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Shane Liddelow

@liddelowsa.bsky.social
3.2K followers 288 following 332 posts

Neuroscientist and glial aficionado at NYU Grossman School of Medicine/NYU Langone Health in NYC. Posts in my individual/personal capacity. My lab is full of awesome people doing amazing stuff - check them out: www.liddelowlab.com he/him

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Shane Liddelow @liddelowsa.bsky.social · 05/08/2026
Exciting paper alert. Bravo to @borderbiologist.bsky.social and everyone who worked on the paper.
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Shane Liddelow @liddelowsa.bsky.social · 10/07/2026
Just a short walk from outside the poster hall to inside the poster hall at #FENS2026 🫠 On the plus side: getting my steps in for extra patatas bravas later 😬
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Shane Liddelow @liddelowsa.bsky.social · 29/06/2026
One to watch, and one to join! New lab alert. Go A Prof Prakash!
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Shane Liddelow @liddelowsa.bsky.social · 20/05/2026
Congrats! Try and enjoy the ride while learning all the next new things this job requires of you incredibly quickly
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Melissa Cooper, PhD @melcooperphd.bsky.social · 04/05/2026
Interested in finding your own astrocyte networks? The plasmid is now available on Addgene! www.addgene.org/252501/ Check out how we implemented it in this paper, published in Nature: www.nature.com/articles/s41... Need extra guidance? Watch this space for a more detailed protocol paper soon!
nature.com
Astrocytes connect specific brain regions through plastic networks - Nature
Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.
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Shane Liddelow @liddelowsa.bsky.social · 18/05/2026
Sorry all, some gliaseq datasets went down over the weekend. They should be up and functioning again soon (if not already). Please do reach out if there are additional bugs. MORE data coming soon!
static.klipy.com
David Rose: And For That I Am Apologetic
ALT: David Rose: And For That I Am Apologetic
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UK Glia Network @ukglia.bsky.social · 18/05/2026
LAST DAY TO REGISTER www.physoc.org/events/uk-gl... please repost
physoc.org
UK Glia 2026
UK Glia 2026 meeting will highlight the pivotal role of glia in brain physiology, offering invaluable insights for those investigating glia function in both health and disease. Find out more about the...
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Shane Liddelow @liddelowsa.bsky.social · 23/04/2026
Yeah, lots of exciting options for follow up studies here!
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Melissa Cooper, PhD @melcooperphd.bsky.social · 22/04/2026
Astrocytes do so much more than any of us thought - they even communicate among specific brain regions across hemispheres! The journey to this paper spanned nearly a decade, but I'm most excited to see what everyone else does with the tools we've built. There's so much for all of us to explore!
nature.com
Astrocytes connect specific brain regions through plastic networks - Nature
Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.
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Shane Liddelow @liddelowsa.bsky.social · 22/04/2026
Feeling like learning about a secret astrocyte network in the brain? Check out the latest from @melcooperphd.bsky.social in @nature.com. www.nature.com/articles/s41... (take two because I'm out of action on the socials!)
nature.com
Astrocytes connect specific brain regions through plastic networks - Nature
Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.
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Shane Liddelow @liddelowsa.bsky.social · 13/04/2026
It may not be available everywhere anymore 😢, but it can be read for free on the @sfn.org website if money is tight - www.sfn.org/-/media/SfN/...
sfn.org
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Charleston Conference on Alzheimer's Disease (CCAD) @the-ccad.bsky.social · 07/04/2026
Congratulations Melissa Cooper, PhD of NYU Langone Health, a 2026 New Vision Research Awardee! Her $100K grant will fund “Astrocyte Networks in Alzheimer’s Disease” exploring how brain cell networks drive disease and reveal new therapies. #CCAD2026 #AlzheimersResearch
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Mariko Bennett @nachoriko.bsky.social · 24/03/2026
I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity.
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Shane Liddelow @liddelowsa.bsky.social · 11/12/2025
You WISH it had a glia @stephenmath! The combination of astrocyte and tardigrade would be a force for good! (plus interneurons are just glial support cells right?)
