iiinova — where your digital self keeps evolving

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Priya Prakash @pryprk.bsky.social · 16/06/2026

I am excited to share that I will be opening my lab as a tenure-track Assistant Professor in the Department of Pharmacological Sciences at Stony Brook University Renaissance School of Medicine, beginning in March 2027. @stonybrooku.bsky.social @stonybrookmedicine.bsky.social www.prakash-lab.org

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Melissa Cooper, PhD @melcooperphd.bsky.social · 22/04/2026

Astrocytes do so much more than any of us thought - they even communicate among specific brain regions across hemispheres! The journey to this paper spanned nearly a decade, but I'm most excited to see what everyone else does with the tools we've built. There's so much for all of us to explore!

nature.com

Astrocytes connect specific brain regions through plastic networks - Nature

Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

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Priya Prakash @pryprk.bsky.social · 01/12/2025

I was featured on The Scientist as a part of their 'Postdoc Portraits' series where I spoke about my scientific career path and ongoing work on oligodendrocyte dysfunction in neurodegeneration. Check it out! www.the-scientist.com/postdoc-port...

the-scientist.com

Postdoc Portrait: Priya Prakash

This postdoc uncovers how glial dysfunction drives neurodegeneration in a rare movement disorder.

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Shane Liddelow @liddelowsa.bsky.social · 18/11/2025

#SfN #SocietyForGlia STARTING NOW! Ending strong with the last www.liddelowlab.com presentations of the week. @pryprk.bsky.social talking about a world first mouse model for XDP... and OLIGODENDROCYTES! @melcooperphd.bsky.social presenting on astrocyte networks in the mouse forebrain.

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Kelsey Nemec @kel-nem.bsky.social · 12/11/2025

📄🚨: Building off a stellar 2023 pub that engineered an hCSF1R variant, Sonia et al. now show how an mCSF1R variant not only confers inhibitor resistance and allows for efficient & non-toxic microglia replacement, but does so after vascular delivery into immunocompetent mice! 👏🧠 tinyurl.com/3wvmm8v3

tinyurl.com

Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells

Microglia replacement holds great promise for the study and treatment of neurological diseases. We previously achieved high-efficiency replacement by …

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Priya Prakash @pryprk.bsky.social · 10/11/2025

Looking forward to presenting our work on oligodendrocyte dysfunction in a rare neurodegenerative movement disorder X-linked Dystonia Parkinsonism. Come say hi if you're around on Tuesday, Nov 18 between 1-5 pm! @sfn.org #SfN2025 #SfN25

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Shane Liddelow @liddelowsa.bsky.social · 10/11/2025

@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below. Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social. (1/2)

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Priya Prakash @pryprk.bsky.social · 24/10/2025

I am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene. Read our two companion papers: 🔹 www.biorxiv.org/content/10.1... 🔹 www.biorxiv.org/content/10.1... 🧵 Highlights below!

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Melissa Cooper, PhD @melcooperphd.bsky.social · 03/09/2025

A big thank you to The Transmitter and @callimcflurry.bsky.social for the spotlight on our preprint! You can check out her article below, or the preprint here: doi.org/10.1101/2025...

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Melissa Cooper, PhD @melcooperphd.bsky.social · 22/07/2025

Now on bioRxiv! Astrocytes in one brain region (cyan) communicate in expansive networks (magenta). Through tool development, tissue clearing, and many hours on our @zeiss-microscopy.bsky.social Z1, we now know these networks are repeatable across mice, plastic, and specific. doi.org/10.1101/2025...

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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 22/07/2025

Astrocytes connect specific brain regions through plastic gap junctional networks www.biorxiv.org/content/10.1101/202…

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Amy Gleichman @amygleichman.bsky.social · 01/05/2025

Thrilled to announce that my lab is now open at Ohio State! We study astrocytes as gene therapy targets for brain repair after ischemic stroke and in vascular dementia, developing new viral tools along the way. If you're interesting in joining or collaborating, please reach out! gleichmanlab.com

gleichmanlab.com

The Gleichman lab

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Mariko Bennett @nachoriko.bsky.social · 30/04/2025

Our lab's 1st paper, led by @fchrisbennett.bsky.social & @waisenberg.bsky.social. A decade thinking how to directly assess the impact of microglia replacement. Yrs of hard work. This kind of work is needed to expand brain disease care for kids & the vision for safer, more effective cell therapy.

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Kelsey Nemec @kel-nem.bsky.social · 30/04/2025

Amped to share this masterclass of a paper spearheaded by @waisenberg.bsky.social, out today in Immunity. Will et al. provide a deeply detailed look into microglia dysfunction in Krabbe disease & show that microglia replacement therapeutically improves disease outcomes! www.cell.com/immunity/ful...

cell.com

Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease

Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular signature of disease-associated ...

