Reposted by Géraldine LalouxCoralie Tesseur @coralietesseur.bsky.social · 09/07/2026So excited to share our new preprint! 🎉🤩 Check it out to discover how we investigated the role and spatiotemporal dynamics of an essential Tad nanomachine during the lifecycle of our favorite bacterial predator, B.bacteriovorus 🦠 Many thanks to everyone who made this work possible! 0166
Géraldine Laloux @lalouxlab.bsky.social · 09/07/2026🙏 Authors: @coralietesseur.bsky.social @remidenise.bsky.social @ysantin.bsky.social Funding: 🇪🇺 @erc.europa.eu @embo.org 🇧🇪 F.R.S.-FNRS, WEL-RI Support: UCLouvain, de Duve Institute 030
Géraldine Laloux @lalouxlab.bsky.social · 09/07/2026New preprint! We show that the bacterial predator B. bacteriovorus deploys a unipolar Tad nanomachine for irreversible attachment to prey and invasion. @coralietesseur.bsky.social used CRISPRi+microfluidics to overcome barriers associated with essential systems in an obligate predatory lifestyle 🦠biorxiv.orgA polarity-controlled Tad nanomachine enables prey invasion in a bacterial predatorType IV pili are dynamic surface appendages assembled by envelope-spanning nanomachines that mediate diverse bacterial interactions, yet how these systems are adapted to predatory lifestyles remains p... 24717
Géraldine Laloux @lalouxlab.bsky.social · 15/05/2026Today is the last day to submit your abstract for the EMBO Bacterial Networks (BacNet) meeting #EMBOBacNet! 🧫 Selected participants will be informed by June 30th. meetings.embo.org/event/26-bac...meetings.embo.orgBacterial networksBuilding on recent breakthroughs in structural, imaging, and systems-wide approaches, this EMBO Workshop will showcase novel insights into the spatiotemporal organization and interconnectivity of com… 066
Reposted by Géraldine LalouxMelanie Blokesch @mblokesch.bsky.social · 29/03/2026Open postdoc position in my lab on HGT and interbacterial competition. We seek candidates with a PhD in microbiology (or related fields)+ strong 1st-author publications. Curious, highly motivated, and dedicated team players ready to contribute fully are encouraged to apply. Details: tiny.cc/cz01101tiny.ccOpen Positions- 06480
Reposted by Géraldine LalouxGéraldine Laloux @lalouxlab.bsky.social · 20/11/2025Apply now to attend the next EMBO Bacterial Networks meeting #EMBOBacNet 🗓️13-18 September 2026 📍Sant Feliu de Guixols, Spain 📝Program and registration info: meetings.embo.org/event/26-bac... 👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social #MicroSky 15737
Reposted by Géraldine LalouxFusion Conferences @fusionconf.bsky.social · 16/03/2026ANNOUNCEMENT! Programme now LIVE on our website for the #ProkaryoticCellBio conference! Check it out here, a reminder that the registration deadline is 13 April!➡️https://bit.ly/4rEH9KP 237
Géraldine Laloux @lalouxlab.bsky.social · 05/03/2026#MicroSky Please RT @erc.europa.eu-funded postdoc position in my lab to identify the molecular basis of prey-predator interactions using our favorite micro-vampire Bdellovibrio exovorus as a model. Let's find what the bite is made of! 🧛 Flexible start date. Info: euraxess.ec.europa.eu/jobs/415877euraxess.ec.europa.euPostdoctoral researcher in molecular and cellular bacteriology - ERC CoG VAMPIREThe research group of Prof Géraldine Laloux at the de Duve Institute (UCLouvain) is looking for a highly motivated postdoc to elucidate the molecular factors underlying bacterial prey-predator interac... 02025
Géraldine Laloux @lalouxlab.bsky.social · 26/02/2026Fantastic thread and data by @brunlabcaulo.bsky.social on how a single ATPase powers opposite pilus extension/retraction activities. 022
Reposted by Géraldine LalouxAnthony Vecchiarelli @cellforganized.bsky.social · 12/12/2025Just got word that we are a go for the Bacterial Cell Biology and Development GRS and GRC at Southern New Hampshire University! GRS will be on June 5-6, 2027 GRC will be from June 6-11, 2027 Block off your calendars Prokaryotic Cell Biologists! More details to come! Please repost! 36337
Reposted by Géraldine LalouxNathan Fraikin @nfrk92.bsky.social · 10/12/2025academic.oup.com/nar/article/... Collaboration with Y. Yamaichi. Killing donor bacteria in conjugation mixes using water enables transcriptomic profiling of early plasmid genes ! Superb tool for studying zygotic induction of these early genes, which include anti-SOS and anti-RM factors. #microskyacademic.oup.comSelective elimination of donor bacteria enables global profiling of plasmid gene expression at early stages of conjugationAbstract. Conjugative plasmids are a major driving force for the dissemination of antimicrobial resistance. During conjugation, plasmid DNA is transferred 03319
