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Lesley Weaver

@lesleynweaver.bsky.social
953 followers 307 following 58 posts

Asst. Prof. of Biology | Interested in inter-organ signaling on stem cell lineages | (she,her)

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Reposted by Lesley Weaver
Harmit Singh Malik @harmitmalik.bsky.social · 12/11/2025
Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on. (Please repost to reach a broad audience.)
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Maria de la Paz Fernandez @mariadelapax.bsky.social · 01/10/2025
Come join us! Applications to the GCDB Biology Doctoral program at IU are due December 1st. @iubiology.bsky.social @alizeemalnoe.bsky.social @rhcalderon.bsky.social @lesleynweaver.bsky.social @hoosierflyman.bsky.social @tennessenlab.bsky.social @flyeyelab.bsky.social @briancalvi.bsky.social
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Lesley Weaver @lesleynweaver.bsky.social · 10/09/2025
🤣
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Lesley Weaver @lesleynweaver.bsky.social · 10/09/2025
Steel Magnolias is my movie! I cry/laugh every time I watch the funeral scene…and Daryl Hannah before Kill Bill is a complete 180.
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Lesley Weaver @lesleynweaver.bsky.social · 10/09/2025
I’m really struggling with the fact that people in my lab have never seen “Mrs. Doubtfire” and “Adams Family Values.” I literally had to explain the Thanksgiving scene and re-enact the song. #MillennialPI
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Soni Lacefield @lacefieldlab.bsky.social · 27/08/2025
My department at Dartmouth Medical School is hiring a tenure-track Assistant Professor. We are looking broadly for a biochemist or cell biologist. Please share this add! apply.interfolio.com/171438 @dartmouthbcb.bsky.social @futurepislack.bsky.social
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Lesley Weaver @lesleynweaver.bsky.social · 26/08/2025
Collectively, our results highlight a role for amino acid storage proteins in regulating stem cell lineages in Drosophila.
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Lesley Weaver @lesleynweaver.bsky.social · 26/08/2025
Lastly, we found that adipocyte-derived storage proteins regulate TOR signaling directly in GSCs.
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Lesley Weaver @lesleynweaver.bsky.social · 26/08/2025
We also found that the predicted storage protein receptors (Fbp1 and Fbp2) are present in ovarian follicle cells and Lsp2 is present in the oocyte.
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Lesley Weaver @lesleynweaver.bsky.social · 26/08/2025
We found that larval serum proteins (LSPs) are expressed in adult female adipocytes (at significantly lower levels compared to larvae) and are required for maintaining GSC number.
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Lesley Weaver @lesleynweaver.bsky.social · 26/08/2025
In this study we investigated the role of adipocyte-derived amino acid storage proteins in regulating germline stem cell (GSC) maintenance in the adult ovary.
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Lesley Weaver @lesleynweaver.bsky.social · 26/08/2025
My lab’s newest preprint is now available. www.biorxiv.org/content/10.1...
biorxiv.org
Adipocyte-Derived Amino Acid Storage Proteins are Required for Germline Stem Cell Maintenance in Adult Drosophila Females
Tissue homeostasis is dependent on precise coordination between endocrine organs in response to changes in organism physiology. Secreted circulating factors from adipocytes (called adipokines) regulat...
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Bloomington Drosophila Stock Center @bdsc.bsky.social · 15/08/2025
FlyBase needs your help! Visit the link below for more information, and please consider donating to help save this amazing resource. wiki.flybase.org/wiki/FlyBase...
wiki.flybase.org
FlyBase:Contribute to FlyBase - FlyBase Wiki
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Lesley Weaver @lesleynweaver.bsky.social · 21/08/2025
RIP to Bloomington summer life. Not ready for all of the meetings...and "traffic."
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FlyBase @flybase.bsky.social · 15/08/2025
FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...
wiki.flybase.org
FlyBase:Contribute to FlyBase - FlyBase Wiki
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@LaBonneLaB @labonnelab.bsky.social · 26/07/2025
Some journals are claiming that you need to pay big $$ for gold open access to comply with NIH's new public access policy. FYI that is total bs. You can comply by depositing the Accepted Manuscript into PubMed Central on the Date of Publication without embargo. Pass it on.
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Dr Sian Gramates @drglam.bsky.social · 25/06/2025
A news article about the project I work for.
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Jason Rasgon @vectorgen.bsky.social · 01/08/2023
I guess I should re-post from the Bird Site "The Rules For Academic Success here": I always get asked for advice about starting/surviving the tenure track. Here are the rules I've found useful. Thought I'd put it out there for the masses... This list gets longer all the time
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Lesley Weaver @lesleynweaver.bsky.social · 18/06/2025
Congrats!
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Lesley Weaver @lesleynweaver.bsky.social · 18/06/2025
I've reached that PI stage where I realize I'm about to suggest an experiment that is more "instant gratification" in getting an answer, but way more annoying to do...so I'm going to insist on the "annoying" experiment of course!
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Lesley Weaver @lesleynweaver.bsky.social · 18/06/2025
Congrats Beronda! Is there a way to pre-order?
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Beronda L. Montgomery @berondam.bsky.social · 18/06/2025
Some advance copies of my next book "When Trees Testify" have gone out into the world. Release date: January 20, 2026 What a journey it has been thus far, and looking forward to the continuing journey ahead. #WhenTreesTestify #WhenTreesTestifyTheBook
Image of stack of four copies of the book "When Trees Testify" by Beronda Montgomery with text above that reads "#WhenTreesTestify Coming Jan. 2026'"
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Brian Calvi @briancalvi.bsky.social · 16/06/2025
Thanks to all who have expressed a willingness to support FlyBase. The wheels of bureaucracy are large and grind slowly. We expect to have a fee process in place by July. @flybase.bsky.social
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Christophe Veltsos @drinfosec.bsky.social · 16/06/2025
🚨🧵shared by Prof @michael-hoerger.bsky.social on the word choices researchers have to carefully balance if they want to be considered for funding via US federal sources: threadreaderapp.com/thread/19347... Link to the tool Mike used (tool from @drseanmullen.bsky.social): tinyurl.com/scanassist
1) Here's a quick example of how the federal government is censoring the best scientific research. It's not just cuts to ongoing research. 

