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Zeshi Li (Jack)

@lizeshi.bsky.social
247 followers 477 following 31 posts

Assistant Professor, Chemical Biology and Drug Discovery, Utrecht U. PhD G.-J.Boons Lab; Post-doc C.Joo Lab TUDelft. www.uu.nl/medewerkers/ZLi2

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Zeshi Li (Jack) @lizeshi.bsky.social · 15/08/2026
Dear Bluesky community, does anyone have any insight into what’s going on at the @idtdna.bsky.social plant in Belgium? Many of our oligo orders have been significantly delayed, with several repeatedly failing synthesis/QC cycles. Some colleagues have experienced similar issues.
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Zeshi Li (Jack) @lizeshi.bsky.social · 17/06/2026
Excited to share the very first #preprint since I started my lab at @utrechtuniversity.bsky.social We explored the area of small molecule- #RNA interaction, and present SOLiD-MaP: a #photoproximity labeling platform for mapping small molecule binding site on RNA. www.biorxiv.org/content/10.6...
biorxiv.org
SOLiD-MaP: A Photoproximity Labeling Platform for Small Molecule Binding Site Mapping on RNA
RNA-targeting small molecules are emerging as promising therapeutic modalities, but their development requires methods that define binding sites and evaluate RNA target selectivity. Existing approache...
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Zeshi Li (Jack) @lizeshi.bsky.social · 13/04/2026
We have a 3-year post-doc position open. Apply now and join BioBeyond_NL to power up mass spec studies with new chemical biology tools! www.uu.nl/en/organisat...
uu.nl
Postdoc Position in Chemical Biology
Join us to design cutting-edge chemical biology tools and reveal molecular mechanisms in complex biological systems.
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Reposted by Zeshi Li (Jack)
Iain Wilson @iainwilsonwien.bsky.social · 16/02/2026
RIP: Professor Dr. Johannes Frederik Gerardus (Hans) Vliegenthart (April 7, 1936 – February 12, 2026) A leading figure in structural Glycobiology. www.uu.nl/en/news/in-m...
uu.nl
In memoriam: Hans Vliegenthart
In memoriam: prof. dr. Hans Vliegenthart (April 7, 1936 – February 12, 2026)
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Reposted by Zeshi Li (Jack)
Ryan Flynn @raflynn5.bsky.social · 28/01/2026
Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
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Zeshi Li (Jack) @lizeshi.bsky.social · 18/12/2025
How are RNAs presented on the cell surface without any transmembrane domains? In our paper published at Molecular Cell @cp-molcell.bsky.social, we provide mechanistic insights into this pressing question. They form ternary complexes with RNA-binding proteins and heparan sulfate proteoglycans.
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Reposted by Zeshi Li (Jack)
Nathanael B. Kegel @nathanaelbkegel.bsky.social · 18/11/2025
Now finally peer-reviewed and published in @springernature.com Experimental & Molecular Medicine (EMM)🥳: www.nature.com/articles/s12... Our story was published back-to-back with the intriguing paper by Kim et al.: www.nature.com/articles/s12...
nature.com
Proteins are a source of glycans found in preparations of glycoRNA - Experimental & Molecular Medicine
Glycosylation, a process where sugars attach to molecules, is known to modify proteins and lipids. Recently, researchers discovered that RNA can also be glycosylated. This study explores the presence ...
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Zeshi Li (Jack) @lizeshi.bsky.social · 17/11/2025
Had the pleasure to learn about this cool platform over a Friday afternoon seminar during Matt’s visit at UU.
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Reposted by Zeshi Li (Jack)
U Utrecht-CBDD @uu-cbdd.bsky.social · 15/11/2025
New @angewandtechemie.bsky.social paper jointly supervised by Zeshi Li @lizeshi.bsky.social and Geert-Jan Boons describes the chemoenzymatic synthesis of O-acetylated GD3 as intact glycolipids, and the use there of to study virus binding in cellular context. onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Chemoenzymatically Synthesized O‐Acetylated GD3 Gangliosides to Examine Viral Receptor Specificities in a Cellular Context
7-O-, 9-O-, and 7,9-di-O-acetylated GD3 gangliosides can be prepared by chemical assembly of a tetrasaccharide as α-glycosyl fluoride that is coupled to sphingosine using a glycosynthase, followed by...
