Sign in

Marcel Dickmanns | 🌿❄️🔬

@madic.bsky.social
2.6K followers 1.8K following 290 posts

Shooting electrons, ions and photons (mainly) at plants to study cell-cell communication @mpibiochem.bsky.social & @hhu.de

PostsRepliesMedia
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 23h
Thanks comrade! 🫡
000
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 23h
Thank you!!
010
Reposted by Marcel Dickmanns | 🌿❄️🔬
Paul & Virginie - Centriole Lab @centriolelab.bsky.social · 08/10/2026
We are updating our Expansion Microscopy (U-ExM) website with : - Protocols tips to help you get started - Examples of applications across different biological systems. - work in progress - an antibody database 👉 mocel.unige.ch/research-gro...
18655
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 09/10/2026
If you're looking to really get into the weeds of #cryoET in plant tissue 🌿❄️🔬, our detailed protocol is now out in @bio-protocol.bsky.social 🔗 bio-protocol.org/en/bpdetail?...
13012
Reposted by Marcel Dickmanns | 🌿❄️🔬
Diz-Muñoz Lab @diz-lab.bsky.social · 03/10/2026
We built a fully functional LegoAFM for imaging! 🤩... Today presented at #TürenAuf Tag der #SendungMitDerMaus! ... Remember: Always be curious! ⁉️
25816
Reposted by Marcel Dickmanns | 🌿❄️🔬
FocalPlane @focalplane.bsky.social · 24/09/2026
🌱🔬Register now for our plant imaging series! In this webinar, @madic.bsky.social will take us exploring through plant cells using cryo-ET, while @lauracopeland.bsky.social focuses on root-microbial dynamics using FPM and fluorescence microscopy. 🗓️15 October focalplane.biologists.com/2026/09/23/r...
FocalPlane features… quantitative plant imaging across scales
Thursday 15 October, 15:00 BST (UTC+1)
Organised by Alex Johnson and Joe McKenna 
FocalPlane logo

Picture of Marcel Dickmanns (Max Planck Institute of Biochemistry & Heinrich Heine University Düsseldorf)
Exploring the Molecular Landscape within Plant Cells by Cryo-Electron Tomography

Picture of Laura Copeland (University of Strathclyde)
Multimodal Quantitative Fourier Ptychographic Microscopy and Fluorescence Imaging Reveals Stable Bacterial Colonisation Architecture Under Phosphate Limitation

