Background Accurate identification of truncal mutations, those present in all tumor cells, is essential for understanding tumor evolution and guiding downstream analyses in cancer genomics, including ...

Morlion et al. analyze cell-free RNA in blood plasma from people with and without cancer to identify cancer-specific patterns. Individual patients exhibit unique changes in cell-free RNA, and the numb...

Background: DNA barcoding enables multiplexed identification of biomolecules in pooled sequencing experiments, with broad applications including spatial transcriptomics. Photolithographic synthesis of...

Extracellular vesicles (EVs) have significant potential as therapeutic agents and as sources of diagnostic, predictive, and prognostic nucleic acid biomarkers. However, variability in EV workflows and...

After more than seven years of research, our extracellular RNA quality control (exRNAQC) study has culminated in a scientific publication. This milestone is not just about sharing new findings – it re...

AbstractBackground. In 2009, the Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines established standards for

Clonal hematopoiesis is the expansion of a genetically related population of hematopoietic stem and progenitor cells that disproportionately contribute to blood-cell production.1 Clonal hematopoies...

The authors present a protocol for the self-assembly of single-cell suspensions into spheroids by the liquid overlay method, followed by a modular framework of orthogonal assays to phenotype spheroids...

“If we cut or limit funding for curiosity-driven research, we risk shutting down the pipeline of future innovation,” writes Carole LaBonne of Northwestern.

Rond 400 voor Christus ontwikkelde Hippocrates, de grondlegger van de moderne geneeskunde, zijn leer der humores. Hij stelde dat de gezondheid van de mens af...