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Zeshi Li (Jack) @lizeshi.bsky.social · 15/11/2025
#glycotime We hope our b2b publications serve as a heads-up for the #glycoRNA community, and drive the field forward constructively. Links👇 Kim et al. rdcu.be/eP4GQ @nathanaelbkegel.bsky.social Kegel et al. nature.com/articles/s12276-025-01575-1 (Stefan Bauer lab)
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Reposted by Zeshi Li (Jack)
Friedrich Förster @fridof.bsky.social · 04/11/2025
Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that! www.uu.nl/en/news/33-m...
uu.nl
33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
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Reposted by Zeshi Li (Jack)
Daniel Hurdiss @danielhurdiss.bsky.social · 03/11/2025
Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬 Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠 www.uu.nl/en/news/33-m...
uu.nl
33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
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Zeshi Li (Jack) @lizeshi.bsky.social · 03/11/2025
Deeply honored to be a co-applicant of #BioBeyond_NL. The team will develop enabling #MassSpec based technologies to advance (glyco)proteomics, glycomics and spatial omics. Stay tuned for PhD/post-doc openings in the near future! www.nwo.nl/en/news/nati...
nwo.nl
National Roadmap: NWO invests 197 million euro in eleven Large-Scale Research Infrastructures | NWO
Eleven consortia from various scientific disciplines are set to launch projects of great value to science. But also to the economic and social prosperity of the Netherlands. For example, a consortium led by TU Delft will start work on a detailed virtual model of the Dutch energy system. In another project, a consortium of UMC Utrecht is developing an MRI scanner that can scan people in motion.
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Reposted by Zeshi Li (Jack)
U Utrecht-CBDD @uu-cbdd.bsky.social · 03/11/2025
Congratulations to CBDD researchers, Geert-Jan Boons and Zeshi Li @lizeshi.bsky.social, and members of #BioBeyond_NL, a consortium co-led by Maastricht, Utrecht, Radboud University and LUMC researchers to advance (glyco)proteomics, glycomics and spatial omics. Read more👇 www.nwo.nl/en/news/nati...
nwo.nl
National Roadmap: NWO invests 197 million euro in eleven Large-Scale Research Infrastructures | NWO
Eleven consortia from various scientific disciplines are set to launch projects of great value to science. But also to the economic and social prosperity of the Netherlands. For example, a consortium led by TU Delft will start work on a detailed virtual model of the Dutch energy system. In another project, a consortium of UMC Utrecht is developing an MRI scanner that can scan people in motion.
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Reposted by Zeshi Li (Jack)
Ryan Flynn @raflynn5.bsky.social · 11/04/2025
Advancing #glycoRNA imaging with FRET-based detection and expanding the scope of their presentation to extracellular vesicles - interestingly high levels of sialoglycoRNAs on blood EVs can be predictive of having cancer @naturecomms.bsky.social www.nature.com/articles/s41...
nature.com
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Reposted by Zeshi Li (Jack)
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 11/04/2025
SCAM ALERT. This is a fake conference that ripped off my and other people’s names to trick people into registering. There is no such conference that I or the others shown were invited or agreed to. We are working to try to get this fraud taken down from the web. chemsymposia.com
chemsymposia.com
Join Chemsymposia 2026: Research & Innovation | ChemSymposia 2026
Join us at Chemsymposia 2026 to discover groundbreaking research in physics applications. Connect with experts, engage in insightful discussions, and explore our venue, registration details, and speak...
