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Nikos Margaritelis

@margaritelis.bsky.social
79 followers 92 following 12 posts

Associate Professor at Aristotle University of Thessaloniki, Greece

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Reposted by Nikos Margaritelis
Michalis Nikolaidis @mg-nikolaidis.bsky.social · 22/08/2026
1/13 How many calories does it take to build 1 kg of muscle? The question is straightforward but, as far as we can tell, it has not yet been answered quantitatively. www.biorxiv.org/content/10.6...
biorxiv.org
The Energetic Cost of Building Human Skeletal Muscle
The energetic cost of building human skeletal muscle has never been explicitly calculated or measured. We developed a quantitative bottom-up accounting model that integrates human skeletal-muscle comp...
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Chrysostomos Sahinis @sahinischrysosto.bsky.social · 18/04/2025
🚨 Our new meta-analysis is out in Journal of Sports Sciences! We reviewed 40 studies comparing semitendinosus vs. biceps femoris activation during hamstring strengthening exercises (knee vs hip based). doi.org/10.1080/0264... Here's what we found 🧵👇 #hamstrings
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Wolfgang Viechtbauer @wviechtb.bsky.social · 22/06/2026
As another alternative to the standard forest plot for visualizing many effect size estimates in a meta-analysis, one can use 'orchard plots' (Nakagawa et al., 2021). Example code to create such figures can be found here: www.metafor-project.org/doku.php/plo... #MetaAnalysis #RStats
An orchard plot showing many effect size estimates clustered by a categorical moderator variable, with pooled estimates (with 95% CIs/PIs) within subgroups superimposed.
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Michalis Nikolaidis @mg-nikolaidis.bsky.social · 03/05/2026
When vitamin C levels are low, correcting them makes sense. But in this study, we found no evidence that each person needs a personalized vitamin C supplementation.
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Nikos Margaritelis @margaritelis.bsky.social · 28/04/2026
Happy to share our publication in FRBM. We used aggregated sets of n-of-1 trials to study individual oxidative stress & inflammation responses to vit C supplementation. Huge thanks to @lorenzololli.bsky.social @gregatki.bsky.social @mg-nikolaidis.bsky.social www.sciencedirect.com/science/arti...
sciencedirect.com
Individual oxidative stress and inflammation responses to vitamin C supplementation: Aggregated sets of n-of-1 trials
Personalized antioxidant supplementation is promoted to optimize redox balance and inflammation profile.To quantify the short-term effects of vitamin …
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Nikos Margaritelis @margaritelis.bsky.social · 03/10/2025
Our new paper with @mg-nikolaidis.bsky.social out in @cp-trendsmolecmed.bsky.social “Science captured by storytelling: the oxidative stress narrative” DOI: authors.elsevier.com/a/1lt2w5Eb1B...
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International Journal of Sport Nutrition and Exercise Metabolism @hk-ijsnem.bsky.social · 23/09/2025
🚨LEAD FEATURE ARTICLE🚨 November 2025✨ We are very excited to announce our lead feature article for the November 2025 by Lolli et al titled ‘Understanding Treatment Response Heterogeneity Using Crossover Randomized Controlled Trials: A Primer for Exercise and Nutrition Scientists’.
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Paraskevi Kritsiligkou @parikki.bsky.social · 04/09/2025
sciencedirect.com
Metabolic dysfunction-associated steatohepatitis reduces hepatic H2S-producing enzymes altering persulfidome composition
Metabolic dysfunction–associated steatohepatitis (MASH) is a progressive disease driven by obesity-related hepatic inflammation and oxidative stress. …
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Reposted by Nikos Margaritelis
Greg Atkinson @gregatki.bsky.social · 28/08/2025
It was a rewarding labour of love to work on this paper with a fantastic team of authors, “Understanding Treatment Response Heterogeneity Using Crossover Randomized Controlled Trials: A Primer for Exercise and Nutrition Scientists”. @hk-ijsnem.bsky.social journals.humankinetics.com/view/journal...
