Shane Liddelow @liddelowsa.bsky.social · 05/08/2026Exciting paper alert. Bravo to @borderbiologist.bsky.social and everyone who worked on the paper. 0101
Shane Liddelow @liddelowsa.bsky.social · 10/07/2026Just a short walk from outside the poster hall to inside the poster hall at #FENS2026 🫠 On the plus side: getting my steps in for extra patatas bravas later 😬 3120
Shane Liddelow @liddelowsa.bsky.social · 29/06/2026One to watch, and one to join! New lab alert. Go A Prof Prakash! 0102
Shane Liddelow @liddelowsa.bsky.social · 20/05/2026Congrats! Try and enjoy the ride while learning all the next new things this job requires of you incredibly quickly 120
Reposted by Shane LiddelowMelissa Cooper, PhD @melcooperphd.bsky.social · 04/05/2026Interested in finding your own astrocyte networks? The plasmid is now available on Addgene! www.addgene.org/252501/ Check out how we implemented it in this paper, published in Nature: www.nature.com/articles/s41... Need extra guidance? Watch this space for a more detailed protocol paper soon!nature.comAstrocytes connect specific brain regions through plastic networks - NatureCommunication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes. 0329
Shane Liddelow @liddelowsa.bsky.social · 18/05/2026Sorry all, some gliaseq datasets went down over the weekend. They should be up and functioning again soon (if not already). Please do reach out if there are additional bugs. MORE data coming soon!static.klipy.comDavid Rose: And For That I Am ApologeticALT: David Rose: And For That I Am Apologetic 020
Reposted by Shane LiddelowUK Glia Network @ukglia.bsky.social · 18/05/2026LAST DAY TO REGISTER www.physoc.org/events/uk-gl... please repostphysoc.orgUK Glia 2026UK Glia 2026 meeting will highlight the pivotal role of glia in brain physiology, offering invaluable insights for those investigating glia function in both health and disease. Find out more about the... 036
Shane Liddelow @liddelowsa.bsky.social · 23/04/2026Yeah, lots of exciting options for follow up studies here! 000
Reposted by Shane LiddelowMelissa Cooper, PhD @melcooperphd.bsky.social · 22/04/2026Astrocytes do so much more than any of us thought - they even communicate among specific brain regions across hemispheres! The journey to this paper spanned nearly a decade, but I'm most excited to see what everyone else does with the tools we've built. There's so much for all of us to explore!nature.comAstrocytes connect specific brain regions through plastic networks - NatureCommunication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes. 1016475
Shane Liddelow @liddelowsa.bsky.social · 22/04/2026Feeling like learning about a secret astrocyte network in the brain? Check out the latest from @melcooperphd.bsky.social in @nature.com. www.nature.com/articles/s41... (take two because I'm out of action on the socials!)nature.comAstrocytes connect specific brain regions through plastic networks - NatureCommunication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes. 4548
Shane Liddelow @liddelowsa.bsky.social · 13/04/2026It may not be available everywhere anymore 😢, but it can be read for free on the @sfn.org website if money is tight - www.sfn.org/-/media/SfN/...sfn.org 031
Reposted by Shane LiddelowCharleston Conference on Alzheimer's Disease (CCAD) @the-ccad.bsky.social · 07/04/2026Congratulations Melissa Cooper, PhD of NYU Langone Health, a 2026 New Vision Research Awardee! Her $100K grant will fund “Astrocyte Networks in Alzheimer’s Disease” exploring how brain cell networks drive disease and reveal new therapies. #CCAD2026 #AlzheimersResearch 281
Reposted by Shane LiddelowMariko Bennett @nachoriko.bsky.social · 24/03/2026I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity. 491706568
Shane Liddelow @liddelowsa.bsky.social · 11/12/2025You WISH it had a glia @stephenmath! The combination of astrocyte and tardigrade would be a force for good! (plus interneurons are just glial support cells right?) 010
