I'm excited to share our latest preprint from the Liddelow lab!
We show that specific cytokines can induce astrocytes to present antigens to CD4+ T cells. More proof that astrocytes can actively shape adaptive immune responses during neuroinflammation.
@liddelowsa.bsky.social
lnkd.in/gjteXwFu
biorxiv.org
IFNγ and proinflammatory cytokines cooperatively license astrocytes to support antigen-dependent CD4+ T cell restimulation
We report that type 2 interferon with proinflammatory cytokines induces astrocytes to express multiple components required for attraction of and antigen presentation to CD4+ T cells via MHC-II molecul...