journals.humankinetics.com
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Greg Atkinson @gregatki.bsky.social · 01/08/2025
This is a very interesting study comparing physiological variables between two phases of the menstrual cycle across two whole cycles. The design resembles a replicate crossover trial which enables proper study of individual responses. physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com
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anamledo.bsky.social @anamledo.bsky.social · 26/06/2025
2nd Redox Medicine Workshop ... Meet the Speakers: More info: redoxmedicine2025.febsevents.org Important dates: July 1 - SFRR-E and FEBS Fellowships Applications; July 20 - Abstract Submission (General Track) @sfrre-ecr.bsky.social @ucoimbra.bsky.social @febsjuniorsection.bsky.social
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Nikos Margaritelis @margaritelis.bsky.social · 09/06/2025
I'm grateful to the SFRR-E for the ECR Fellowship (@sfrre-ecr.bsky.social) which made the RedoxOne project a reality. Otherwise, it would still be an idea saved in the “future studies” word file! #redox #antioxidants #exercise #nutrition #Nof1 #interindividual_variability #galway
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Reposted by Nikos Margaritelis
Michalis Nikolaidis @mg-nikolaidis.bsky.social · 29/05/2025
Vitamin C+E supplementation blunts molecular adaptations to sprint interval training but not performance gains. Since performance wasn’t impaired, I wonder whether, and to what extent, the blunted molecular responses can truly be considered detrimental physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com
Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres
Abstract figure legend Sprint interval training (SIT) is a popular time-efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all-out cycling sprints) over 3...
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Reposted by Nikos Margaritelis
Greg Atkinson @gregatki.bsky.social · 27/05/2025
After very valuable comments from referees, here's the revised preprint for our paper "Understanding treatment response heterogeneity using randomised crossover trials: A primer for exercise and nutrition scientists" (@lorenzololli.bsky.social @j-t-gonzalez.bsky.social et al) osf.io/preprints/os...
osf.io
OSF
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Reposted by Nikos Margaritelis
Erik van Zwet @erik-van-zwet.bsky.social · 08/05/2025
There's a nice discussion at Frank Harrell's datamethods: discourse.datamethods.org/t/dichotomiz...
discourse.datamethods.org
Dichotomization
I’m writing a paper about “An Empirical Assessment of the Cost of Dichotomization” together with Frank Harrell (@f2harrell) and Stephen Senn (@Stephen). In this paper, we quantify the information loss...
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Reposted by Nikos Margaritelis
SFRR-E_ ECRs @sfrre-ecr.bsky.social · 05/05/2025
Join us for a special ECR SFRR Webinar focused on Mental Health in Research by Amal Ibrahim. Date: Tuesday 6th May 2025 Time: 15:00 CET Where: Online (link in bio) #MentalHealthInScience #ECRSFRR #WellbeingInResearch #FreeRadicalResearch #AcademicLife #PhDlife #PostdocLife #ScienceCommunity
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Reposted by Nikos Margaritelis
Greg Atkinson @gregatki.bsky.social · 30/04/2025
Hats off to them for publishing that paper without mentioning n-of-1 trials or person-by-treatment interactions 😬. We've this paper currently under review. It's frustratingly long-winded, but that's the complex nature of the precision nutrition beast I suppose, osf.io/preprints/os...
osf.io
OSF
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Michalis Nikolaidis @mg-nikolaidis.bsky.social · 23/04/2025
James Imlay turns redox chaos into clockwork: his new paper shows how membrane permeability sets the tempo of oxidative stress, with straight-up back-of-the-envelope math in the appendix. Fundamental, elegant, causal. onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
The Barrier Properties of Biological Membranes Dictate How Cells Experience Oxidative Stress
Molecular oxygen diffuses across membranes with such speed that, despite respiration, the intracellular oxygen concentration does not differ significantly from that outside the cell. In contrast, mem...