Reposted by Géraldine LalouxClare T 🏳️🌈 @claret-micro.bsky.social · 09/12/2025Your societies need you #MicroSky! Editorial from the European Academy of Microbiology Task Force: Society journals matter—supporting science through renewed commitment: academic.oup.com/microlife/ar...academic.oup.comEditorial: society journals matter—supporting science through renewed commitmentScientific publishing is in flux. Commercial publishers have expanded their influence, driven by profit margins and citation metrics. At the same time, a g 0138
Reposted by Géraldine LalouxJovana Kaljević ⬜️ @jovanakaljevic.bsky.social · 04/12/2025Our preprint is now published in PNAS! This came together thanks to a great collaboration with Antoine Hocher and a strong team effort from the Le Lab. Thank you to the reviewers and to everyone who helped improve it. I hope ParB aficionados will enjoy it. www.pnas.org/doi/10.1073/...pnas.orgVersatile NTP recognition and domain fusions expand the functional repertoire of the ParB-CTPase fold beyond chromosome segregation | PNASNucleotide triphosphate (NTP)-dependent molecular switches regulate essential cellular processes by cycling between active and inactive states thro... 23618
Géraldine Laloux @lalouxlab.bsky.social · 20/11/2025Apply now to attend the next EMBO Bacterial Networks meeting #EMBOBacNet 🗓️13-18 September 2026 📍Sant Feliu de Guixols, Spain 📝Program and registration info: meetings.embo.org/event/26-bac... 👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social #MicroSky 15737
Reposted by Géraldine LalouxMichael Deghelt @michaeldeghelt.bsky.social · 13/11/2025The diderm cell envelope is not a stack of layers but a unified scaffold of Inner Membrane–Peptidoglycan–Outer Membrane. We discuss how tethering the OM to the PG in E. coli preserves integrity — and extend the concept across diderm bacteria. Curr Opin Microbiol: doi.org/10.1016/j.mi... #microsky 🔬doi.orgRedirecting 23319
Reposted by Géraldine LalouxYves Brun lab @brunlabcaulo.bsky.social · 06/11/2025Great collaboration with @guo-lab.bsky.social to determine an in situ architectural model of the Tad pilus machine. Be on the lookout soon for a preprint on the same topic by Grant Jensen and @viollierpat.bsky.social. #microsky 14918
Reposted by Géraldine LalouxMartin Thanbichler @thanbichlerlab.bsky.social · 02/11/2025📢 Postdoc position: Cell Biology of Cyanobacteria in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany. More information at shorturl.at/wNnDT (see Project 2) 🔗Apply at shorturl.at/VsEDl 📅Deadline: Nov 16, 2025 Please repost. #Postdoc 25452
Reposted by Géraldine LalouxbioRxiv Microbiology @biorxiv-microbiol.bsky.social · 10/10/2025Versatile NTP recognition and domain fusions expand the functional repertoire of the ParB-CTPase fold beyond chromosome segregation www.biorxiv.org/content/10.1101/202… 074
Reposted by Géraldine LalouxRenske van Raaphorst 🟥 @vrrenske.bsky.social · 26/09/2025Happy to finally show our story of the connection between nucleoid conformation, transcription & predation in our favorite predator Bdellovibrio bacteriovorus. 🧵 1/n 13111
Géraldine Laloux @lalouxlab.bsky.social · 25/09/2025Experiments and analysis led by former post-doc @vrrenske.bsky.social in collaboration with @tunglejic.bsky.social & @rkoszul.bsky.social teams 010
Géraldine Laloux @lalouxlab.bsky.social · 25/09/2025📝New preprint! #MicroSky 🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy. 🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation. www.biorxiv.org/content/10.1...biorxiv.orgDynamics and interplay of gene expression and chromosome organization across a predatory lifecycleThe obligate predatory bacterium Bdellovibrio bacteriovorus alternates between a motile attack phase and a growth phase inside another bacterium, during which it undergoes multiple rounds of DNA repli... 16338
Géraldine Laloux @lalouxlab.bsky.social · 17/09/2025🇪🇺 Smooth publishing experience with #microLife, the new @femsjournals.bsky.social journal of the European Academy for Microbiology. 🙏 @erc.europa.eu, F.R.S-FNRS & WEL-RI for support 4/4 152