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Reposted by Zeshi Li (Jack)
Jordan Meier @doc-jlmeier.bsky.social · 30/03/2025
Question for glycoRNA proponents: What specific evidence would convince you that these signals are protein contaminants rather than modified RNA? Since so much evidence depends on extraction & analysis of pure RNase-sensitive glycoRNA, this seems like a problem. Worth reading the whole exchange ⬇️
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Zeshi Li (Jack) @lizeshi.bsky.social · 28/03/2025
Here is an updated version of a preprint posted in 2024: It describes a non-RNA glycoconjugate persisted throughout RNA sample processing, with similar electrophoretic properties and enzymatic reactivity as glycoRNA. It confounds gel-/blot-based glycoRNA assays. www.biorxiv.org/content/10.1...
biorxiv.org
RNA-Associated Glycoconjugates Highlight Potential Ambiguities in glycoRNA Analysis
A recent ground-breaking study suggested that small RNA from mammalian cells can undergo N-glycan modifications (termed glycoRNA) 1. The discovery relied upon a metabolic glycan labeling strategy in c...
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Reposted by Zeshi Li (Jack)
Iris @irismarchal.bsky.social · 18/03/2025
Nanopore technology might be able to sequence proteins soon! Read about the road ahead in this exciting Perspective rdcu.be/edWPi in @naturebiotech.bsky.social
rdcu.be
Toward single-molecule protein sequencing using nanopores
Nature Biotechnology - Maglia and colleagues discuss advances in nanopore technology en route to single-molecule protein sequencing
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Reposted by Zeshi Li (Jack)
Protea Glycosciences @proteaglyco.bsky.social · 24/03/2025
We're just completing an R&D sprint to identify an LC additive that increases our glycan identifications 3x and enhances glycan charge states by up to 45%🚀. It's too early to publicly disclose its identity, but here's a results preview. Interested? Message or email us, we'd love to collaborate.
Manuscript figure describing our method for evaluating mobile phase additives for enhanced negative mode LC-MS of glycans. The results show different O-glycan compositions having up to 40% higher charge states.
Interested in how our platform can help you discover more from your samples? Email us at info@proteaglyco.com to collaborate.
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Reposted by Zeshi Li (Jack)
Suyang Zhang @suyangzhang.bsky.social · 24/03/2025
Excited to share our new preprint on co-transcriptional splicing! U1 snRNP is recruited to RNA polymerase II through multiple interaction sites, with elongation factor SPT6 binding directly to the U1 snRNP protein. www.biorxiv.org/content/10.1... #cryoEM #transcription #splicing
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Zeshi Li (Jack) @lizeshi.bsky.social · 24/03/2025
Excited to share an update on heparan sulfate (HS)-associated cell-surface RNA (hepRNA): www.biorxiv.org/content/10.1...
biorxiv.org
Cell-Surface RNA Forms Ternary Complex with RNA-Binding Proteins and Heparan Sulfate to Recruit Immune Receptors
Recent discoveries have shown the presence of RNA molecules on the cell surface, defying the traditional view that RNA only functions intracellularly. However, it is not well understood how cell-surfa...
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Reposted by Zeshi Li (Jack)
bioRxivpreprint @biorxivpreprint.bsky.social · 01/03/2025
Transcriptome-wide Identification of GlycoRNAs by Clier-seq Pipeline www.biorxiv.org/content/10.1101/202…
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Reposted by Zeshi Li (Jack)
bioRxivpreprint @biorxivpreprint.bsky.social · 18/03/2025
Proteins are a source of glycans found in preparations of glycoRNA www.biorxiv.org/content/10.1101/202…
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Reposted by Zeshi Li (Jack)
U Utrecht-CBDD @uu-cbdd.bsky.social · 18/12/2024
Hello, Bluesky community! Let our first post be a good news: CBDD researchers Geert-Jan Boons and Rob de Vries (@rpdevrieslab.bsky.social), together with researchers in ErasmusMC Rotterdam, were awarded an #ENW-XL from the Dutch Research Council. Stay tuned for #phd/#post-doc openings! #glycotime
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