Abstract. The formation of DNA double-strand breaks (DSBs) by Spo11 is tied to the loop-axis organization of meiotic chromosomes. Before DSB formation, chr

Accurate chromosome segregation requires bipolar kinetochore-microtubule attachments. Error correction mechanisms promote cycles of kinetochore-microtubule release and reattachment until bipolar attac...

University of California, San Francisco Online Faculty Recruitment

UNIVERSITY OF MICHIGAN FACULTY POSITION IN CELL & MOLECULAR BIOLOGY AND RELATED FIELDS   The Department of Molecular, Cellular, and Developmental B...

The American Society for Cell Biology (ASCB) and its research journal, Molecular Biology of the Cell (MBoC), are proud to recognize the outstanding scientific achievements of early career researchers ...

In this review, we discuss three meiotic checkpoints—the DNA damage response, the pachytene checkpoint, and the spindle checkpoint—and highlight their similarities and differences across diverse syste...

Did you know that 21st March is World Down Syndrome Day? Learn why this official day exists and what it is about.

ASCB’s mission is to lead a diverse, global and multidisciplinary scientific community focused on the cell, the basic unit of all life. Executive Committee Council Members Committee Chairs Editors In ...

Nature Cell Biology - Programmes that support diversity, equity and inclusion (DEI) in science are under attack in the USA. Data indicate that diversity in the scientific workforce increases...

Mammalian female meiosis is uniquely regulated to produce a developmentally competent egg capable of supporting embryogenesis. During meiosis I, homologous chromosomes segregate, with half extruded in...