#FocalPlaneFeatures 
focalplane.biologists.com
Cryo-ET segmentation of a plasmodesmata.
1169
Reposted by Marcel Dickmanns | 🌿❄️🔬
Sebastian Samwald (Basti) he/him @samwalds.bsky.social · 23/09/2026
This has originally developed out of a thought along the lines of: "What can you do if you only manage to get weak fluorescence signals?" A short explaining thread 🧵
24324
Reposted by Marcel Dickmanns | 🌿❄️🔬
Kasper van Gelderen @kaspervangelderen.bsky.social · 13/09/2026
The first preprint of my lab has just come out doi.org/10.64898/202... This paper came out at the same day on the sudden passing of Prof. Meng Chen. Without his work, this paper would not have existed. He was an extremely supportive member of the plant photobiology community..
doi.org
87631
Reposted by Marcel Dickmanns | 🌿❄️🔬
Michael Hothorn @structplantbio.bsky.social · 11/09/2026
Nice work by @cellsensing.bsky.social Glycan recognition by a plant damage-sensing immune receptor www.science.org/doi/10.1126/...
science.org
Glycan recognition by a plant damage-sensing immune receptor
Pathogens target and degrade the extracellular matrix surrounding plant cells. A central question is how cell wall-derived damage-associated molecular patterns (DAMPs) are recognized and integrated to...
06734
Reposted by Marcel Dickmanns | 🌿❄️🔬
Caitie McCafferty @computingcaitie.bsky.social · 09/09/2026
I am looking for a lab manager for my group that I will be starting at the @fmiscience.bsky.social in February! We will use in situ structural biology to investigate dynamic ciliary processes. More info here —> bsky.app/profile/comp... #cilia #teamtomo #proteomics #protistsky
34543
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 03/09/2026
Awesome, congrats!!
010
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 25/08/2026
You may find inspiration in this recent thread and discussion: bsky.app/profile/flor...
120
Reposted by Marcel Dickmanns | 🌿❄️🔬
Kedrov Lab @ HHU @kedrov-lab.bsky.social · 23/08/2026
Preprint🚨: Exopolysaccharide export complex PelBC of Pseudomonas aeruginosa attenuates the dynamics of the surrounding outer membrane. Longer in preparation than in actual making. Blame summer time and perfectionism 🫠 A brief tour, to keep the feed alive over the wknd www.biorxiv.org/content/10.6...
2259
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 21/08/2026
it's very much in use still 😅
010
Reposted by Marcel Dickmanns | 🌿❄️🔬
Juan Carlos De la Concepcion @delaconcepcionjc.bsky.social · 05/08/2026
PLEASE SHARE! New job openings in my lab @zmbp-tuebingen.bsky.social. We have a broad interest into the mechanistic basis of how molecular complexes are rewired during cellular development in plants and during invasion by pathogens. 🌱🍄🔬 See details below 👇 #PlantSciJobs
274105
Reposted by Marcel Dickmanns | 🌿❄️🔬
Florent Waltz @florentwaltz.bsky.social · 07/08/2026
We've been seeing a lot of "in situ" lately in titles from fancy journals (not pointing any fingers 👀). I’ve delayed posting this, but as more and more come out, I'm afraid "in situ" is becoming an empty buzzword, much like "near-atomic" was for SPA 🔬 1/n #cryo-ET #cryo-EM #cryoET #cryoEM 🧪
85616
Reposted by Marcel Dickmanns | 🌿❄️🔬
Richard Sever @richardsever.bsky.social · 06/07/2026
“move from preprint to peer-reviewed publication leaves the central claims of most abstracts intact, indicating preprints are a reliable source…papers that were never posted as preprints were retracted at roughly twice the rate of those that were…” www.biorxiv.org/content/10.6...
biorxiv.org
Tracking claim changes from preprint to publication across 72,644 biomedical studies using large language models
Preprints now disseminate a large share of biomedical research before peer review. Because they have not yet passed peer review, some scientists regard preprint claims as unverified or potentially unr...
611158
Reposted by Marcel Dickmanns | 🌿❄️🔬
Max Planck Institute of Biochemistry @mpibiochem.bsky.social · 03/07/2026
#pictureofthemonth: Plant cells use tiny pores called plasmodesmata to talk to each other. The rendering, shows how everything links together. More: www.biochem.mpg.de/baumeister-p... July – Calendar of @mpiforbi.bsky.social and @mpibiochem.bsky.social 📸 by Monika Krause & Marcel Dickmanns
074
Reposted by Marcel Dickmanns | 🌿❄️🔬
Björn Usadel @usadellab.bsky.social · 25/06/2026
1/8 What if the genomic features we associate with fungal pathogens were also used by mutualists? We assembled 41 scale lichen genomes across 11 Peltigera species with 30 chromosome scale and 5 T2T revealing an unexpected genomic toolkit behind lichen symbiosis. doi.org/10.64898/202... #lichen
