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Lee Zamparo

@lzamparo.bsky.social
1.1K followers 631 following 1.8K posts

Interested in ML, comp bio, immunology, and just about anything one hop away.

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Lee Zamparo @lzamparo.bsky.social · 23/09/2026
Spending more and more time lately on data synthesis. My current mood: it's both way more interesting than I initially thought, but also way more vexing than I initially thought.
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Lee Zamparo @lzamparo.bsky.social · 27/08/2026
Okay, I appreciate that HuggingFace wants to put a happier face on robotics, but it's a bit off brand, no? www.axios.com/2026/08/27/hugging-fa…
axios.com
www.axios.com
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Lee Zamparo @lzamparo.bsky.social · 14/08/2026
The province is legally able to pursue terrible policy, even if it suspects that it's bad policy, as long as it also expresses a public hope that it is not.
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Eugene Vinitsky 🍒 @eugenevinitsky.bsky.social · 12/08/2026
For the past six months @mariaa.bsky.social and I have been working on creating an improved research experience on atproto. It's now live! Check out: lea.ac
leaflet.pub
Lea: research-oriented social media
Introducing a beta-version of our new research-focused social media platform
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old roadside pics @roadside.xor.blue · 11/08/2026
the ferm, kenoza lake, new york, 1976
the ferm, kenoza lake, new york, 1976
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Lee Zamparo @lzamparo.bsky.social · 11/08/2026
"Hydro corridors for kilometers in every direction" eh? I must have missed the hydro corridor running east west through the city so people can get to where they want to go. Also the corridor(s) running north south to where people work, study, shop. Do people genuinely believe this nonsense?
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Lee Zamparo @lzamparo.bsky.social · 11/08/2026
I believe the removal promise, but not the "build something else" promise. Pass.
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Lee Zamparo @lzamparo.bsky.social · 10/08/2026
Looks like a huge joint effort that will have a "rising tide" effect on so many research questions. Bravo to everyone involved!
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Quaid Morris @quaidmorris.bsky.social · 07/08/2026
Excited to share the results of the Codebook Project, an international effort to identify accurate DNA-binding motifs and genomic binding loci for >300 uncharacterized human transcription factors (TFs) www.nature.com/articles/s41...
nature.com
An expanded codebook of human transcription factor DNA-binding specificity - Nature
Results from a panel of assays that analyse different aspects of DNA sequence specificity reveal more than 100 new motifs to aid the characterization of putative human transcription factors.
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Lee Zamparo @lzamparo.bsky.social · 06/08/2026
Finally!
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Lee Zamparo @lzamparo.bsky.social · 05/08/2026
Worm ppl have had this for years, and when I first found out about that it blew my mind. This is more astounding still
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Henry Yuen @henryyuen.bsky.social · 01/08/2026
Some initial thoughts, and a complicated mix of feelings. Wow. I mean, Erdos problems are cool (I genuinely mean that), I didn't know about the Jacobian conjecture before it got disproved. But this newest batch from OpenAI hits home in a way the previous announcements did not.
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Jay Shendure @jshendure.bsky.social · 30/07/2026
New preprint from Shendure Lab on Locus-Scale aka Long-@$$ MPRAs led by the amazing Abby McGee & @carinabiar.bsky.social Most MPRAs test ~300 bp fragments next to a promoter. But real enhancers are bigger, act combinatorially and from a distance. 1/n www.biorxiv.org/content/10.6...
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Lee Zamparo @lzamparo.bsky.social · 24/07/2026
great name, great topic for a workshop
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Su-In Lee @suinlee.bsky.social · 24/07/2026
Grateful to be working with Maria Brbić, Peter Koo @pkoo562.bsky.social, and Bianca Dumitrascu @bimidu.bsky.social on this exciting NeurIPS workshop, together with our incredible student organizers: Siba Smarak Panigrahi, Masayuki Nagai, Özgür Yılmaz Beker, and Soham Gadgil @sohamgadgil.bsky.social.
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Boo!-per Lund @cooperlund.online · 24/07/2026
You ever think about how all this is happening after Orban lost in Hungary
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Emily Atkin @emorwee.bsky.social · 20/07/2026
This. This is the correct, science-backed, responsible framing. Wish more news outlets did it like the CBC.
cbc.ca
'Just stop burning fossil fuels.' Scientists stress that our smoky skies only have one true fix | CBC News
Smoky skies in Toronto have led to new scrutiny of government efforts to fight fires and manage forests. But scientists say the realistic way to tackle the smoke is fighting climate change itself.