Shane Liddelow @liddelowsa.bsky.social · 02/12/2025AMAZING PAPER ALERT! www.nature.com/articles/s41... congratulations to @margheritazamboni.bsky.social, @ellorens.bsky.social, and the rest of the team. This one is important and opens up lots of opportunityes.nature.comThe regulatory code of injury-responsive enhancers enables precision cell-state targeting in the CNS - Nature NeuroscienceZamboni et al. reveal how enhancers encode cell-type-specific responses to CNS injury. By combining multiomic profiling, deep learning and in vivo screening, they uncover injury-responsive enhancer lo... 1206
Shane Liddelow @liddelowsa.bsky.social · 02/12/2025Read about one of the fantastic postdocs in the lab - @pryprk.bsky.social. Thanks to The Scientist for running this exciting series! Priya is on the job market atm - so keep your eyes peeled for exciting things to come from her lab soon! :-) 0140
Shane Liddelow @liddelowsa.bsky.social · 19/11/2025#SfN #SocietyForGlia #Astrocytes ENDING STRONG in Astrocyte land here in San Diego. Thanks for being an amazing community, and apologies (one last time) for anyone I missed! Please comment below with extra awesome astrocyte sessions. See you in 2026! 091
Shane Liddelow @liddelowsa.bsky.social · 19/11/2025#SfN25 #SocietyForGlia #Astrocytes penultimate astrocyte sessions for 2025 - let's do this! 060
Shane Liddelow @liddelowsa.bsky.social · 18/11/2025PREPRINTS ON THEIR WORK: Priya - www.biorxiv.org/content/10.1... and www.biorxiv.org/content/10.1... (press - www.npr.org/2024/10/07/n...) Melissa - www.biorxiv.org/content/10.1... (press - www.thetransmitter.org/astrocytes/a...)biorxiv.org 021
Shane Liddelow @liddelowsa.bsky.social · 18/11/2025#SfN #SocietyForGlia STARTING NOW! Ending strong with the last www.liddelowlab.com presentations of the week. @pryprk.bsky.social talking about a world first mouse model for XDP... and OLIGODENDROCYTES! @melcooperphd.bsky.social presenting on astrocyte networks in the mouse forebrain. 1124
Shane Liddelow @liddelowsa.bsky.social · 18/11/2025PREPRINTS ON THEIR WORK: Priya - www.biorxiv.org/content/10.1... and www.biorxiv.org/content/10.1... (press - www.npr.org/2024/10/07/n...) Melissa - www.biorxiv.org/content/10.1... (press - www.thetransmitter.org/astrocytes/a...) 000
Shane Liddelow @liddelowsa.bsky.social · 18/11/2025#SfN25 #SocietyForGlia #Astrocytes IT'S A BIG DAY - if you're unsure what do do this afternoon - it seems just going to poster row C is the best way to spend some time! as always, apologies to those I have missed - please comment below with more sessions and presentations! 040
Shane Liddelow @liddelowsa.bsky.social · 17/11/2025IT'S A BUSY AFTERNOON FOR THE LAB! @mrodea.bsky.social - astrocyte chromatin in reactive astrocytes across the forebrain Nick Kathman - COCKROACH BRAIN ALERT! (is this the largest single cell atlas of an insect brain?) @liddelowsa.bsky.social - multiomic approaches to study astrocyte reacitivity 071
Reposted by Shane LiddelowNYULH Neuroscience @nyulhneuro.bsky.social · 17/11/2025It's a packed day for our researchers at #SfN25. Come say hi! 041
Shane Liddelow @liddelowsa.bsky.social · 17/11/2025Astrocytes and oxytoxin - we got you! NOW! #SfN25 #SocietyForGlia #Astrocytes 030
Shane Liddelow @liddelowsa.bsky.social · 17/11/2025Argh! Sorry! THANKS! There's so many today (and we all know the app is horrible 🫠) 010
Shane Liddelow @liddelowsa.bsky.social · 17/11/2025#SfN25 #SocietyForGlia #Astrocytes Monday is a BUSY day - see you all out there! (apologies for anyone's presentation I missed - please comment below with details) 151
Shane Liddelow @liddelowsa.bsky.social · 16/11/2025#SocietyForGlia #SfN25 #Astrocytes Sunday is a rest day for astrocytes it seems - but still lots of cool stuff to go and see. Apologies again for anyone I missed - please link your presentations below 0110
Shane Liddelow @liddelowsa.bsky.social · 15/11/2025#SocietyForGlia #SfN25 #Astrocytes Astrocyte presentation round up for Day 1. Sorry if I missed anyone, please comment below with others! See you about the conference 1102
