Compartmentalized inflammation is a key driver of multiple sclerosis (MS) progression, but the mechanisms sustaining its persistence remain unclear. A…

Myelination of CNS axons requires oligodendrocytes to undergo extensive morphological changes by producing large amounts of myelin membrane with defined protein composition and structure. The formatio...

Emerging evidence highlights the dual role of oligodendrocytes in Alzheimer’s disease, both providing protective mechanisms against the pathology and contributing to its progression.

Aging leads to a decrease in white matter volume and damage to myelinated axons, contributing to neurodegeneration. Myelin breakdown can trigger inflammation, creating a vicious cycle that causes further damage. Understanding these changes is key to preventing age-related neurodegenerative disease.

The major pathological feature of Parkinson ‘s disease (PD), the second most common neurodegenerative disease and most common movement disorder, is the predominant degeneration of dopaminergic neurons...

The role of microglia in Alzheimer’s disease is debated. This paper shows that homeostatic microglia seed amyloid plaques in early disease stages and activated microglia compact plaques at later stage...