylaxis in allo HCT recipients was linked to a higher risk for RSV infection, whereas higher serum neutralizing antibody levels were linked to a lower risk in the first 100 days post-transplant. wb.md/3Zokzua
wb.md
RSV Antibody Levels Tied to Posttransplant Infection Risk
After hematopoietic cell transplant, sirolimus use for GVHD prophylaxis is linked to a higher RSV risk, whereas higher serum neutralizing antibody levels are tied to a lower risk within 100 days.
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Reposted by marius walter
Harmit Singh Malik @harmitmalik.bsky.social · 17/01/2026
Getting asked about how academics can continue to do science & inspire trainees even in the midst of a continued (escalated) assault on science, reason, truth, & human rights. I don’t have great answers. I would love to hear from mentors about advice they’re giving to trainees/ colleagues.
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Marc Veldhoen @marcveld.bsky.social · 09/10/2025
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging Naked mole rats get much older than closely related mamals of a similar size. cGAS mutations may have an important role in this. www.science.org/doi/... 1/9
science.org
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that naked mole-rat cyclic guanosine monophosphate–adenosine ...
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Sofya Garushyants @garushyants.bsky.social · 15/09/2025
hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!
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Juliane Glaser @julianeg.bsky.social · 04/09/2025
🥳 Very grateful for the support of the ERC Starting Grant for my newly established lab! We will study how transposable elements contribute to mammalian embryonic development. We will have positions available next year. Stay tuned!
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Michael Hobbes @michaelhobbes.bsky.social · 21/08/2025
Super interesting deep dive into US excess mortality. We're doing better than we were in 1980 but a *lot* worse than every other high-income country. jamanetwork.com/journals/jam...
Mortality Rates, Mortality Rate Ratios, and Excess US Deaths Attributable to the US Mortality Disadvantage Relative to Other High-Income Countries (HICs)
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Anna A Monaco @annaamonaco.bsky.social · 23/07/2025
Pretty surreal to see my artwork on the cover of Nature Genetics! Big congrats to @julianeg.bsky.social, @stemundi.bsky.social and the others, and thank you Juliane for letting me help bring your research to life visually. www.nature.com/ng/volumes/5...
The cover of Nature Genetics July 2025 issue. Digital art of a mouse paw skeletal prep on dark background, digits I to IV disintegrating into viral particles. A caption says “An endogenous retrovirus causes limb malformation”.
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Viroscope @viroscope.bsky.social · 10/05/2025
⚠️ Discovery of a new mode of viral transmission: Deltaviruses spread through a viral Trojan Horse ! These viral satellites that do not encode their own glycoproteins, are in fact physically encapsulated within their helper virus particles! www.biorxiv.org/content/10.1... A thread 1/14
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Sebastian S. Cocioba @atinygreencell.bsky.social · 02/05/2025
I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs. Plant, Bacterial, Archaeal Non-model Bioeng Custom Lab Hardware Turn Key Genetic Design Please repost for reach 💚
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Zebrafish Rock! @zebrafishrock.bsky.social · 24/04/2025
I always like to reference this comparison chart that @rrbehringer.bsky.social made awhile back. Hope it helps put things in perspective! -KT
Various shapes and sizes of animal zygotes
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Jenny Cohn @jennycohn.bsky.social · 22/03/2025
“One young man sobbed when a guard pushed him to the floor. He said, ‘I’m not a gang member. I’m gay. I’m a barber.’ I believed him. *** He “began to whimper,” as his head was roughly shaved, “folding his hands in prayer as his hair fell.” He “asked for his mother & cried as he was slapped again.”
time.com
What the Venezuelans Deported to El Salvador Experienced
Exclusive photos of the arrival of Venezuelan detainees deported from the U.S.
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Yvette Cendes @whereisyvette.bsky.social · 16/03/2025
Pet peeve: I hate how often ppl claim “all the researchers will just move to Europe/Canada!” You vastly under-estimate how little money there is there vs the USA- and unless that changes ASAP this loss is just going to decimate global science, full stop. 🧪🔭
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Nome @nome.bsky.social · 12/03/2025
I have been doing entirely too much earnest posting about deep things recently, I need to do a proper thread about hippo testicles or something just to keep myself sane. Oh by the way hippos have migratory testicles.
media.tenor.com
a statue of a hippopotamus with its mouth open and teeth showing .
Alt: A hippo being tossed a watermelon, which it crushes in its massive jaws.
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marius walter @mariusw.bsky.social · 04/03/2025
This is the content we need right now
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Reposted by marius walter
Melody Schreiber @melodyschreiber.com · 04/03/2025
he was afraid of needles! absolute legend www.npr.org/2025/03/03/n...
npr.org
James Harrison, whose blood donations saved over 2 million babies, has died
Harrison, whose plasma contained a rare antibody, rolled up his sleeve 1,173 times from 1954 to 2018. The Australian is credited with helping 2.4 million babies and advancing scientific research.
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marius walter @mariusw.bsky.social · 26/02/2025
I feel virology Bluesky should be talking about that www.nytimes.com/2025/02/25/w...
nytimes.com
Unknown Deadly Illness Strikes Western Congo (Gift Article)
The outbreak has been traced, tentatively, to three children who ate a bat, the W.H.O. said, and known threats like Ebola and Marburg have been ruled out.
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Reposted by marius walter
Meredith Whittaker @meredithmeredith.bsky.social · 19/02/2025
Stand by this: www.politico.com/newsletters/...
What’s a technology that you think is overhyped?