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Shane Liddelow @liddelowsa.bsky.social · 02/12/2025
AMAZING PAPER ALERT! www.nature.com/articles/s41... congratulations to @margheritazamboni.bsky.social, @ellorens.bsky.social, and the rest of the team. This one is important and opens up lots of opportunityes.
nature.com
The regulatory code of injury-responsive enhancers enables precision cell-state targeting in the CNS - Nature Neuroscience
Zamboni et al. reveal how enhancers encode cell-type-specific responses to CNS injury. By combining multiomic profiling, deep learning and in vivo screening, they uncover injury-responsive enhancer lo...
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Shane Liddelow @liddelowsa.bsky.social · 02/12/2025
Read about one of the fantastic postdocs in the lab - @pryprk.bsky.social. Thanks to The Scientist for running this exciting series! Priya is on the job market atm - so keep your eyes peeled for exciting things to come from her lab soon! :-)
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Shane Liddelow @liddelowsa.bsky.social · 19/11/2025
#SfN #SocietyForGlia #Astrocytes ENDING STRONG in Astrocyte land here in San Diego. Thanks for being an amazing community, and apologies (one last time) for anyone I missed! Please comment below with extra awesome astrocyte sessions. See you in 2026!
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Shane Liddelow @liddelowsa.bsky.social · 19/11/2025
#SfN25 #SocietyForGlia #Astrocytes penultimate astrocyte sessions for 2025 - let's do this!
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Shane Liddelow @liddelowsa.bsky.social · 18/11/2025
PREPRINTS ON THEIR WORK: Priya - www.biorxiv.org/content/10.1... and www.biorxiv.org/content/10.1... (press - www.npr.org/2024/10/07/n...) Melissa - www.biorxiv.org/content/10.1... (press - www.thetransmitter.org/astrocytes/a...)
biorxiv.org
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Shane Liddelow @liddelowsa.bsky.social · 18/11/2025
#SfN #SocietyForGlia STARTING NOW! Ending strong with the last www.liddelowlab.com presentations of the week. @pryprk.bsky.social talking about a world first mouse model for XDP... and OLIGODENDROCYTES! @melcooperphd.bsky.social presenting on astrocyte networks in the mouse forebrain.
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Shane Liddelow @liddelowsa.bsky.social · 18/11/2025
PREPRINTS ON THEIR WORK: Priya - www.biorxiv.org/content/10.1... and www.biorxiv.org/content/10.1... (press - www.npr.org/2024/10/07/n...) Melissa - www.biorxiv.org/content/10.1... (press - www.thetransmitter.org/astrocytes/a...)
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Shane Liddelow @liddelowsa.bsky.social · 18/11/2025
#SfN25 #SocietyForGlia #Astrocytes IT'S A BIG DAY - if you're unsure what do do this afternoon - it seems just going to poster row C is the best way to spend some time! as always, apologies to those I have missed - please comment below with more sessions and presentations!
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Shane Liddelow @liddelowsa.bsky.social · 17/11/2025
IT'S A BUSY AFTERNOON FOR THE LAB! @mrodea.bsky.social - astrocyte chromatin in reactive astrocytes across the forebrain Nick Kathman - COCKROACH BRAIN ALERT! (is this the largest single cell atlas of an insect brain?) @liddelowsa.bsky.social - multiomic approaches to study astrocyte reacitivity
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NYULH Neuroscience @nyulhneuro.bsky.social · 17/11/2025
It's a packed day for our researchers at #SfN25. Come say hi!
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Shane Liddelow @liddelowsa.bsky.social · 17/11/2025
Astrocytes and oxytoxin - we got you! NOW! #SfN25 #SocietyForGlia #Astrocytes
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Shane Liddelow @liddelowsa.bsky.social · 17/11/2025
Argh! Sorry! THANKS! There's so many today (and we all know the app is horrible 🫠)
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Shane Liddelow @liddelowsa.bsky.social · 17/11/2025
#SfN25 #SocietyForGlia #Astrocytes Monday is a BUSY day - see you all out there! (apologies for anyone's presentation I missed - please comment below with details)
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Shane Liddelow @liddelowsa.bsky.social · 16/11/2025
#SocietyForGlia #SfN25 #Astrocytes Sunday is a rest day for astrocytes it seems - but still lots of cool stuff to go and see. Apologies again for anyone I missed - please link your presentations below
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Shane Liddelow @liddelowsa.bsky.social · 15/11/2025
#SocietyForGlia #SfN25 #Astrocytes Astrocyte presentation round up for Day 1. Sorry if I missed anyone, please comment below with others! See you about the conference
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Shane Liddelow @liddelowsa.bsky.social · 15/11/2025
#SfN25 #SocietyForGlia #Astrocytes @borderbiologist.bsky.social presenting now! Come and learn about a new function for a substate of reactive astrocytes - antigen presentation!