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Jonas Nahm @jonasnahm.com · 21/07/2026
1/ Trump signed 50% tariffs on Canada today under Section 338 of the Tariff Act of 1930. Worth walking through the legal mechanics, the USMCA leverage play behind it, and what it costs.
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Lee Zamparo @lzamparo.bsky.social · 19/07/2026
As a non-profit org, I'm sure this means huge investments incoming for grass roots football for the host nations especially, right? Right?
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Lee Zamparo @lzamparo.bsky.social · 16/07/2026
Mickey Sandwich
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Lee Zamparo @lzamparo.bsky.social · 15/07/2026
"Special circumstances" ? The legislature only sat for ~65 days this year (the least since reliable records are available). Peel isn't that far away. Just go home. Same ppl who tell you school boards are irresponsible, who suggest insane tunnels + convention centres nobody needs, a jet for DF.
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ICML Conference @icmlconf.bsky.social · 10/07/2026
We appreciate the love ❤️ But limited engagement and few followers on Bsky makes some (not us!) question whether it's worth it Be sure to follow (and share with your ML friends!) if you want to see more updates from ICML!
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Lee Zamparo @lzamparo.bsky.social · 10/07/2026
I would have said "Comte Figure-de-Poubelle", and "Conte Figura-di-Bidone". I can post this because BlueSky is a pedant's dreamland
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John Timmer @jtimmer.bsky.social · 06/07/2026
Just a reminder that there's only about a week left to leave comments on the OMB proposal that will cripple federally funded research. Here's my attempt to convince you that you should, along with info on how to do so effectively.
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Eugene Vinitsky 🍒 @eugenevinitsky.bsky.social · 09/07/2026
I will literally follow any and all ML PhD students on this website, where you at
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Corey Rayburn Yung @coreyryung.bsky.social · 06/07/2026
All of these can be true at the same time: 1) The suspension reversal was corrupt 2) No FIFA rules were violated (Art 27) 3) Art 27 is ridiculous 4) This is not nearly FIFA's most corrupt action 5) FIFA's history of corruption doesn't justify this corruption 6) The red card by VAR was BS
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thecolorfulkit.com @thecolorfulkit.com · 04/07/2026
Mood
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Your Local Epidemiologist @ylepidemiologist.bsky.social · 02/07/2026
4/ Remember that flu vaccine that RFK Jr.’s FDA said they wouldn’t review and then, after immense backlash, reviewed again? Well, we got exciting news: An FDA advisory panel voted 9-0 to back Moderna's mRNA flu vaccine, mFlusiva.
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Lee Zamparo @lzamparo.bsky.social · 03/07/2026
Dubious. Leao had himself an insane game, created a ton of danger, hit the crossbar with what would have been goal of the tournament, and he's trashed on this garbage board?
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Armine Yalnizyan @armineyalnizyan.bsky.social · 26/06/2026
Succinct, elegant piece by @danyaalraza.com and Braden Manns on what "dual practice" is and does. Where's the federal Minister of Health? This is a clear violation of the Canada Health Act. Don't look away. #Never51st isn't only about fighting against Trump's chaos. It's about fighting *for* us.
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Prasad Jallepalli, MD, PhD @prasad.bsky.social · 24/06/2026
Age-standardized cancer death rates fell from over 150 per 100,000 Americans in 1990 to less than 100 as of 2022. A one-third drop in just over 10 years. ourworldindata.org/grapher/canc...
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Lee Zamparo @lzamparo.bsky.social · 24/06/2026
The Dufferin bus lanes are an unjustly delayed triumph. Sufferin no more!
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Michael L. Barnett @mlbarnett.bsky.social · 23/06/2026
holy sh*t, STAT is not messing around "STAT does not know who the patient is. But given the patient demographics and the unusual nature of the application, STAT asked the White House whether the patient was President Trump" www.statnews.com/2026/06/23/e...
statnews.com
Eli Lilly gave extraordinary obesity drug access to a 79-year-old patient. Who was it?
Exclusive: STAT has learned that Eli Lilly and the FDA allowed a 79-year-old to gain extraordinary access to an experimental obesity drug through the agency’s “compassionate use” program.
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Lee Zamparo @lzamparo.bsky.social · 22/06/2026
Why is it that some days, you have zero useful ideas, and other days you get multiple really solid research ideas? What the hell, brain, pace yourself.