I’m going to give a sideways answer to this, which is that the venture capital business model needs to be understood as requiring hype. You can go back to the Netscape IPO, and that was the proof point that made venture capital the financial lifeblood of the tech industry.

Venture capital looks at valuations and growth, not necessarily at profit or revenue. So you don’t actually have to invest in technology that works, or that even makes a profit, you simply have to have a narrative that is compelling enough to float those valuations. So you see this repetitive and exhausting hype cycle as a feature in this industry. A couple of years ago, you would have been asking me about the metaverse, then last year, you would have asked me about Web3 and crypto, and for each of these inflection points there’s an Andreessen Horowitz manifesto.

It’s not simply that one piece of technology is overhyped, it’s that hype is a necessary ingredient of the current business ecosystem of the tech industry. We should examine how often the financial incentive for hype is rewarded without any real social returns, without any meaningful progress in technology, without these tools and services and worlds ever actually manifesting. That’s key to understanding the growing chasm between the narrative of techno-optimists and the reality of our tech-encumbered world.
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Katie Sandlin @kmsandlin.bsky.social · 14/02/2025
I maxed out my credit card, emptied my savings account, and took out a loan to move from Alabama to Bethesda, MD. I don’t even qualify for unemployment since I’ve only worked at NIH for a month. I will be financially and medically devastated. Seeking suggestions for anywhere that’s hiring!!
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Carl T. Bergstrom @carlbergstrom.com · 06/02/2025
Powerful, provocative piece from @cbo.bsky.social this morning.
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Derek Lowe @dereklowe.bsky.social · 05/02/2025
I’ve unfortunately needed to add more material to my post from yesterday. The re-election of Donald Trump is looking like the biggest act of American self-destruction since the Civil War. Same link, new title and some updates.
science.org
Revised and Extended: What's Happening Inside the NIH and NSF
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marius walter @mariusw.bsky.social · 25/01/2025
I love to see our work pops up in my feed! Glad you liked our paper and thank you for sharing it
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TAU-Virology @tauvirology.bsky.social · 25/01/2025
New hope for viral coinfection-based therapeutic approach against Herpesviruses! Gene Drive(GD), a self propagating gene-editing technique via Cas9 mediated homologous recombination inserts the GD with red fluorescent (mCherry) into HSV-1 genome. Specific and non-specific (GD-ns) gRNA were tested.
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Raquel Pérez Palacios @rqperezpalacios.bsky.social · 13/01/2025
Hello! this is my first post in Bluesky :) Like many of you, I have migrated here to share, connect and stay updated on everything happening in the world of science (although epigenetics and embryology–developmental biology are my absolute favorites!). Let's get started!
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Harmit Singh Malik @harmitmalik.bsky.social · 16/12/2024
Full stream ahead: how one couple is leveraging their love of science to inspire support for research at Fred Hutch www.fredhutch.org/en/news/cent...
fredhutch.org
Full stream ahead
Balint and Lita, the husband-and-wife team behind SciAnts Streams, are among a growing number of people who are using their digital platforms — including live gaming and educational streams — to conne...
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marius walter @mariusw.bsky.social · 18/11/2024
Hi to my new followers! I am a virologist at @fredhutch.bsky.social in the team of Keith Jerome. If you are curious about what I do here are 3 options for you: 1. Read our latest paper! We showed that a viral gene drive propagated during HSV-1 infection in mice www.nature.com/articles/s41...
nature.com
Viral gene drive spread during herpes simplex virus 1 infection in mice - Nature Communications
Gene drives are genetic modifications designed to propagate efficiently through a population. Here, the authors develop a viral gene drive against herpes simplex virus 1 (HSV-1) and show that it propa...
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Marc Somssich @somssich.bsky.social · 20/05/2024
Do you know who Douglas Prasher is? Many don't, even though he is the person who cloned the original #GFP gene in the late 1980s. In my short history of plant light #microscopy I also cover a bit of his story - & why he is relatively unknown today, despite the importance of his work. See this 🧵👇
A profile picture of Douglas Prasher from Martin Chalfie's Nobel Lecture
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marius walter @mariusw.bsky.social · 11/12/2023
Giving a first try at Bluesky: We are excited share our latest work! We designed a viral gene against HSV-1 and showed that it spread efficiently during infection in mice www.biorxiv.org/content/10.1...
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