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Priya Prakash @pryprk.bsky.social · 13/11/2025
Very happy to have contributed to this new review on Lewy body dementia in @thelancetneuro.bsky.social led by Sonja W. Scholz. We highlight the latest advances in genetics and pathology. @liddelowsa.bsky.social Check it out! www.sciencedirect.com/science/arti...
sciencedirect.com
Advances in the genetics and pathology of Lewy body dementia
Lewy body dementia is a heterogeneous disease that is underdiagnosed and poorly understood. Pathologically, Lewy body dementia is characterised by the…
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oZgun Gokce @gokcegroup.bsky.social · 11/11/2025
In case you were wondering what to do with precisely 150 minutes of your existence @sfn.org #SfN25 #SanDiego. Join our mini-symposium Single-Cell Multiomics in CNS Injury and Recovery. Guaranteed to contain many glial cells and at least a neuron. I am Co-chairing with Naomi Habib
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Shane Liddelow @liddelowsa.bsky.social · 10/11/2025
(bonus) thanks to the amazing @droligo.bsky.social and @amygleichman.bsky.social the social aspects of glial biology will be strongly represented. (thanks also to @plasmidsaurus.bsky.social & Avantor for supporting our community!)
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Shane Liddelow @liddelowsa.bsky.social · 10/11/2025
(1/2) preprints: @melcooperphd.bsky.social - astrocyte networks pubmed.ncbi.nlm.nih.gov/40777296/ @mrodea.bsky.social - single cell analysis & diversity www.biorxiv.org/content/10.1... @pryprk.bsky.social - XDP www.biorxiv.org/content/10.1..., www.biorxiv.org/content/10.1... See you in San Diego
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Shane Liddelow @liddelowsa.bsky.social · 10/11/2025
@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below. Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social. (1/2)
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Wendy Xin @droligo.bsky.social · 29/10/2025
If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal! Date: Monday, Nov 17th Time: 9PM till close Location: The Smoking Gun SD, 555 Market St. All welcome, please free to spread the word!
A flyer displaying the same information as written in the post, with two images of two astrocytes around a blood vessel and one newly formed oligodendrocyte, along with logs our sponsors Avantor and Plasmidsaurus.
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Gonçalo Castelo-Branco @gocastelobranco.bsky.social · 05/11/2025
Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com www.nature.com/articles/s41...
nature.com
Spatial dynamics of brain development and neuroinflammation - Nature
A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 02/11/2025
Oligodendrocytes support functional development of subcortical premotor neurons and navigation www.biorxiv.org/content/10.1101/202…
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Shane Liddelow @liddelowsa.bsky.social · 24/10/2025
We've been doing some amazing stuff outside the astrocyte realm. Check out our latest Oligo investigation led by @pryprk.bsky.social !
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The Transmitter @thetransmitter.bsky.social · 04/09/2025
Astrocyte networks are much larger than previously thought, which “flips the way we think about astrocytes and what their networks may mean,” says @liddelowsa.bsky.social. By @callimcflurry.bsky.social #neuroskyence www.thetransmitter.org/astrocytes/a...
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Shane Liddelow @liddelowsa.bsky.social · 03/09/2025
thanks for the great insights!
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Shane Liddelow @liddelowsa.bsky.social · 03/09/2025
Great story in the @thetransmitter.bsky.social today by @callimcflurry.bsky.social. It was fun chatting about @melcooperphd.bsky.social's new research on astrocyte networks. Read the story here: www.thetransmitter.org/astrocytes/a... Read the preprint here: www.biorxiv.org/content/10.1...
thetransmitter.org
Astrocyte networks span large swaths of brain
The networks are plastic, connect brain regions that aren’t connected by neurons and may enable long-distance communication between astrocytes, a new preprint shows.