doi.org
A chromosome-scale super-pangenome of the lichen genus Peltigera reveals genome architecture and expanded interaction repertoires shared across pathogenic and mutualistic fungi
Fungi engage in associations with other organisms across a continuum from pathogenic to mutualistic lifestyles. Hence, they require a compendium of molecular capacities, including partner recognition,...
14630
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 24/06/2026
Congrats, looking forward to what you'll uncover!
000
Reposted by Marcel Dickmanns | 🌿❄️🔬
Caitie McCafferty @computingcaitie.bsky.social · 22/06/2026
Happy to finally share that I will be starting my independent group at the @fmiscience.bsky.social in Feb 2027 in a vibrant new environment. We will use integrative in situ structural cell biology methods to investigate ciliary structure and dynamics in several model (and non-model 👀) systems!!
1215431
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 22/06/2026
Awesome, congrats!!:)
020
Reposted by Marcel Dickmanns | 🌿❄️🔬
Biohub @biohub.org · 04/06/2026
Better vitrification = better cryo-ET. We've opened an RFA for two-year grants to advance vitrification techniques for biological samples—welcoming applications from researchers in heat transfer, cryogenics, and materials science. Apply here: bit.ly/4uip6eJ
04014
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 28/05/2026
This seem to be two separate issues. Tool used vs quality of outcome. I'm sure there were lazy submissions before LLMs - how were those handled?
100
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 21/05/2026
Plants have many complementing MCTP homologs (the reticulon-containing proteins likely shaping desmotubules) so mutants are difficult. Animals only have 2 copies, one of which localizes to axonal ER: elifesciences.org/articles/22904
elifesciences.org
MCTP is an ER-resident calcium sensor that stabilizes synaptic transmission and homeostatic plasticity
MCTP is a novel presynaptic calcium sensor, resident within the endoplasmic reticulum, that is required for normal baseline neurotransmission, short-term synaptic plasticity and presynaptic homeostati...
010
Reposted by Marcel Dickmanns | 🌿❄️🔬
Mauricio Contreras @mpcontreras.bsky.social · 20/05/2026
Check out our latest work! AlphaFold 3 revealed a transient immune receptor complex that eluded biochemical studies for almost a decade 🤯 We describe a conserved structural logic underlying sensor–helper communication in an NLR immune receptor network 🧵👇
19843
Reposted by Marcel Dickmanns | 🌿❄️🔬
Higor Rosa @hvdrosa.bsky.social · 14/05/2026
Thrilled to share the updated video of my paper in Nature with Maciej (under supervision of @simonemattei.bsky.social & @jomaalab.bsky.social) Proud to use Cryo-ET to uncover how hibernation factors are key to translation restart! To model PTMs in situ and render animations fulfilled my PhD dream!🥹🎉
49621
Reposted by Marcel Dickmanns | 🌿❄️🔬
Pingtao Ding (he/him) @dinglab.bsky.social · 19/05/2026
We have an open-rank professorship position open @unileiden.bsky.social Institute of Biology: careers.universiteitleiden.nl/job/Assistan... welcome to apply! due: 7 June
careers.universiteitleiden.nl
Assistant/Associate/Full Professor Plant Molecular (and Cell) Biology
Assistant/Associate/Full Professor Plant Molecular (and Cell) Biology
03756
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 19/05/2026
Thank you so much, also to the PD community as a whole, for the warm welcome.
020
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 19/05/2026
Thanks a lot!😁
010
Reposted by Marcel Dickmanns | 🌿❄️🔬
Nature Plants @natplants.nature.com · 18/05/2026
New OA Article: "In situ architecture of plasmodesmata in Physcomitrium resolved by cryo-electron tomography" rdcu.be/fjjiK Plasmodesmata are gated by cell wall remodelling; helical protein assemblies scaffold internal membranes; implications for molecular filtering.
02112
Reposted by Marcel Dickmanns | 🌿❄️🔬
Jonathan Kaufman @jggkaufman.bsky.social · 18/05/2026
It's finally out! Molecular architecture of mammalian AP3:ARF1 carriers - a mechanism for lysosomal membrane protein trafficking - from a combination of #biochemistry, #cryoET and #cellbiology 📝 Paper: www.science.org/doi/10.1126/... 🧵 Thread: subsequently #teamtomo #membranetrafficking
24620
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 19/05/2026
desmotubule is 10nm outer diameter, so barely any lumen after subtracting membranes