It's new grant submissions too...

Below the text is  a screenshot showing two sentences:
"Scan completed"
and
"No forbidden words found"
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Karen James @kejames.bsky.social · 07/06/2025
This gift link needs to be shared far and wide. All of the NIH cancellations and delays in one place with several infographics for exploring them. 🧪
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Matthew Hahn @3rdreviewer.bsky.social · 06/06/2025
Our paper (w/ @smishra677.bsky.social) is now out in Genetics! academic.oup.com/genetics/adv...
academic.oup.com
Estimating recombination using only the allele frequency spectrum
Abstract. Standard methods for estimating the population recombination parameter, ρ, are dependent on sampling individual genotypes and calculating various
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FlyBase @flybase.bsky.social · 03/06/2025
We currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.
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Peter Gleick @petergleick.bsky.social · 31/05/2025
There are 2 previous historical cases of countries destroying their science and universities, crippling them for decades: Lysenkoism in the USSR and Nazi Germany. The Trump administration will be the 3rd. It's not just budgets but research, institutions, expertise, and training the next generation.
Graphs showing 25 years of budgets for the National Institute of Health, NASA, and the NSF. In all cases, the proposed budget for next year is far, far below any year of the previous quarter century.
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Lesley Weaver @lesleynweaver.bsky.social · 24/05/2025
@briancalvi.bsky.social at IU has been working real hard all week to deal with this. Don’t freak out…yet.
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Gc Rox @gcrox.bsky.social · 23/05/2025
All of NIH funding to Northwestern University is frozen. This pause includes noncompeting approved funding, new and competing grants with fundable scores. No reimbursements for money already spent have been received since March. This situation is rarely reported so please Please get the word out!
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Jeremy Berg @jeremymberg.bsky.social · 23/05/2025
Senator Durbin noted that some (I believe Republican Senators) had indicated the US had been doing more than its share of biomedical research and it was time for other countries take a turn. I felt I had to interrupt to respond...
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Kate @dubchi5.bsky.social · 23/05/2025
I don’t think the general public understands how much international students help keep colleges going. Not just from an intellectual and cultural aspect… but purely financial. They generally pay higher costs for tuition, have to spend more in housing and food on campus, and pay cash.
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Clara Jeffery @clarajeffery.bsky.social · 22/05/2025
If you do in fact want Covid boosters for yourself or anyone, you can submit public comment to the FDA here: www.regulations.gov/commenton/FD...
regulations.gov
Regulations.gov
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Lesley Weaver @lesleynweaver.bsky.social · 22/05/2025
Asking for a friend...is there any university in the US that still has a diversity, equity, and inclusion office on campus?
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ᑕᕼᗴᖇYᒪ @cheryl2877.bsky.social · 19/05/2025
~ Pope Leo ~
To be called woke in a world that sleeps through suffering is no insult 