Shane Liddelow @liddelowsa.bsky.social · 15/11/2025#SfN25 #SocietyForGlia #Astrocytes @borderbiologist.bsky.social presenting now! Come and learn about a new function for a substate of reactive astrocytes - antigen presentation! 0131
Reposted by Shane LiddelowPriya Prakash @pryprk.bsky.social · 13/11/2025Very happy to have contributed to this new review on Lewy body dementia in @thelancetneuro.bsky.social led by Sonja W. Scholz. We highlight the latest advances in genetics and pathology. @liddelowsa.bsky.social Check it out! www.sciencedirect.com/science/arti...sciencedirect.comAdvances in the genetics and pathology of Lewy body dementiaLewy body dementia is a heterogeneous disease that is underdiagnosed and poorly understood. Pathologically, Lewy body dementia is characterised by the… 0145
Reposted by Shane LiddelowoZgun Gokce @gokcegroup.bsky.social · 11/11/2025In case you were wondering what to do with precisely 150 minutes of your existence @sfn.org #SfN25 #SanDiego. Join our mini-symposium Single-Cell Multiomics in CNS Injury and Recovery. Guaranteed to contain many glial cells and at least a neuron. I am Co-chairing with Naomi Habib 0104
Shane Liddelow @liddelowsa.bsky.social · 10/11/2025(bonus) thanks to the amazing @droligo.bsky.social and @amygleichman.bsky.social the social aspects of glial biology will be strongly represented. (thanks also to @plasmidsaurus.bsky.social & Avantor for supporting our community!) 072
Shane Liddelow @liddelowsa.bsky.social · 10/11/2025(1/2) preprints: @melcooperphd.bsky.social - astrocyte networks pubmed.ncbi.nlm.nih.gov/40777296/ @mrodea.bsky.social - single cell analysis & diversity www.biorxiv.org/content/10.1... @pryprk.bsky.social - XDP www.biorxiv.org/content/10.1..., www.biorxiv.org/content/10.1... See you in San Diego 152
Shane Liddelow @liddelowsa.bsky.social · 10/11/2025@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below. Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social. (1/2) 15117
Reposted by Shane LiddelowWendy Xin @droligo.bsky.social · 29/10/2025If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal! Date: Monday, Nov 17th Time: 9PM till close Location: The Smoking Gun SD, 555 Market St. All welcome, please free to spread the word! 14012
Reposted by Shane LiddelowGonçalo Castelo-Branco @gocastelobranco.bsky.social · 05/11/2025Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com www.nature.com/articles/s41...nature.comSpatial dynamics of brain development and neuroinflammation - NatureA tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination. 57926
Reposted by Shane LiddelowbioRxiv Neuroscience @biorxiv-neursci.bsky.social · 02/11/2025Oligodendrocytes support functional development of subcortical premotor neurons and navigation www.biorxiv.org/content/10.1101/202… 042
Shane Liddelow @liddelowsa.bsky.social · 24/10/2025We've been doing some amazing stuff outside the astrocyte realm. Check out our latest Oligo investigation led by @pryprk.bsky.social ! 0193
Reposted by Shane LiddelowThe Transmitter @thetransmitter.bsky.social · 04/09/2025Astrocyte networks are much larger than previously thought, which “flips the way we think about astrocytes and what their networks may mean,” says @liddelowsa.bsky.social. By @callimcflurry.bsky.social #neuroskyence www.thetransmitter.org/astrocytes/a... 03311
Shane Liddelow @liddelowsa.bsky.social · 03/09/2025Great story in the @thetransmitter.bsky.social today by @callimcflurry.bsky.social. It was fun chatting about @melcooperphd.bsky.social's new research on astrocyte networks. Read the story here: www.thetransmitter.org/astrocytes/a... Read the preprint here: www.biorxiv.org/content/10.1...thetransmitter.orgAstrocyte networks span large swaths of brainThe networks are plastic, connect brain regions that aren’t connected by neurons and may enable long-distance communication between astrocytes, a new preprint shows. 0227