310
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 17/05/2026
Fig.2 here nicely illustrates the cell wall formation (PM in magenta) around the ER (green) in the center of a dividing cell. www.science.org/doi/10.1126/...
science.org
Plant plasmodesmata bridges form through ER-dependent incomplete cytokinesis
Diverging from conventional cell division models, plant cells undergo incomplete division to generate plasmodesmata communication bridges between daughter cells. Although fundamental for plant multice...
010
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 17/05/2026
Thanks for the paper! So axon ER is 3x wider than desmotubules and has mobile lumen. As to why ER-as-scaffold in PD: it is inherited developmentaly. ER is trapped in forming cell walls during cytokinesis, later becoming the desmotubule in PD of the mature wall used to organize PD protein machinery.
510
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 16/05/2026
Thanks Ralf! Physco turned out to be a good cryoET system:)
030
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 16/05/2026
In that model making it narrow could be advantageous - maximizing the surrounding transport space. Don't know about axons but could it also be to organize signaling machinery?
210
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 16/05/2026
Thanks Cahir and great point! As far as we know the desmotubule is more of a scaffold than a pipe. It stabilizes PD during cell division and organizes protein machinery like the coatings resolved here. The main route is thought to be the cytosol-filled sleeve between it and the PM.
100
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 16/05/2026
Thanks a lot JC!
000
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 15/05/2026
Thanks a lot Kasper!
020
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 15/05/2026
Regarding calreticulin, we do observe small protein densities clustering in the ER lumen near PD apertures but these features are too small and irregular to assign to specific proteins currently.
010
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 15/05/2026
it gets crowded within the pores and we cannot exclude non-filamentous, low-copy, and/or transient actin in the cytosolic sleeve.
110
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 15/05/2026
Great question, thanks! F-actin is easy to spot in tomograms and we do not see it at PD. We also tested whether actin could account for the desmotubule coat, but it does not fit the resolved geometry whereas MCTPs are a very good fit. That said, ...
210
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 15/05/2026
Thank you Mary!:)
030
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 15/05/2026
Thank you Alexej!!:)
020
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 14/05/2026
My blind guess is TFs need disordered parts to sample DNA efficiently. You could try predict in presence of the corresponding DNA motif using AF3 and see if that produces more secondary structure
100
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 14/05/2026
Thanks to very helpful reviewer comments we added a few additional experiments, strengthening the key claims. Also extended the discussion from the preprint. Very grateful for the constructive feedback & editorial process, and for the amazing team of co-authors. This was fun!
090
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 14/05/2026
It's out! 🥳 In situ architecture of #plasmodesmata - plant cytoplasmic bridges - by #cryoET. 📝 Paper: www.nature.com/articles/s41... 🧵 Thread: bsky.app/profile/madi... #teamtomo #proteomics #AlphaFold
nature.com
In situ architecture of plasmodesmata in Physcomitrium patens resolved by cryo-electron tomography - Nature Plants
Using cryo-electron tomography, the authors reveal how plasmodesmata (plant cytoplasmic bridges) are gated by cell wall remodelling and how helical protein assemblies scaffold internal membranes, with...
915658
Reposted by Marcel Dickmanns | 🌿❄️🔬
Dimitry Tegunov @dtegunov.bsky.social · 03/05/2026
We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:
6313118
Reposted by Marcel Dickmanns | 🌿❄️🔬
Gregor Weiss @weiss-lab.bsky.social · 22/04/2026
New preprint 🚀 ❄️ We developed Autogrid-compatible HPF planchettes that enable direct freezing of clipped EM grids and streamline integration with cryo-FIB workflows ✔️ improved grid stability ✔️ reduced handling ✔️ robust vitrification (🦠 🧫 🧠) A step toward routine HPF for complex samples #teamtomo
69030