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Mo. Elrggal

@kidneyman.bsky.social
735 followers 1.5K following 49 posts

Nephrologist, 🇪🇬, Father, NSMC, NephJC, ISNACT, ISNGTF, NDTsocial, PLOSONE, ESNT, JHAH

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Mo. Elrggal @kidneyman.bsky.social · 20/12/2025
CKD prevalence in elderly and the eGFR inflation effect, a very important paper in the @ndt-era.bsky.social . Not just for elderly but also for the young CKD population academic.oup.com/ndt/article/... #nephinp #nephrology_in_practice
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Mo. Elrggal @kidneyman.bsky.social · 13/12/2025
A must read comprehensive article @ndt-era.bsky.social focusing on the biology/genetics of kidney stone. It highlights GWASs of calcium and phosphate handling (e.g., SLC34A1, CYP24A1, CaSR) and crystallization inhibitors (e.g., UMOD, pyrophosphate-related genes). academic.oup.com/ndt/article-...
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 06/11/2025
large cohort study of CDK 4/6 BRAF EGFR VEGF and other cancer treatments #OncoNephrology #NephSky #KidneyWk jamanetwork.com/journals/jam... from Shuchi Anand et al from @stanfordmedicine.bsky.social
The subdistribution hazard ratios for progressive kidney dysfunction are shown for each drug group compared with their respective propensity score–matched cohort. The blue dots represent the hazard ratio and 95% CIs. Due to wide confidence intervals, MET inhibitors results reported in the text and not displayed here. MET inhibitors are included in overall treated group. Model is adjusted for hypertension, diabetes, ischemic heart disease, congestive heart failure, chronic obstructive pulmonary disease, cirrhosis, age, sex, race, body mass index, and eGFR before drug start. ALK indicates anaplastic lymphoma kinase; BRAF, B-Raf proto-oncogene, serine/threonine kinase; CDK4/6, cyclin dependent kinase 4 or 6; EGFR, endothelial growth factor receptor; ERBB2, human epidermal growth factor receptor 2; PARP, poly(adenosine diphosphate-ribose) polymerase; VEGFR, vascular endothelial growth factor receptor.
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ASN Publications @asnpublications.bsky.social · 07/11/2025
Now live in #ASNJASN, simultaneously published with #KidneyWk: "Immunosuppression in Older Kidney Transplant Recipients: A Randomized Controlled Trial" Read more: kidney.pub/JASN0924
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JAMA @jama.com · 07/11/2025
Among more than 800 000 CKD-PC participants, discordance between cystatin C and creatinine eGFR values was associated with increased risk of death, cardiovascular events, and kidney failure. #KidneyWK @asnkidney.bsky.social ja.ma/4oV4DtU
JAMA graph shows association of eGFR difference with risks of long-term adverse outcomes. Hazard ratio vs. difference between eGFRcys & eGFRcr (%). Lines for death, CVD death, heart failure, ASCVD, KFRT are plotted. Declining risk as difference approaches zero.
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American Journal of Kidney Diseases @ajkd.bsky.social · 07/11/2025
In celebration of #KidneyWk, the entire November issue is FREE to access until November 30, 2025! Check out the plain-language summaries on what inspired each study, the basic approach taken, what was learned, and why it matters: bit.ly/3X1XpZj
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Cristina Popa @nephroseeker.medsky.social · 06/09/2025
Thoughtful and controversial blog from Last Month in Nephrology #NephSky #MedSy Albuminuria as an ESKD surrogate may be a statistical mirage, limited by imprecision and overinterpretation However, it moved nephrology forward and made studies happen lastmonthinnephrology.wordpress.com
lastmonthinnephrology.wordpress.com
Last Month in Nephrology
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Nephrology Journal Club @nephjc.bsky.social · 06/09/2025
🤔 How often is end-stage kidney disease in patients with MCD/ FSGS? #NephSky #MedSky @brianrifkin.bsky.social dissected the conclusions from the RaDar study in this #NephJCshorts *the original article from @asnpublications.bsky.social www.nephjc.com/news/nephjc-...
