Antitumour immunity involves a complex balance of immune effectors and regulators, many of which are adapted or compartmentalised within the local mic…

Understanding regulation of progenitor exhausted CD8+ T (Tpex) cell differentiation is important for immunotherapies. Humblin et al. report that sustained ICOS costimulation is detrimental to PD-1+CD8...

Antigen-specific antibodies secreted by plasma cells are rapidly identified using microfluidics and fluorescence-activated cell sorting (FACS).

As proof of principle, an analysis using a suite of human-aligned immunocompetent mouse models of hepatocellular carcinoma identifies a promising therapeutic candidate, cladribine, which acts in a highly effective subtype-specific manner in combination with standard-of-care therapy.

Posted 10:45:46 AM. About usApplications are invited for a Postdoctoral Research Fellow position in the Division of…See this and similar jobs on LinkedIn.

Posted 10:45:46 AM. About usApplications are invited for a Postdoctoral Research Fellow position in the Division of…See this and similar jobs on LinkedIn.

Posted 10:45:46 AM. About usApplications are invited for a Postdoctoral Research Fellow position in the Division of…See this and similar jobs on LinkedIn.

Insights into how cancer cells become unresponsive to therapy.

Our interferon-associated signature of early SARS-CoV-2 infection characterises a subgroup of exposed, uninfected contacts in three independent cohorts who may have successfully aborted infection prior to induction of adaptive immunity. The earlier transient upregulation of signature genes in PCR-negative compared to PCR-positive CHIM volunteers suggests that ultra-early interferon-associated innate immune responses correlate with, and may contribute to, protection against SARS-CoV-2 infection.

PhD Project - EastBio: Long-range consequences of intestinal helminth infection. at University of Edinburgh, listed on FindAPhD.com

It’s not always clear whether blood biomarkers are differentially expressed in the time course of viral infections. In this SARS-CoV-2 human challenge study, the authors identify distinct single-gene ...

Tumor-antigen-specific CD8+ T cells are generally thought to help fight against cancer, but here the authors identify a subpopulation of CD8+ T cells that are associated with a poor clinical outcome i...

Abdelfattah et al. developed an engineering platform (T-Switch) for the creation, modification, and high-throughput profiling of T cell receptors (TCRs) to desired targets, particularly self-antigens....

Nature Immunology - In this Review, Herro and Grimes summarize the most recent key findings surrounding protective versus pathogenic functions of neutrophils, elaborating on phenotype-specific...

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).