~ Pope Leo ~
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Carl T. Bergstrom @carlbergstrom.com · 19/05/2025
"to run a contest that you end up not funding as a private organization at this time is… both extremely wasteful of these people’s time, and just devastating in terms of morale." I spoke with @aniloza.bsky.social at STAT today about HHMI's decision not to fund this round of Hanna Gray applicants.
statnews.com
Private funder HHMI pauses postdoc fellowship
As HHMI pauses Hanna Gray fellowship applications, opportunities for young scientists shrink further, making them look overseas.
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Lesley Weaver @lesleynweaver.bsky.social · 19/05/2025
Thank you!
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Lesley Weaver @lesleynweaver.bsky.social · 19/05/2025
Thank you!
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Lesley Weaver @lesleynweaver.bsky.social · 19/05/2025
Thank you! :)
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@LaBonneLaB @labonnelab.bsky.social · 19/05/2025
It is beyond disturbing when the NIH and HHS Directors do not understand that animal models are essential in research www.statnews.com/2025/05/19/a...
statnews.com
There is no replacement (yet) for animal models in medical research
The NIH is “reducing animal use in research.” But there is no replacement for animal models.
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Lesley Weaver @lesleynweaver.bsky.social · 19/05/2025
The final version of my lab’s recent paper on the role of estrogen related receptor in regulation of germline stem cells is now available in @devbiol.bsky.social. You can read the full text here: www.sciencedirect.com/science/arti...
sciencedirect.com
Estrogen-related receptor is required in adult Drosophila females for germline stem cell maintenance
Adult tissue function is dependent on intrinsic factors that mediate stem cell self-renewal and proliferation in response to changes in physiology and…
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Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 13/05/2025
important historical perspective on the value of federal funding of basic research at universities: "These are the building blocks of America's extraordinary strength, created over the last 100 years, and they are now being dismantled in 100 days" 🧪 www.youtube.com/watch?v=0Qk4...
youtube.com
Fareed’s Take: Trump is gutting what made American science great
YouTube video by CNN
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Alizée Malnoë @alizeemalnoe.bsky.social · 09/05/2025
Here’s our final review for this semester prereview.org/reviews/1536... #PreprintReview via @prereview.bsky.social @asapbio.bsky.social @iubiology.bsky.social Looking forward to discussion 🪰💡🩵! #neuroscience #drosophila #photoreceptor #redox @flybase.bsky.social @bdsc.bsky.social
prereview.org
PREreview of “One-carbon metabolism enzyme Ahcy is a redox sensor that modulates gene expression to protect against light stress-induced retinal degeneration”
Authored by Alizée Malnoë, Mandkhai Molomjamts, Sally Abulaila, Madaline McPherson, Habib Ogunyemi, and 5 other authors
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Rua M. Williams @fractalecho.bsky.social · 03/05/2025
If you're a grad student or an undergrad interested in research I need to you listen to me very carefully. You cannot learn to write good research papers if you do not read good research papers. Stop asking LLMs to summarize papers for you.
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Elizabeth Rideout @ejrideout.bsky.social · 03/05/2025
So proud of this preprint! The main paper from Puja Biswas @pujabiswas.bsky.social PhD revealing a female-biased role for the insulin/insulin-like growth factor signaling pathway (IIS) pathway in regulating body fat in fruit flies www.biorxiv.org/content/10.1...
biorxiv.org
Insulin/insulin-like growth factor signaling pathway promotes higher fat storage in Drosophila females
In Drosophila , adult females store more fat than males. While the mechanisms that restrict body fat in males are becoming clearer, less is known about how females achieve higher fat storage. Here, we...
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Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 01/05/2025
"Virtually all NIH-funded training programs aimed at attracting underrepresented groups to science are now gone. 'I’m concerned that these events are very likely to affect who decides to stay in science and we will lose important and necessary scientific talent'" www.science.org/content/arti...
science.org
NIH insiders: Trump is ‘dismantling and destroying everything’
After just 100 days, agency scientists say U.S. health institutes are demoralized and have lost essential staff and funding
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Lesley Weaver @lesleynweaver.bsky.social · 30/04/2025
Thank you so much for transcribing!
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Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 30/04/2025
"I would not have dared to dream that metastatic melanoma would become a treatable disease in my lifetime. Yet here we are today, with 43% of people diagnosed with metastatic melanoma living 10 years or more, due to treatments that we broadly refer to as cancer immunotherapy." Barry P. Sleckman, UAB
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