nephjc.com
NephJC Shorts: MCD and FSGS Outcomes — NephJC
A NephJC Shorts discussion of the long term data on kidney failure in FSGS and MCD
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Nephrology Journal Club @nephjc.bsky.social · 21/07/2025
On 7/22/25 at 9pm EST only on Bluesky! #NephSky #MedSky join us for a lively discussion. We're debating eGFRdiff (the gap that is sometimes present between the eGFR of cystatin C and creatinine). What does it mean, what causes it and what you should do about it. #NephJC www.nephjc.com/news/egfrdiff
nephjc.com
Mind The Gap: When eGFR Creatinine and Cystatin C Disagree — NephJC
This week, we will discuss the clinical significance of eGFRdiff, the difference in eGFRcys (cystatin C) and eGFRcr (creatinine).
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Mo. Elrggal @kidneyman.bsky.social · 14/07/2025
Read this piece from the ERAKI working group at the @ndt-era.bsky.social regarding the results of the DEFENDER trial published last August @jama.com academic.oup.com/ndt/article/...
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 02/07/2025
We don’t get to discuss every important study that comes out on #NephJC Hence #NephJCShorts www.nephjc.com/news/nephjc-...
nephjc.com
Introducing NephJC Shorts — NephJC
In just over a decade of critical appraisal on NephJC, we have done several experiments. Some of them have worked out phenomenally well, such as the Freely Filtered podcast. Others were not ready for ...
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ISNkidneycare @theisn.org · 03/07/2025
Enjoy the latest edition of ISN-ACT Global Trials Focus (GTF), a monthly list identifying and summarizing recent interesting trials relevant to kidney disease. Each trial is reviewed in context and assessed for its risk of bias in key areas ➡ lite.spr.ly/6...
lite.spr.ly
Clinical Trials (ISN-ACT) - International Society of Nephrology
The ISN-Advancing Clinical Trials (ISN-ACT) is an ISN initiative to encourage existing infrastructures within ISN to improve the global nephrology community’s participation in clinical trial research.
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American Journal of Kidney Diseases @ajkd.bsky.social · 03/07/2025
On the #AJKDBlog, catch up on these interviews with: - Oshozimhede E. Iyalomhe on statin use in CKD - Roger Rodby and William Whittier about renal tubular acidoses - Subhash Chander on urea as a tool for managing SIADH-induced hyponatremia bit.ly/3ztk4VV (FREE)
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UW Nephrology @uwnephrology.bsky.social · 09/05/2025
Dr. Katherine Tuttle focuses her educational Grand Rounds talk on a reemerging topic: "New Approaches to Blocking #Aldosterone & #Angiotensinogen for #Hypertension or #CKD." #kidney #nephrology #nephsky @uwmedicine.bsky.social youtu.be/TeWkmCopuzk
youtu.be
Kathy Tuttle, MD - New Approaches to Blocking Aldosterone & Angiotensinogen for Hypertension or CKD
YouTube video by University of Washington Division of Nephrology
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 09/05/2025
When @rajmehrotra.bsky.social is giving a talk on the factors for home dialysis stagnation and growth in US at the #CSNAGM We get to see a CJASN abstract! From Divya Bajpai
Visual Abstract
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American Society of Diagnostic and Interventional Nephrology @asdinnews.bsky.social · 09/05/2025
📣 Reminder! ASDIN is accepting applications for the $25K Research Grant in Vascular Access — but don’t wait! 🗓 Applications close July 15, 2025. Click here to learn more: www.asdin.org/news/699844/... #vascularaccess #ASDIN #researchgrant #nephrology
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Edgar V. Lerma 🇵🇭 @edgarvlermamd.medsky.network · 09/05/2025
Use of SGLT2 inhibitors (SGLT2i) in ADPKD is not "presently" recommended, because people with ADPKD have been excluded from the clinical trials; thus, its safety has not been evaluated (from @kdigo.org) #Nephpearls #NephSky 👉 kdigo.org/guidelines/a...