Géraldine Laloux @lalouxlab.bsky.social · 17/09/2025🛠️This is the result of a long and careful work conducted by our research tech Charles de Pierpont, with help from PhD student Benoît Derneden and former lab member @remyophe.bsky.social, and validation by the whole team 3/4 130
Géraldine Laloux @lalouxlab.bsky.social · 17/09/2025🍝 Featuring the reversible spaghetti phenotype of #FtsZ -depleted Bdellovibrio: predator cell division is not required to exit the prey 2/4 120
Géraldine Laloux @lalouxlab.bsky.social · 17/09/2025🚨New paper out! #MicroSky Studying obligate predators like Bdellovibrio bacteriovorus is tricky—essential genes for predation are also essential for survival. We expanded its genetic toolbox: 🧬promoters to fine-tune expression 🧬IPTG-inducible system 🧬CRISPRi for rapid knockdown bit.ly/46GUn2c 1/4academic.oup.comExpanding the genetic toolbox of the obligate predatory bacterium Bdellovibrio bacteriovorus with inducible gene expression and CRISPR interferenceInducible gene expression and CRISPR interference-mediated depletion in the predatory bacterium Bdellovibrio bacteriovorus. 25922
Géraldine Laloux @lalouxlab.bsky.social · 21/08/2025Another great contribution to the “Cell Regulation” themed issue of Current Opinion in Microbiology www.sciencedirect.com/special-issu...sciencedirect.comCurrent Opinion in Microbiology | Cell regulation (2025) | ScienceDirect.com by ElsevierRead the latest articles of Current Opinion in Microbiology at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature 031
Géraldine Laloux @lalouxlab.bsky.social · 12/08/2025Inspiring “behind the paper” story here 👉 communities.springernature.com/posts/out-of... #MicroSkycommunities.springernature.comOut Of The Blue, It Came To Me 040
Géraldine Laloux @lalouxlab.bsky.social · 29/07/2025Bacterial cell wall & periplasm paradigm shift - important read #MicroSky www.nature.com/articles/s41...nature.comPeptidoglycan–outer membrane attachment generates periplasmic pressure to prevent lysis in Gram-negative bacteria - Nature MicrobiologyOuter membrane attachment to peptidoglycan enables periplasmic pressure to build up and counter cytoplasmic turgor pressure, preventing lysis during osmotic challenges in Escherichia coli. 13318
Reposted by Géraldine LalouxDaniela Barillà @danielabarilla.bsky.social · 26/07/2025Chromosome enthusiasts, York is calling! Join us at The Biology & Physics of Chromosomes www.eventsforce.net/biochemsoc/f... Late breaking abstract deadline 📆 7 August @biophychrom.bsky.social @vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social #microsky 01411
Géraldine Laloux @lalouxlab.bsky.social · 26/07/2025Thanks, Basile! All figures were drawn manually ✏️ 🖌️ by Coralie! @coralietesseur.bsky.social 120
Géraldine Laloux @lalouxlab.bsky.social · 25/07/2025#MicroSky Summer read! Predatory bacteria kill and eat other bacteria. Their deadly actions come in many flavors, often via direct physical contact between predator & prey 🧛 How do they do it? Our review 📖 @coralietesseur.bsky.social @ysantin.bsky.social www.sciencedirect.com/science/arti...sciencedirect.comStrategies and mechanisms of contact-dependent predation in bacteriaPredatory bacteria kill other bacteria to acquire nutrients. Among diverse strategies to kill and feed on prey, contact-dependent predation stands out… 25823
Géraldine Laloux @lalouxlab.bsky.social · 16/07/2025Congrats to first author of both chapters @coralietesseur.bsky.social as well as @remyophe.bsky.social and @ysantin.bsky.social 030
Géraldine Laloux @lalouxlab.bsky.social · 16/07/2025We wrote 2 📕 chapters with tips & tricks to identify protein-protein interactions in bacteria 🦠 1) In vivo proximity labeling with miniTurbo link.springer.com/protocol/10.... 2) An adapted polar recruitment assay feat. E. coli as a test tube link.springer.com/protocol/10..... Enjoy #MicroSky 🧪media.tenor.coma man wearing sunglasses and a white t-shirt is holding something in his hands .ALT: a man wearing sunglasses and a white t-shirt is holding something in his hands . 14015
Reposted by Géraldine LalouxYves Brun lab @brunlabcaulo.bsky.social · 09/07/2025Please repost: PhD position with my lab and @weisslab.bsky.social in a great collaboration on bacterial adhesion #microsky. See drive.google.com/file/d/1GJD4... 11314
