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Fahri Küçükali

@maegsul.bsky.social
193 followers 304 following 9 posts

Postdoctoral researcher at @sleegerslab.bsky.social - VIB CMN working on complex genetics of Alzheimer's. | GWAS, molecular QTLs, TWAS, splicing, long reads, rare variants.

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Reposted by Fahri Küçükali
Sleegers Lab @sleegerslab.bsky.social · 15/09/2026
🧠🧬 New from our lab! Postdoc Celeste Laureyssen ( @celestelaureyssen.bsky.social ) reviews how neuropathology-centered GWAS can sharpen our understanding of the genetics of Alzheimer’s disease and its frequent co-pathologies—moving beyond clinical diagnosis alone. link.springer.com/article/10.1...
link.springer.com
A new era of genome-wide association studies in the field of Alzheimer’s disease and overlapping co-pathologies: lessons learned from a neuropathology-centered approach - Acta Neuropathologica
Alzheimer’s disease (AD) and overlapping pathologies represent a growing worldwide health concern. With the first disease-modifying treatments on the rise, it becomes increasingly important to move re...
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Fahri Küçükali @maegsul.bsky.social · 24/07/2026
Indeed! Very happy for the opportunity to talk about our latest work on tandem repeats and Alzheimer's disease risk at hashtag#AAIC26 in London last week 🧬🧠 A massive thank you to the Sleegers Lab team and all collaborators who made this work possible!
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Reposted by Fahri Küçükali
bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · 11/06/2026
inquiSTR: a toolkit for accurate and efficient population-scale tandem repeat genotyping and analysis www.biorxiv.org/content/10.64898/20…
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Fahri Küçükali @maegsul.bsky.social · 04/06/2026
Very happy to see this massive collaborative effort out! 🧬 www.nature.com/articles/s41...
nature.com
Consensus meta-analysis of genome-wide association studies for Alzheimer’s disease and related dementias - Nature Genetics
An updated meta-analysis of genome-wide association studies identified 91 risk loci for Alzheimer’s disease (AD) and related dementias among individuals of European ancestry, of which 56 loci were spe...
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Reposted by Fahri Küçükali
Sleegers Lab @sleegerslab.bsky.social · 04/06/2026
Also on our VIB CMN news portal here: cmn.sites.vib.be/en/news#/new...
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Sleegers Lab @sleegerslab.bsky.social · 04/06/2026
Out now in @natgenet.nature.com! Our latest GWAS meta-analysis identifies 91 risk loci for Alzheimer’s, deeply expanding our understanding of its genetic architecture. Proud of our team's contribution to this massive milestone! 🧠🧬🔬 @maegsul.bsky.social doi.org/10.1038/s415...
doi.org
Consensus meta-analysis of genome-wide association studies for Alzheimer’s disease and related dementias - Nature Genetics
An updated meta-analysis of genome-wide association studies identified 91 risk loci for Alzheimer’s disease (AD) and related dementias among individuals of European ancestry, of which 56 loci were spe...
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Reposted by Fahri Küçükali
Sleegers Lab @sleegerslab.bsky.social · 30/03/2026
Last Friday, the KS Lab attended the Stop Alzheimer (SAO) Young Researcher Congress in Mechelen 🧠 During the event, Fahri Küçükali gave an oral presentation and Nicole Natalia Wawrzyniak presented a poster. 📊 Once again, we thank SAO for their continued support of Alzheimer's research in Belgium!
