Members must go beyond reinstating US government research spending and re-establish decentralized governance at the National Institutes of Health and other agencies.

Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increa...

Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increa...

Brunner et al. report that malate-aspartate shuttle engagement is cell-state dependent and can be modulated by the availability of the amino acid aspartate. In differentiated cells, malate-aspartate s...

Nature Metabolism - Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a...