Shane Liddelow @liddelowsa.bsky.social · 18/08/2025A fantastic time with an excellent group of trainees at the @neurochemistry.org Advanced School. Let the conference begin! 0141
Shane Liddelow @liddelowsa.bsky.social · 15/08/2025are you a PD in the glia (or neuroscience) space? Do you want to come to NYC and give a lecture and meet some amazing faculty here at @nyumedpostdocs.bsky.social? LAST WEEK TO APPLY to be a SPiNES speaker for our next season. Details and apply here: med.nyu.edu/departments-... COME AND WOW US!media.tenor.coma black and white photo of a crowd of people standing and sitting in chairs .ALT: a black and white photo of a crowd of people standing and sitting in chairs . 075
Shane Liddelow @liddelowsa.bsky.social · 13/08/2025Talks will be followed by audience Q&A Speakers: Dr Mollie Lobl, Pediatrician, Montefiore Einstein Alison Singer, Pres &Co-founder, Autism Science Foundation Dr Chiara Manzini, Assoc Prof, Rutgers U Dr Karin Knobe, Global Head of Dev, Rare Diseases, Sanofi Dr Annie Maguire, Postdoc, Einstein Med 030
Shane Liddelow @liddelowsa.bsky.social · 13/08/2025The American Society for Neurochemistry (ASN) and the International Society for Neurochemistry (ISN) are hosting a discussion on autism, with clinical, research, family, & pharma perspectives. August 17, 2025 2-4 PM Hunter College, West Room 714 FREE Registration recommended: lnkd.in/dJY7hp-b 152
Shane Liddelow @liddelowsa.bsky.social · 13/08/2025#GliaPapers #GliaAugust2025 @wiley.com m RESEARCH @micaelaoreilly.bsky.social , …, Veronica Tom Microglial IKKβ alters central and peripheral immune activity at distinct time points after spinal cord injury onlinelibrary.wiley.com/doi/10.1002/...onlinelibrary.wiley.comMicroglial IKKβ Alters Central and Peripheral Immune Activity at Distinct Time Points After Spinal Cord InjuryMicroglial NF-kB signaling increases M1-like spinal microglia over time after spinal cord injury. Microglial NF-kB signaling broadly affects gene expression in spinal cord. Microglial NF-kB signalin... 020
Shane Liddelow @liddelowsa.bsky.social · 13/08/2025#GliaPapers #GliaAugust2025 @wiley.com RESEARCH Thomas Chaigneau, …, Slavica Krantic Subtle alterations in hippo. neuronal activity coincide with early sex-specific differences in amyloidosis & microglia in a pre-symptomatic mouse model of AD-like pathology onlinelibrary.wiley.com/doi/10.1002/...onlinelibrary.wiley.comSubtle Alterations in Hippocampal Neuronal Activity Coincide With Early Sex‐Specific Differences in Amyloidosis and Microglia in a Pre‐Symptomatic Mouse Model of Alzheimer‐Like PathologyIn a pre-symptomatic mouse model of Alzheimer disease, despite higher amyloid-β load females display less plaques than males. More efficient synaptic transmission as well as less microgliosis point ... 110
Shane Liddelow @liddelowsa.bsky.social · 13/08/2025#GliaPapers #GliaAugust2025 @wiley.com RESEARCH Chan Rim, …, Minyeop Nahm, Min-Soo Kwon Nuclear Profilin-1 for DNA damage repair is involved in phagocytic impairment of senescent microglia onlinelibrary.wiley.com/doi/10.1002/...onlinelibrary.wiley.comNuclear Profilin‐1 for DNA Damage Repair Is Involved in Phagocytic Impairment of Senescent MicrogliaCytosolic PFN1 relocates to the nucleus for DNA repair. Senescent microglia show nuclear PFN1 accumulation. Nuclear F-actin impairs phagocytosis in senescent microglia. Cytochalasin D failed to retu... 100
Shane Liddelow @liddelowsa.bsky.social · 13/08/2025#GliaPapers #GliaAugust2025 @wiley.com m RESEARCH Binri Sasaki, …, Nobuharu Suzuki Myelin formation by oligodendrocytes is enhanced through laminin-411 and its derived peptide onlinelibrary.wiley.com/doi/10.1002/...onlinelibrary.wiley.comMyelin Formation by Oligodendrocytes Is Enhanced Through Laminin‐411 and Its Derived PeptideLaminin (LM) α1, α2, and α4 chains are expressed at the myelination stage of oligodendrocyte (OL). LM411 and its E8 fragment enhance OL myelin membrane formation. A4G47 from LM411E8 is a novel pepti... 100