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Fahri Küçükali @maegsul.bsky.social · 19/12/2025
Happy and honoured to receive the Fabrizio Caielli Award from the Carlo Besta Neurological Institute for our recent publication, “Multiomic analyses direct hypotheses for Creutzfeldt-Jakob disease risk genes” 🧠🧬 Many thanks to the selection committee for this recognition. 🔗 tinyurl.com/5y7nwp34
academic.oup.com
Multiomic analyses direct hypotheses for Creutzfeldt-Jakob disease risk genes
Küçükali & Hill et al. integrate GWAS data with transcriptome and proteome-wide association studies to better understand risk factors for sporadic Creu
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Reposted by Fahri Küçükali
Sleegers Lab @sleegerslab.bsky.social · 15/12/2025
Extremely thankful to have our Senior Research Project (with Julie van der Zee and @verwilt.bsky.social) funded in this @fwovlaanderen.bsky.social call! This marks a huge investment into our 1000 Healthy Elderly study in search of novel cell-free biomarkers! 🧠🧬🩸
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Fahri Küçükali @maegsul.bsky.social · 03/12/2025
Join us! 🧠🧬
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Reposted by Fahri Küçükali
Sleegers Lab @sleegerslab.bsky.social · 03/12/2025
HIRING ALERT!!! 💥 We are looking for an enthusiastic postdoctoral researcher to uncover Alzheimer's disease mechanisms using state-of-the-art technologies! 🧠🧬 jobs.vib.be/j/128109/pos...
jobs.vib.be
Postdoctoral Researcher in Computational Genomics of Alzheimers Disease - VIB
Description TheSleegers labat the VIB-UAntwerp Center for Molecular Neurology Belgium, is seeking a highly motivated and talented postdoctoral r
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Reposted by Fahri Küçükali
Sleegers Lab @sleegerslab.bsky.social · 28/10/2025
Last Friday, we shared our research with 1st year Master's students at @uantwerpen.be during the Research Day! We loved their genuine interest and look forward to welcoming several of them to our lab next year. Great to see Ph.D. students Kato and Ella share their love for science! 🧪
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medRxivpreprint @medrxivpreprint.bsky.social · 23/10/2025
Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementia www.medrxiv.org/content/10.1101/202…
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cmn-vib.bsky.social @cmn-vib.bsky.social · 09/10/2025
The European Alzheimer & Dementia Biobank (EADB) unites cohorts across 18 countries to decode the genetics of Alzheimer’s disease. eadb.eu At CMN, the @sleegerslab.bsky.social plays a leading role, with postdoc Fahri Küçükali as our in-house EADB specialist. #CMNcohorts #CMNconsortia
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Jasper Verwilt @verwilt.bsky.social · 07/10/2025
1 year of 1000 Healthy Elderly Study! As we are closing in on 200 re-inclusions, we took some time to celebrate this amazing milestone. Find more about our study here: bit.ly/4gV9TLk
bit.ly
News
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Reposted by Fahri Küçükali
Sleegers Lab @sleegerslab.bsky.social · 07/10/2025
One year in, nearly 200 re-inclusions and a clearer picture of healthy brain aging! The 1000 Healthy Elderly Study has become a real engine for discovery. Thanks to all of our volunteers and a special shout-out to Sofie Van de kerckhoven for the excellence at intake and sampling! bit.ly/4gV9TLk
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Sleegers Lab @sleegerslab.bsky.social · 02/10/2025
🚨 #PhD opportunity! Sleegers & Rademakers Labs are looking for a PhD candidate to develop biomarkers for neurological disorders by integrating genomics & transcriptomics data🧠🔬 @cmn-vib.bsky.social 📍 Antwerp, Belgium | 💡 Genetics • Bioinformatics • Neuroscience Apply 👉 jobs.vib.be/j/124544/joi...
jobs.vib.be
Joint PhD position on developing genetic risk scores as biomarkers for neurological disorders - VIB
The Rademakers team and the Sleegers team at the VIB-UAntwerp Center for Molecular Neurology, Belgium a
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Fahri Küçükali @maegsul.bsky.social · 02/10/2025
Join us for this great collaborative PhD project! 😊
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cmn-vib.bsky.social @cmn-vib.bsky.social · 25/09/2025
Next up in our #CMNcohorts #CMNconsortia series, we spotlight a collaboration between the @sleegerslab.bsky.social and Dietmar Thal at KU Leuven: a post-mortem brain cohort, now paired with genetic characterization, and transcriptomic profiling underway.
