An updated phylogeny of bats is presented, based on new genome assemblies and many ancient fossils and including all known bat families.

Nature Reviews Genetics, Published online: 11 September 2026; doi:10.1038/s41576-026-01010-9Advances in genome-wide selection scans and ancient DNA have greatly expanded our ability to study human evolution. This Review discusses the conceptual and statistical challenges in identifying and interpreting selection signals, and how recent approaches are reshaping our understanding of human evolution over the past 10,000 years.

The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely unknown. By using live imaging, we reveal that the ...

Objects found in a cave in southwestern China suggest that these enigmatic ancient humans were accomplished hunters.

GPN-Star, a genomic language model with a phylogeny-aware architecture for whole-genome alignment data, is shown to be a scalable and flexible tool for genetic variant effect prediction across species...

AI model AlphaGenome forecasts the consequences of altering every single DNA letter in the human genome.

The peopling of Remote Oceania involved some of humanity’s greatest expansions into the open ocean. Ancient DNA spanning the last 3,000 years from the Solomon Islands, Vanuatu, Fiji, and Tonga reveals...

Genotype imputation enables accurate detection of Neanderthal and Denisovan ancestry in low-coverage ancient genomes and allows the identification of introgressed haplotypes as well as candidate genes...

Newly recovered sheeppox sequences reveal when and how the virus emerged

The transition from hunter-gatherer to agricultural lifestyles is one of the landmarks in the history of human societies, but its phenotypic and immediate molecular consequences remain poorly understo...

By combining repository metadata, genotype-inferred ancestry, and manual curation of publications, Gallego Romero et al. demonstrate that public RNA-seq datasets are dominated by samples from high-inc...

and some very useful numbers about human genomes to get you started!

Battling darkness and cold, researchers on a drifting laboratory will probe the biology of the Arctic Ocean

Ancient DNA can be preserved on materials from archaeological floor deposits such as bones, sediments and artifacts. Here, the authors investigate whether Palaeolithic wall art can preserve human DNA ...

Genetic introgression from Neanderthals and Denisovans shaped modern human genomes; however, introgressed structural variants (SVs ≥ 50 base pairs) remain challenging to discover. We integrated high-q...

AbstractMotivation. Identifying sequence constraint across long evolutionary distances is a powerful method for the discovery of functional genomic sequenc

Mutational Scanning Symposium 2026, 25-27 March, Melbourne

The phenotypic effects of germline variants are often mediated through gene regulation. Expression quantitative trait loci (eQTLs) are genetic variants associated with changes in gene expression. Understanding how eQTLs vary across populations is essential for characterising the genetic and regulatory drivers of trait diversity. Meta-analysing eQTL studies from multiple populations enables more robust detection of eQTLs and can reveal regulatory mechanisms shaped by population-specific environmental or ancestry-related factors. However, across the multi-ancestry eQTL literature, a wide range of methods have been used to quantify eQTL portability across ancestry groups. Because different studies employ different portability metrics, it is challenging to form a coherent view of the regulatory landscape across populations. In this work, we analyse eQTL summary statistics from ten datasets matched on tissue type and sequencing technology. We compare portability metrics used previously and show that they can yield markedly different patterns of apparent regulatory conservation or divergence. We then examine the statistical determinants of portability across metrics and demonstrate that sample size, minor allele frequency, and linkage disequilibrium are major drivers of the observed differences in eQTL portability across studies. These findings highlight that differences in statistical power stemming from factors such as population size and allele frequency must be accounted for when evaluating eQTL portability. To address this issue, we introduce a new approach designed to correct for these factors when calling eQTL portability. Finally, we show that empirical Bayes multivariate adaptive shrinkage provides a powerful framework for meta-analysing multiple eQTL studies, with the ability to pool signals across populations to produce more robust effect-size estimates within each population. ### Competing Interest Statement The authors have declared no competing interest. National Health and Medical Research Council, https://ror.org/011kf5r70, Ideas Grant 2020501, Investigator Grant 1195595

Abstract - Population and medical genetics can provide valuable information about human history and health. However, research involving Indigenous and vulnerable communities often raises ethical issue...

dplyr but make it bussin fr fr no cap. Contribute to hadley/genzplyr development by creating an account on GitHub.

Yang et al. study Denisovan ancestry in ancient and present-day humans. In contrast to other East Asians, genomic comparisons suggest that the Jomon derived most of their ancestry from a deep lineage ...

The geom you always wished for adding cats to ggplot2 - R-CoderDotCom/ggcats