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Shane Liddelow @liddelowsa.bsky.social · 18/08/2025
A fantastic time with an excellent group of trainees at the @neurochemistry.org Advanced School. Let the conference begin!
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Shane Liddelow @liddelowsa.bsky.social · 15/08/2025
are you a PD in the glia (or neuroscience) space? Do you want to come to NYC and give a lecture and meet some amazing faculty here at @nyumedpostdocs.bsky.social? LAST WEEK TO APPLY to be a SPiNES speaker for our next season. Details and apply here: med.nyu.edu/departments-... COME AND WOW US!
media.tenor.com
a black and white photo of a crowd of people standing and sitting in chairs .
ALT: a black and white photo of a crowd of people standing and sitting in chairs .
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Shane Liddelow @liddelowsa.bsky.social · 13/08/2025
Talks will be followed by audience Q&A Speakers: Dr Mollie Lobl, Pediatrician, Montefiore Einstein Alison Singer, Pres &Co-founder, Autism Science Foundation Dr Chiara Manzini, Assoc Prof, Rutgers U Dr Karin Knobe, Global Head of Dev, Rare Diseases, Sanofi Dr Annie Maguire, Postdoc, Einstein Med
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Shane Liddelow @liddelowsa.bsky.social · 13/08/2025
The American Society for Neurochemistry (ASN) and the International Society for Neurochemistry (ISN) are hosting a discussion on autism, with clinical, research, family, & pharma perspectives. August 17, 2025 2-4 PM Hunter College, West Room 714 FREE Registration recommended: lnkd.in/dJY7hp-b
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Shane Liddelow @liddelowsa.bsky.social · 13/08/2025
#GliaPapers #GliaAugust2025 @wiley.com m RESEARCH @micaelaoreilly.bsky.social , …, Veronica Tom Microglial IKKβ alters central and peripheral immune activity at distinct time points after spinal cord injury onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Microglial IKKβ Alters Central and Peripheral Immune Activity at Distinct Time Points After Spinal Cord Injury
Microglial NF-kB signaling increases M1-like spinal microglia over time after spinal cord injury. Microglial NF-kB signaling broadly affects gene expression in spinal cord. Microglial NF-kB signalin...
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Shane Liddelow @liddelowsa.bsky.social · 13/08/2025
#GliaPapers #GliaAugust2025 @wiley.com RESEARCH Thomas Chaigneau, …, Slavica Krantic Subtle alterations in hippo. neuronal activity coincide with early sex-specific differences in amyloidosis & microglia in a pre-symptomatic mouse model of AD-like pathology onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Subtle Alterations in Hippocampal Neuronal Activity Coincide With Early Sex‐Specific Differences in Amyloidosis and Microglia in a Pre‐Symptomatic Mouse Model of Alzheimer‐Like Pathology
In a pre-symptomatic mouse model of Alzheimer disease, despite higher amyloid-β load females display less plaques than males. More efficient synaptic transmission as well as less microgliosis point ...
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Shane Liddelow @liddelowsa.bsky.social · 13/08/2025
#GliaPapers #GliaAugust2025 @wiley.com RESEARCH Chan Rim, …, Minyeop Nahm, Min-Soo Kwon Nuclear Profilin-1 for DNA damage repair is involved in phagocytic impairment of senescent microglia onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Nuclear Profilin‐1 for DNA Damage Repair Is Involved in Phagocytic Impairment of Senescent Microglia
Cytosolic PFN1 relocates to the nucleus for DNA repair. Senescent microglia show nuclear PFN1 accumulation. Nuclear F-actin impairs phagocytosis in senescent microglia. Cytochalasin D failed to retu...
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Shane Liddelow @liddelowsa.bsky.social · 13/08/2025
#GliaPapers #GliaAugust2025 @wiley.com m RESEARCH Binri Sasaki, …, Nobuharu Suzuki Myelin formation by oligodendrocytes is enhanced through laminin-411 and its derived peptide onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Myelin Formation by Oligodendrocytes Is Enhanced Through Laminin‐411 and Its Derived Peptide
Laminin (LM) α1, α2, and α4 chains are expressed at the myelination stage of oligodendrocyte (OL). LM411 and its E8 fragment enhance OL myelin membrane formation. A4G47 from LM411E8 is a novel pepti...
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