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Jasper Verwilt @verwilt.bsky.social · 10/09/2025
Over the moon to be selected for the Flemish #PhDCup 2025 for my research at @ugent-fge.bsky.social at the OncoRNALab with @jvdesomp.bsky.social and Pieter Mestdagh! @fwovlaanderen.bsky.social
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Sleegers Lab @sleegerslab.bsky.social · 10/09/2025
Our postdoc @verwilt.bsky.social is selected for the @scimingo.bsky.social PhD Cup for his research during his PhD! 💥 Let's see how his findings can impact Alzheimer's Disease 🧠🧬🩸 @fwovlaanderen.bsky.social @ugent-fge.bsky.social @cmn-vib.bsky.social @viblifesciences.bsky.social @uantwerpen.be
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cmn-vib.bsky.social @cmn-vib.bsky.social · 30/06/2025
Big congrats to @verwilt.bsky.social‬ from the @sleegerslab.bsky.social‬ on his FWO fellowship! He’ll be mapping RNA and DNA in blood, CSF, even tear fluid, to develop non-invasive biomarkers for Alzheimer’s using long-read sequencing. tinyurl.com/ym6c8csr
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GWAS Catalog @gwascatalog.bsky.social · 11/06/2025
🚨Interested in which genes are the true effectors behind the scenes of the #gwas results? 🚨 This new publication in Nature Genetics, a collaboration between @broadinstitute.org @ebi.embl.org @opentargets.org focuses on approaches to predicted effector gene reporting tinyurl.com/98yxy4hf (1/3) 👇
tinyurl.com
Realizing the promise of genome-wide association studies for effector gene prediction - Nature Genetics
This Perspective argues that predicting effector genes for complex diseases is a key outcome of genetic association studies where standards are urgently needed to maximize utility, improve interoperab...
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Fahri Küçükali @maegsul.bsky.social · 24/05/2025
Hi #eshg2025! I’ll be giving the final presentation today on our recent work mapping Alzheimer's disease genetic risk to brain cell-type-specific transcript alterations 🧬🧠 Looking forward to it—see you there! 😄
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Reposted by Fahri Küçükali
Sleegers Lab @sleegerslab.bsky.social · 24/05/2025
Ciao Milano! We are happy and excited to be here for #eshg2025 @eshg.bsky.social Come find us during the oral and poster presentations by our team members Fahri Küçükali (@maegsul.bsky.social) & Celeste Laureyssen (@celestelaureyssen.bsky.social) today and tomorrow 🧬 🧠
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Sleegers Lab @sleegerslab.bsky.social · 22/05/2025
Look at us! 🤩 We presented the excuting research going on in our lab at the @uantwerpen.be NeuroDay 2025. So great to with fellow neuroscientist! 🧠
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Sleegers Lab @sleegerslab.bsky.social · 22/05/2025
A new chapter in our lab has begun! Our postdoc @verwilt.bsky.social has received an FWO Junior Fellowship to look for non-invasive extracellular biomarkers for Alzheimer’s disease. Stay tuned for some cool research! @fwovlaanderen.bsky.social
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Jasper Verwilt @verwilt.bsky.social · 22/05/2025
YOU MUST BE KIDDING ME! 🥳 Extremely happy to be selected as a Junior FWO Postdoctoral fellowship! Stay tuned for novel extracellular biomarkers for Alzheimer’s disease! Can’t wait to jump in these three years! 🧠🩸🧬 #fwo #RNA #cfDNA #alzheimers @fwovlaanderen.bsky.social @sleegerslab.bsky.social
fwo.be
Fwo
There were 1038 applications for the junior fellowships and 439 for the senior fellowships. As a result, the success rate this year fell to 16.1% (-1.3%) for junior postdocs and 25.9% (-7.8%) for senior postdocs.
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Fahri Küçükali @maegsul.bsky.social · 30/04/2025
Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing www.nature.com/articles/s41...
nature.com
Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing - Nature Communications
Here the authors identify TNIP1 as a risk factor for a fatal neurodegenerative disorder and discover specific genetic loci associated with the three main subtypes of this disorder. The findings highli...