Reposted by Géraldine LalouxTung Le @tunglejic.bsky.social · 09/05/20251/ Excited to share our latest work on gene transfer agents (GTAs) in Caulobacter crescentus, led by Emma Banks in collaboration with Pavol Bardy and Mai Nguyen from York!!! See a brief thread below. shorturl.at/o6S1wshorturl.atA bacterial CARD-NLR immune system controls the release of gene transfer agentsBacteria have evolved a wide array of immune systems to detect and defend against external threats including mobile genetic elements (MGEs) such as bacteriophages, plasmids, and transposons. MGEs are ... 28738
Reposted by Géraldine LalouxMartin Thanbichler @thanbichlerlab.bsky.social · 02/04/2025#Postdoc position - at the University of Marburg (Germany), funded within our ERC Advanced Grant "C-SWITCH" Focus: CTP-dependent molecular switches as a new principle of cellular regulation in bacteria (including bacteriophages) Apply by 04 May: stellenangebote.uni-marburg.de/jobposting/2... 13834
Reposted by Géraldine Lalouxmosorio91.bsky.social @mosorio91.bsky.social · 15/03/2025I’m very happy to share our latest work on the ParABS system. We investigated the dynamic interaction between the ATPase ParA and the CTPase ParB mediating chromosome segregation in Myxococcus xanthus. I would like to thank all the people involved. 22715
Reposted by Géraldine LalouxYves Brun lab @brunlabcaulo.bsky.social · 12/03/2025Please repost: Postdoc position in antibiotic discovery in a large multidisciplinary project combining high-throughput approaches, microscopy, AI, and hit-to-lead optimization at @umontreal.ca and @mila-quebec.bsky.social. Apply to ML.Antibiotics@gmail.com. See lnkd.in/dVVk4N3s. #microsky 179112
Reposted by Géraldine LalouxDame lab at Leiden University @damelab.bsky.social · 20/02/2025In @molecularmicro.bsky.social: two special issues on Prokaryotic Chromosome Organization. Many excellent contributions, including a vision article: 'Future directions of the Prokaryotic Chromosome Field', outcome of BioPhyChrom 2023 @biophychrom.bsky.social onlinelibrary.wiley.com/doi/10.1111/...onlinelibrary.wiley.comFuture Directions of the Prokaryotic Chromosome FieldIn September 2023, the Biology and Physics of Prokaryotic Chromosomes meeting ran at the Lorentz Center in Leiden, The Netherlands. As part of the workshop, those in attendance developed a series of .... 23225
Géraldine Laloux @lalouxlab.bsky.social · 04/12/2024A million thanks to the ERC for the opportunity to explore bacterial predatory attacks and cell cycle switches with our VAMPIRE Consolidator grant @deDuveInstitute @UCLouvain_be @frsFNRS 🦠 🔬 🧛 18986
Reposted by Géraldine LalouxYves Brun lab @brunlabcaulo.bsky.social · 13/11/20242 days left. Asst/Assoc Prof position in bacteriology, Université de Montréal. Deadline ***Nov. 15*** come join our growing community of bacteriologists. BTW Canada is the USA’s Bluesky! 11828
Reposted by Géraldine LalouxEduardo Rocha @epcrocha.bsky.social · 04/04/2024New job offer: we search a postdoc (bioinformatics) to work on mobile genetic elements and gene flow in bacteria, with a focus on antibiotic resistance within a consortium including bioinformatics, synthetic biology, epidemiology & biochemistry. See research.pasteur.fr/en/job/postd... #MicroSky 02437
Géraldine Laloux @lalouxlab.bsky.social · 14/03/2024Former PhD student Ophélie Remy and I are cell poles enthusiasts, so we were delighted to offer a brief perspective on bacterial polarity for the Special Issue on Cell and tissue polarity in the Journal of Cell Science. journals.biologists.com/jcs/article-.... #MicroSky 030
Géraldine Laloux @lalouxlab.bsky.social · 13/03/2024Our last story on cell polarity in Bdellovibrio bacteriovorus is now published in Journal of Bacteriology! Feat. a protein that marks the "head" of future daughter cells before non-binary division, a new DivIVA pattern, and 1st use of proximity labeling in Bdello! journals.asm.org/doi/10.1128/... 051
Reposted by Géraldine LalouxSTCmicrobeblog @stcmicrobeblog.bsky.social · 02/02/2024cell divisionist take note 👇 meetings.embo.org/event/24-z-r...meetings.embo.orgArchaeal and bacterial cell division: Beyond the Z-ringThe objective of this EMBO Workshop is to discuss advances in prokaryotic cell division. Most archaea and bacteria divide using a ring-structure formed by the tubulin homologue FtsZ, the Z-ring. Rese�... 075
Reposted by Géraldine LalouxDaniela Barillà @danielabarilla.bsky.social · 03/12/2023MRC- funded PhD project at the interface between biology & physics to investigate the segregation of an antibiotic resistant plasmid. Interdisciplinary training with super supportive supervisors. In the beautiful historic city of York. Please re-post, thanks! #microsky 🦠🧫🧪 📆17 December 0813