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Reposted by Nikos Margaritelis
Vanesa Cepas López @cepaslopez.bsky.social · 31/03/2025
📢 Exciting Webinar Alert! Join us tomorrow, April 1st, at 15:00 CET for an unmissable webinar on chaperones in redox biology, hosted by @sfrre-ecr.bsky.social! We’re thrilled to welcome two fantastic speakers: @ulrichlab.bsky.social and @rsutandy.bsky.social. See you there!
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Reposted by Nikos Margaritelis
Greg Atkinson @gregatki.bsky.social · 25/02/2025
Good to see this paper finally published in EJON, after a strange prior experience with another journal, "Inter-individual differences in the blood pressure lowering effects of dietary nitrate: a randomised double-blind placebo-controlled replicate crossover trial" link.springer.com/article/10.1...
link.springer.com
Inter-individual differences in the blood pressure lowering effects of dietary nitrate: a randomised double-blind placebo-controlled replicate crossover trial - European Journal of Nutrition
Purpose Dietary nitrate supplementation increases nitric oxide (NO) bioavailability and reduces blood pressure (BP). Inter-individual differences in these responses are suspected but have not been inv...
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Reposted by Nikos Margaritelis
Michalis Nikolaidis @mg-nikolaidis.bsky.social · 12/02/2025
Study shows that chronic antioxidant supplementation (VitC+VitE) blunted molecular adaptations to training, yet, no impact on any measure of exercise performance—considering that "antioxidant" is a vague term and that VitC+VitE may not always act as such. www.biorxiv.org/content/10.1...
biorxiv.org
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Vanesa Cepas López @cepaslopez.bsky.social · 31/01/2025
Great redox researcher to follow and excellent review in the redox biosensors field!
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Michalis Nikolaidis @mg-nikolaidis.bsky.social · 31/01/2025
Important study highlighting plausible molecular links between redox metabolism and exercise performance—an area notoriously difficult to dissect. The findings challenge assumptions that G6PD deficiency decreases exercise performance. A human replication study would be invaluable.
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Angelo D’Alessandro @dalessandrolab.bsky.social · 30/01/2025
G6PD deficiency affects 6% of humankind, predisposing RBCs to hemolysis after oxidant stress. Unexpectedly, humanized G6PD deficient mice do not hemolyze after oxidant stress post exercise, and tolerate exercise better! On the cover of @bloodadvances.bsky.social ashpublications.org/bloodadvance...
ashpublications.org
Increased exercise tolerance in humanized G6PD-deficient mice
Key PointsG6PD-deficient mice maintain higher exercise speeds without increased red blood cell hemolysis, questioning assumed risks.Increased cardiac outpu
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Nikos Margaritelis @margaritelis.bsky.social · 30/01/2025
Our contribution to the Special Issue "Unlocking Athletic Potential: Exploring Exercise Physiology from Mechanisms to Performance" in FRBM, Guest-edited by Prof. Gomez-Cabrera & @c-handschin.bsky.social #redox #supplements #sports #evidence
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Christoph Handschin @c-handschin.bsky.social · 30/01/2025
“Evidence-based sports supplements: A redox analysis” by @margaritelis.bsky.social, @parikki.bsky.social, @mg-nikolaidis.bsky.social and colleagues. www.sciencedirect.com/science/arti... 10/17
sciencedirect.com
Evidence-based sports supplements: A redox analysis
Despite the overwhelming number of sports supplements on the market, only seven are currently recognized as effective. Biological functions are largel…
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Christoph Handschin @c-handschin.bsky.social · 30/01/2025
“Unlocking Athletic Potential: Exploring Exercise Physiology from Mechanisms to Performance” in FRBM is complete! Reviews on exercise physiology, muscle plasticity, molecular mechanisms and more! All #openaccess! #myoblue #muscle #exercise www.sciencedirect.com/special-issu... A long🧵: 1/17
sciencedirect.com
Free Radical Biology and Medicine | Unlocking Athletic Potential: Exploring Exercise Physiology from Mechanisms to Performance | ScienceDirect.com by ElsevierScienceDirect
Exercise training involves repeated exposure to increases in metabolic, thermal, mechanical, and oxidative stress. This exposure stimulates physiological adaptations that improve tolerance to similar ...