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Reposted by Fahri Küçükali
Sleegers Lab @sleegerslab.bsky.social · 22/04/2025
Our lab’s recent hackathon ☕🧠💻 was a success: three packed days, one awesome crew, endless ideas. We built fresh neurogenomics tools and leveled-up team vibes 🚀🧬
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Sleegers Lab @sleegerslab.bsky.social · 03/04/2025
🚨 PhD Position Alert! 🚨 We're excited to announce a collaborative PhD opportunity with @uantwerpen.be LEMP, investigating the role of mucin splicing in colorectal cancer. If you're passionate about RNA biology, omics, and translational research, this could be the perfect fit!
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Jordanova lab @jordanovalab.bsky.social · 28/02/2025
Rare, but not alone. Today, we light up for #RareDiseaseDay. We recognize the strength of those living with rare diseases and the science that seeks to understand, diagnose, and treat them. #PatientsFirst 🧬 💙
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Fahri Küçükali @maegsul.bsky.social · 13/02/2025
Exciting news! Our paper on GWAS gene prioritization for Creutzfeldt-Jakob Disease is now published in Brain! 🧠🧬 @brain1878.bsky.social We leverage eQTL and pQTL catalogues to identify prioritized risk genes with potential roles in prion disease. Check it out here: academic.oup.com/brain/advanc...
academic.oup.com
Multiomic analyses direct hypotheses for Creutzfeldt-Jakob disease risk genes
Küçükali & Hill et al. integrate GWAS data with transcriptome and proteome-wide association studies to better understand risk factors for sporadic Creu
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Simon Mead @smead2.bsky.social · 01/02/2025
New paper on risk genes for sporadic CJD academic.oup.com/brain/advanc...
academic.oup.com
Multiomic analyses direct hypotheses for Creutzfeldt-Jakob disease risk genes
Küçükali & Hill et al. integrate GWAS data with transcriptome and proteome-wide association studies to better understand risk factors for sporadic Creu
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Reposted by Fahri Küçükali
Sleegers Lab @sleegerslab.bsky.social · 05/02/2025
Very happy to see our review on Alzheimer's disease rare genetic variants published in @natrevneurol.bsky.social! 🧠🧬 Huge congrats to our PhD student @laradedeyn.bsky.social 🎉👏✨ www.nature.com/articles/s41...
nature.com
The impact of rare genetic variants on Alzheimer disease - Nature Reviews Neurology
In this Review, the authors summarize the genetic and epidemiological characteristics of rare variants associated with Alzheimer disease so far, and explore the insights that these variants have provi...
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Nature Reviews Neurology @natrevneurol.nature.com · 04/02/2025
New online! The impact of rare genetic variants on Alzheimer disease bit.ly/4hntQtT
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Lara De Deyn @laradedeyn.bsky.social · 05/02/2025
🚨 New Review Alert! 🚨 Excited to share our latest in Nature Reviews Neurology! 🧠✨ We explore the impact of rare genetic risk variants on Alzheimer's disease, shedding light on key insights from recent studies. Thank you for this opportunity! #Alzheimers #variants #Review #rarevariant #genetics
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Sleegers Lab @sleegerslab.bsky.social · 31/01/2025
From tears to AD biomarkers! @verwilt.bsky.social recently received a 10.000 euro @uantwerpen.bsky.social BOF KP grant to kickstart our research on the biomarker potential of tear fluid RNA in AD! 🥲🧬
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Nicholas Mancuso @nmancuso.bsky.social · 28/01/2025
Thrilled to see this out! A jax based glm for single cell eqtl mapping! See 👇for details! 🧬
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Dementia Researcher @dementiaresearcher.bsky.social · 24/01/2025
Joint PhD candidate position in the laboratories of Sarah Weckhuysen and Kristel Sleegers at VIB, Antwerp @viblifesciences.bsky.social working on Biomarker Discovery. Closing date: 24th March www.dementiaresearcher.nihr.ac.uk/job/phd-biom...
dementiaresearcher.nihr.ac.uk
PhD: Biomarker discovery in neurological disorders
Joint PhD candidate position in the laboratories of Sarah Weckhuysen and Kristel Sleegers at VIB, Antwerp working on Biomarker Discovery.