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Michael O’Dea @mrodea.bsky.social · 08/04/2025

New preprint evaluating the recent claim of epigenetically regulated immune memory in astrocytes. We believe this finding was likely artifactual, resulting from immune cell contamination & cell type mis-annotation across multiple transcriptomics experiments:

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Melissa Cooper, PhD @melcooperphd.bsky.social · 10/03/2025

Fresh off the press! We found that degeneration in one retina causes astrocytes to respond retinotopically across *both* hemispheres of the brain. Perhaps astrocytes across the CNS are able to coordinate their responses more than we anticipated... www.pnas.org/doi/10.1073/...

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Bethany Brookshire @beebrookshire.bsky.social · 07/03/2025

At @standupforscience.bsky.social and the signs are statistically significantly excellent

A person in a mask holding a painting that says “hands off my transgenic mice”

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Shane Liddelow @liddelowsa.bsky.social · 31/01/2025

#GliaPapers #GliaSpecial2025 REVIEW @mrodea.bsky.social, @philiphasel.bsky.social Are we there yet? Exploring astrocyte heterogeneity one cell at a time onlinelibrary.wiley.com/doi/10.1002/...

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Shane Liddelow @liddelowsa.bsky.social · 31/01/2025

#GliaPapers #GliaSpecialIssue SPECIAL COVER SPECIAL ISSUE: Glial omics: unraveling mechanisms in health and disease onlinelibrary.wiley.com/toc/10981136... Editorial Unboxing “Omics” in Glial Biology to Understand Neurological Disease here - onlinelibrary.wiley.com/doi/10.1002/...

onlinelibrary.wiley.com

Special Issue: Glial omics: Unraveling mechanisms in health and disease: Glia: Vol 73, No 3

Glia is the top neurobiology journal for research into glial cells (also called gliocytes or neuroglia). Articles cover all aspects of glial cell biology in health and disease.

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Ilan Schwartz @germhuntermd.bsky.social · 22/01/2025

Scientific advancements aside, this is economically irresponsible Every $1 spent by NIH generates $2.46 For example, in 2023, $47B in NIH spending generated ~$93B Halting NIH spending will LOSE the US a lot of money (and talent)

An image of NIH campus. Text says : With annual budget of more than $47 billion, NIH is the largest single public funder of biomedical and behavioural research in the world. In fiscal year 2023, NIH funding generated an estimated $92.89 billion in economic activity

Every state and almost every congressional district received a share of NIH investment
Each year, NIH awards over 60,000 grants that directly support more than 300,000 researchers at more than 2,500 different institutions
In fiscal year 2023, every $1 of NIH funding generated approximately $2.46 of economic activity

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Leopold Parts @leopoldparts.bsky.social · 15/01/2025

We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵 www.biorxiv.org/content/10.1...

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Steven Sloan @sloanlab.bsky.social · 08/01/2025

First 🦋 post! Very excited to share our lab's latest work exploring the shared and divergent aspects of human astrocyte development and glioblastoma. This effort spans many fields from developmental #glial biology to #stem cells and #tumor biology. rdcu.be/d5ADz A 🧵

rdcu.be

Mapping the developmental trajectory of human astrocytes reveals divergence in glioblastoma

Nature Cell Biology - Sojka et al. analyse the transcriptomic and epigenomic landscape of human astrocyte maturation and identify an epigenetically regulated intermediate state associated with...

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Shane Liddelow @liddelowsa.bsky.social · 11/12/2024

3 reviews on planning, execution, & validation of transcriptomic experiments in neuroscience published in @natureportfolio.bsky.social #NatureNeuroscience. A MUST READ if you're doing transcriptomics. 3 reviews, an amazing editorial, a beautiful cover – this is the issue of the year! (mini thread)

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Samuel Marsh Ph.D. @samuelmarsh.bsky.social · 03/12/2024

Big day for single cell and neuroscience. Trio of single cell perspective pieces discussing applications, opportunities, challenges, and validation of single cell and spatial genomics in neuroscience are out now in Nature Neuroscience. Links in thread below.👇 1/n

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Philip Hasel @philiphasel.bsky.social · 25/11/2024

PhD opportunity: If you're interested in how astrocytes and the meninges talk to each other and how this is affected in dementia come do your PhD with us in Edinburgh (cc: Karen Horsburgh and Ingo Schiessl)! www.findaphd.com/phds/project...

findaphd.com

(VIDA DTC) Exploring the role of the astrocyte-leptomeningeal vessel interface in dementia at University of Edinburgh on FindAPhD.com

PhD Project - (VIDA DTC) Exploring the role of the astrocyte-leptomeningeal vessel interface in dementia at University of Edinburgh, listed on FindAPhD.com

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Shane Liddelow @liddelowsa.bsky.social · 17/11/2024

There are lots of us missing, but so many joining so quickly Please do share, and comment below to be added go.bsky.app/5f2V6L6 (microglia starter pack also here by @mancusorenzo.bsky.social - bsky.app/starter-pack...)

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