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Paraskevi Kritsiligkou @parikki.bsky.social · 24/01/2025
The editorial mentoring programme of the @sfrre-ecr.bsky.social is now running! Seeing initiatives we envisioned coming to fruition is always quite emotional! Wishing the best of success to the mentees for their journey ahead! Many thanks to senior editors of Redox Biology, FRBM and RBC, &elsevier!
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Peder M Isager @isager.bsky.social · 20/12/2024
New preprint: “Three-Sided Testing to Establish Practical Significance: A Tutorial” (osf.io/preprints/ps...) with @FitzgeraldJack_, proposing an upgraded version of the TOST equivalence test 🧵
osf.io
OSF
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Angelo D’Alessandro @dalessandrolab.bsky.social · 22/12/2024
99% of the circulating cells, 84% of the cells in the body are RBCs. These 25 trillion cells shed 1 vesicle/h (more under stress). With >250 transporters and receptors, RBCs pick up/release metabolites, at times even against gradient, throughout the body. Yet, they are not part of 👇 conversation
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Paraskevi Kritsiligkou @parikki.bsky.social · 12/12/2024
We are delighted to see our work setting up the Early Career Researcher subcommittee of the SFRR-E @sfrre-ecr.bsky.social being recognised! FEBS gave us an opportunity to summarise our achievements so far network.febs.org/posts/what-i... Big thanks to past and present members for their efforts!
network.febs.org
What is the ECR subcommittee of the SFRR-Europe up to? The new kid on the block
The Society for Free Radical Research - Europe (SFRR-Europe) is dedicated to promoting interest in all aspects of research related to Free Radicals in any scientific field. Their Early Career Research...
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Nikos Margaritelis @margaritelis.bsky.social · 10/12/2024
Meta reports plasma [NO3−] (μmol/L) & [NO2−] (nmol/L): - at cardiometabolic risk 21.2 [95%CI, 13.4–29.0] & 122.8 [95%CI, 75.3–138.9] - health 33.9 [95%CI, 29.9–37.9] & 159.5 [95%CI, 131.8–187.1] - trained 43.0 [95%CI, 13.2–72.9] & 199.3 [95%CI, 117.6–281] www.sciencedirect.com/science/arti...
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Nikos Margaritelis @margaritelis.bsky.social · 10/12/2024
#redox #new #neurons #vitamins #oxygen 🍊Distinct roles of ascorbic acid in extracellular vesicles and free form www.sciencedirect.com/science/arti... 🩸H2O2 diffusion across the RBC membrane www.sciencedirect.com/science/arti... 💨Oxygen control in cell culture www.sciencedirect.com/science/arti...
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Nikos Margaritelis @margaritelis.bsky.social · 30/11/2024
Personalized redox biology: Designs and concepts #redox #biology #antioxidants #ROS #free_radicals #personalized pubmed.ncbi.nlm.nih.gov/37541453/
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Vanesa Cepas López @cepaslopez.bsky.social · 29/11/2024
If you are looking for some redox inspiration to finish the week, this is a must-read! 🔍 Congratulations to @riemerlab.bsky.social and all of the authors for such an interesting paper, it's great to see it published!
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Michalis Nikolaidis @mg-nikolaidis.bsky.social · 25/11/2024
Free radicals and antioxidants: appealing to magic Our short paper argues that molecules cannot be classified as good or evil. Limited evidence supporting the consumption of antioxidants or superfoods and such interventions risk disrupting fundamental redox processes. www.cell.com/trends/endoc...
cell.com
Free radicals and antioxidants: appealing to magic
In biology, there are no good or evil molecules. There is limited or no evidence to support the consumption of antioxidants or (super)foods rich in antioxidants, for the intended purpose of an antioxi...
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