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Jasper Verwilt @verwilt.bsky.social · 23/01/2025
🎉 Unique opportunity to join our amazing lab as a Ph.D. student for a novel line of research. Work with cool, cutting-edge technologies to solve fundamental problems in AD and epilepsy.
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Sleegers Lab @sleegerslab.bsky.social · 23/01/2025
💼💥Ph.D. JOB ALERT!!! Together with the lab of Prof. Weckhuysen, we are looking for a motivated Ph.D. student 🧑‍🎓 to explore the wonders of liquid biopsies and help diagnosing Alzheimer's disease and epilepsy patients 🧠🩸
jobs.vib.be
Joint PhD candidate in the laboratories of Sarah Weckhuysen and Kristel Sleegers - VIB
The Weckhuysen team and the Sleegers team at the VIB-UAntwerp Center for Molecular Neuro
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Jean-Charles Lambert @jclambert.bsky.social · 14/01/2025
Urgent - following a withdrawal, we are looking for a research engineer/post-doctoral fellow (contract of at least two years) to take part in the transcriptomics/‘omics’ analyses of our Alzheimer's disease projects. Please do not hesitate to contact me!
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VIB Technologies @vibtechnologies.bsky.social · 09/01/2025
multidisciplinarity ✅ collaboration ✅ inquisitive mindset ✅ All crucial ingredients of the 'techno-scientific ecosystem' we're always on about. A great example of what can be accomplished in such an environment is #scywalker, a scalable analysis workflow for long-read SC transcriptome sequencing 👇
blog.vib.be
“There is more to be discovered, if you develop the right tools”
Discover scywalker, VIB's groundbreaking workflow for long-read single-cell transcriptome sequencing. Uncover new isoforms, streamline massive datasets, and explore diverse applications from neuroscie...
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Kaur Alasoo @kauralasoo.bsky.social · 17/12/2024
A great paper and a great thread! One point that I partcularly liked was this one: "In particular, [GWAS] variants can be trait specific in two ways: they can either affect a trait-specific gene or affect a pleiotropic gene in a context-specific manner."
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Veera Rajagopal @doctorveera.bsky.social · 15/12/2024
Dissecting the mechanism of African ancestries-enriched GBA1 risk variant for Parkinson's disease (PD). A cool example to remind we shouldn't always expect 1-1 relationship between RNA and protein expression. 1/ Álvarez Jerez, Wild Crea, et al. Nat Struct Mol Bio www.nature.com/articles/s41...
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VIB @viblifesciences.bsky.social · 12/12/2024
🧠 New insights into the genetic factors that drive Alzheimer’s disease 👉 Read here: vibbio.tech/4izHlYc 🔬 Study led by Prof. Kristel Sleegers of VIB-UAntwerp Center for Molecular Neurology @uantwerpen.bsky.social @alzassociation.bsky.social
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Jean-Charles Lambert @jclambert.bsky.social · 05/12/2024
Finally out! X‐chromosome-wide association study for Alzheimer. Our new EADB work led by Celine Bellenguez in collaboration with GR@ACE, DEGESCO, EADI, GERAD, DemGene, FinnGen, ADGC and CHARGE. We identified seven X-chromosome-wide significant loci that need further validation. rdcu.be/d2tWv
rdcu.be
X‐chromosome-wide association study for Alzheimer’s disease
Molecular Psychiatry - X‐chromosome-wide association study for Alzheimer’s disease
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Wouter De Coster @wdecoster.bsky.social · 22/11/2024
I have made a new release of kyber, a tool to make a quick sketch of your long-read sequencing data or to compare multiple datasets. It uses a fixed grid of accuracy and read length. Now also supports ubam - feedback appreciated! github.com/wdecoster/ky...
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Eric Fauman (he/him) @ericfauman.bsky.social · 17/11/2024
*taps mic* Is this thing on? Should we try a "Who's that causal gene?" 🧪
MidJourney image of a woman in a yellow dress with yellow fire hair holding a weight
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