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U Utrecht-CBDD

@uu-cbdd.bsky.social
215 followers 376 following 7 posts

Division Chemical Biology and Drug Discovery, Utrecht Institute of Pharmaceutical Sciences (UIPS). Glycoscience, virology, immunology, MedChem, RNA, etc. www.uu.nl/en/research/chemical-biol…

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Reposted by U Utrecht-CBDD
Zeshi Li (Jack) @lizeshi.bsky.social · 18/12/2025
How are RNAs presented on the cell surface without any transmembrane domains? In our paper published at Molecular Cell @cp-molcell.bsky.social, we provide mechanistic insights into this pressing question. They form ternary complexes with RNA-binding proteins and heparan sulfate proteoglycans.
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U Utrecht-CBDD @uu-cbdd.bsky.social · 15/11/2025
New @angewandtechemie.bsky.social paper jointly supervised by Zeshi Li @lizeshi.bsky.social and Geert-Jan Boons describes the chemoenzymatic synthesis of O-acetylated GD3 as intact glycolipids, and the use there of to study virus binding in cellular context. onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Chemoenzymatically Synthesized O‐Acetylated GD3 Gangliosides to Examine Viral Receptor Specificities in a Cellular Context
7-O-, 9-O-, and 7,9-di-O-acetylated GD3 gangliosides can be prepared by chemical assembly of a tetrasaccharide as α-glycosyl fluoride that is coupled to sphingosine using a glycosynthase, followed by...
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U Utrecht-CBDD @uu-cbdd.bsky.social · 03/11/2025
Congratulations to CBDD researchers, Geert-Jan Boons and Zeshi Li @lizeshi.bsky.social, and members of #BioBeyond_NL, a consortium co-led by Maastricht, Utrecht, Radboud University and LUMC researchers to advance (glyco)proteomics, glycomics and spatial omics. Read more👇 www.nwo.nl/en/news/nati...
nwo.nl
National Roadmap: NWO invests 197 million euro in eleven Large-Scale Research Infrastructures | NWO
Eleven consortia from various scientific disciplines are set to launch projects of great value to science. But also to the economic and social prosperity of the Netherlands. For example, a consortium led by TU Delft will start work on a detailed virtual model of the Dutch energy system. In another project, a consortium of UMC Utrecht is developing an MRI scanner that can scan people in motion.
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U Utrecht-CBDD @uu-cbdd.bsky.social · 09/07/2025
New JACS @pubs.acs.org @acs.org paper from the Boons Group, spearheaded by Mehman @complement.bsky.social describes the chemoenzymatic synthesis of intact HNK-1 glycolipids, which were used to glycoengineer erythrocyte surface for binding and lysis assays. pubs.acs.org/doi/10.1021/...
pubs.acs.org
Chemoenzymatic Synthesis of Glycosphingolipids Having an HNK-1 Epitope for Erythrocyte Cell Surface Remodeling
Several neuropathies, such as Guillain–Barré syndrome and myelin-associated glycoprotein neuropathy (MAG), are caused by antibodies targeting glycosphingolipids. Several studies have indicated that MA...
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Reposted by U Utrecht-CBDD
Bijvoet Centre @bijvoet-centre.bsky.social · 12/05/2025
Great to have almost the entire Bijvoet Centre together for our 2025 Bijvoet Symposium! Looking forward to a lot of exciting science!
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Reposted by U Utrecht-CBDD
Robert de Vries @rpdevrieslab.bsky.social · 09/05/2025
Happy to be able to contribute to this very cool preprint Characterization of the glycoproteins of novel fish influenza B-like viruses #glycotime #lovevirology @uu-cbdd.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Characterization of the glycoproteins of novel fish influenza B-like viruses
Novel influenza-like virus sequences previously identified in fish and amphibians were found to cluster as a sister clade of influenza B viruses, but have thus far remained uncharacterized. We demonst...
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Reposted by U Utrecht-CBDD
Nathanael B. Kegel @nathanaelbkegel.bsky.social · 19/03/2025
Excited to share our preprint about proteins that we found in preparations of glycoRNAs now available on bioRxiv! #glycotime (1/9) www.biorxiv.org/content/10.1...
biorxiv.org
Proteins are a source of glycans found in preparations of glycoRNA
Recent discoveries show that RNA can be modified with sialylated glycans (termed glycoRNA), thus broadening our understanding of cellular glycosylation beyond traditional proteins and lipids. However,...
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U Utrecht-CBDD @uu-cbdd.bsky.social · 18/03/2025
Another heads-up for the #glycoRNA community from Uni Marburg👇There are many glycoproteins co-isolated with RNA by TRIzol method. They persist throughout RNA sample processing and are not easily degraded by proteinase K. Careful what you are looking at in an RNA blot!
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Reposted by U Utrecht-CBDD
Robert de Vries @rpdevrieslab.bsky.social · 19/12/2024
Save the date! #glycotime @uu-cbdd.bsky.social
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U Utrecht-CBDD @uu-cbdd.bsky.social · 18/12/2024
Hello, Bluesky community! Let our first post be a good news: CBDD researchers Geert-Jan Boons and Rob de Vries (@rpdevrieslab.bsky.social), together with researchers in ErasmusMC Rotterdam, were awarded an #ENW-XL from the Dutch Research Council. Stay tuned for #phd/#post-doc openings! #glycotime
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