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Naomi Saphra @nsaphra.bsky.social · 15/06/2026
We don’t always know what problems are hard for LLMs. So devs evaluate on tasks HUMANS find hard or on broad benchmarks. What if we could instead anticipate which scenarios a model will fail on—all without evaluating specific input examples? 🧵NEW PAPER by @jenniferlumeng.bsky.social
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Lee Zamparo @lzamparo.bsky.social · 12/06/2026
Wooooooooooooooooooooooooo!
static.klipy.com
Ric Flair's Iconic Woo! Meme
Alt: Ric Flair's Iconic Woo! Meme
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Lee Zamparo @lzamparo.bsky.social · 12/06/2026
He sure as hell does!
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Stella Biderman @stellaathena.bsky.social · 10/06/2026
In film, "we'll fix it in post" is what you say when something went wrong on set and you don't want to redo it. AI research has made it our entire methodology: train the model, then patch whatever comes out. Our new ICML oral argues this can't be the basis of a science of AI. 🧵
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old roadside pics @roadside.xor.blue · 09/06/2026
big fish supper club, bena, minnesota, 1980
big fish supper club, bena, minnesota, 1980
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Alex Baumhardt @alexbaumhardt.bsky.social · 07/06/2026
Anthropoic founder: “How will we ensure the gains of AI are shared globally? We do not have a mechanism for this.” @bcmerchant.bsky.social: “They're called taxes. And just because AI companies don't really like that idea, they don't like the concept of being taxed, doesn't mean they don't exist.”
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Miser @misernyc.bsky.social · 07/06/2026
The pedestrianization of Broadway through the heart of Manhattan just expanded, and it's glorious:
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Lee Zamparo @lzamparo.bsky.social · 05/06/2026
Me getting an email from TMLR
static.klipy.com
Just When I Thought I Was Out They Pull Me Back In
Alt: Al Pacino as Michael Corleone from The Godfather Part III, saying "Just When I Thought I Was Out They Pull Me Back In"
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#SingleCell preprints @prepub-singlecell.bsky.social · 03/06/2026
A multimodal perturbation atlas defines the phenotypic resolution of cellular morphology. #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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Dr. Lucky Tran @luckytran.com · 02/06/2026
Incredible! Scientists receive a rare standing ovation after announcing that a new treatment can double the survival time for pancreatic cancer, the deadliest cancer which was once considered “undruggable.” When we fund and support science, we can achieve anything! (Video: Dr. Wish Dhillon)
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Greg Sargent @gregsargent.bsky.social · 01/06/2026
"One thing that actually propelled actual US greatness after World War II was tying large scientific investments to a non-partisan, merit-based process. But that is not the way of Trump, who wants to extend tools of control and retribution over science." Trump is wrecking everything. Illuminating:
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Canadian Paintings @canadianpaintings.bsky.social · 26/05/2026
Rec League Nelson White ~ Mi'kmaq c. 2026
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Robert "The Bobby Yaga" McNees @mcnees.bsky.social · 26/05/2026
Sonny Rollins was the last surviving musician from Art Kane’s famous photo “A Great Day In Harlem.” Image: Art Kane
A black and white photograph showing dozens of jazz musicians arranged on the steps in front of a building in Harlem. The photgrapher was Art Kane.
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Alex Bozikovic @alexbozikovic.bsky.social · 26/05/2026
The old centre was 568,000 ft.². The new one is 280,000 ft.² (The province is floating a misleading number of 400k but that reflects a math error, plus 120k is a parking garage.) The old building’s exhibition space was 134k. The new one has 120k. Not bigger. Smaller.
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Shicheng Guo @shihcheng.bsky.social · 25/05/2026
Discover BEstimate: a tool streamlining CRISPR base editing with precise gRNA design, targeting site analysis, and off-target predictions! 🧬✨ PMID:42045938, Genome Biol 2026 @OTSociety @NAR_Open doi.org/10.1186/s13059-026-04077-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
doi.org
BEstimate: a computational tool for the design and interpretation of CRISPR base editing experiments | Genome Biology | Springer Nature Link
CRISPR base editors enable scalable targeted DNA mutagenesis and are a powerful tool for analysing the function of variants of uncertain significance and d
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Shawn Micallef @shawnmicallef.bsky.social · 23/05/2026
Doug Ford balked on his home building promises / & reforms by giving in to his nimby base, people who are also afraid of people without homes. Good luck Ontario.
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