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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 10/05/2025
Finerenone reduced kidney and cardiovascular events in CKD and T2D patients, regardless of frailty. Benefits included lower albuminuria and slower eGFR decline, supporting its use even in frail individuals. #podocytetalk #Nephpearls #Nephrology #CKD journals.lww.com/cjasn/abstra...
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Nephrology Times @nephtimes.bsky.social · 08/05/2025
Sparsentan is now approved for the treatment of IgAN in European Union countries. #igan #iganephropathy #kidneydisease #nephrology #nephsky www.docwirenews.com/post/eu-appr...
docwirenews.com
EU Approves Sparsentan for Treatment of IgAN | Docwire News
The European Commission has granted standard approval to sparsentan for the treatment of adults with primary IgA nephropathy (IgAN).
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International Society of Renal Nutrition and Metabolism @isrnm-social.bsky.social · 09/05/2025
SGLT2 Inhibitors and Risk for Hyperkalemia Among Individuals Receiving RAAS Inhibitors jamanetwork.com/journals/jam...
jamanetwork.com
SGLT2 Inhibitors and Risk for Hyperkalemia Among Individuals Receiving RAAS Inhibitors
This cohort study evaluates the association between sodium-glucose cotransporter 2 inhibitors and hyperkalemia in individuals with diabetes, heart failure, or chronic kidney disease receiving renin-an...
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Edgar V. Lerma 🇵🇭 @edgarvlermamd.medsky.network · 09/05/2025
Do you prescribe SGLT2 inhibitors (SGLT2i) for patients with ADPKD? #Nephpearls #AskRenal #NephSky ❤️ LIKE for YES (and why?) ❌ X for NO (and why?) 👉 pubmed.ncbi.nlm.nih.gov/39099568/
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Mo. Elrggal @kidneyman.bsky.social · 07/05/2025
Do you allow hemodialysis patients with permanent HD catheters to shower? Yes No Other, please state www.ajkd.org/article/S027... #nephinp #nephrology_in_practice @ajkd.bsky.social
ajkd.org
Patient and Health Care Provider Perspectives on Showering for Patients With Hemodialysis Central Venous Catheters: A Survey Study
Patients on hemodialysis using a central venous catheter (CVC) are often advised not to shower due to infection risk. This study assessed practices and attitudes of patients and health care providers ...
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Kidney International @kidneyint.bsky.social · 07/05/2025
Progress, challenges, and pragmatic concessions in predicting relative risk of kidney survival in ARPKD doi.org/10.1016/j.kint.2025.02.018 Original article: doi.org/10.1016/j.kint.2025.01.023 #KICommentary #MedSky #NephSky #polycystickidneydisease
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Maddalena Marasà @madmarasa.bsky.social · 07/05/2025
Alternative complement pathway dysregulation in CKD and CKD progression, endothelial inflammation and cardiovascular outcomes… room for complement inhibitors beyond complement-mediated kidney diseases? www.jci.org/articles/vie... #NephSky #MedSky
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American Journal of Kidney Diseases @ajkd.bsky.social · 07/05/2025
Editorial by Harshil A. Fichadiya and John C. Lieske: Do Topiramate and Zonisamide Cause Kidney Stones? bit.ly/FichadiyaED25 (FREE)
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Kidney International @kidneyint.bsky.social · 07/05/2025
#KIControversies in Nephrology Clinical utility of donor-derived cell-free DNA 🧬testing for kidney transplant monitoring in selected patients You can read the ✅Point ✅Counterpoint ✅Editor's summary in the May issue of KI doi.org/10.1016/j.kint.2025.01.039 #MedSky #NephSky #kidneytransplant
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Mo. Elrggal @kidneyman.bsky.social · 03/05/2025
When to use spironolactone, eplerenone or finerenone in the spectrum of cardiorenal diseases academic.oup.com/ndt/article/... An amazing article from the high impact articles published by @ndt-era.bsky.social
academic.oup.com
When to use spironolactone, eplerenone or finerenone in the spectrum of cardiorenal diseases
ABSTRACT. Kidney disease frequently coexists with cardiovascular (CV) diseases, and this dual presence significantly amplifies the risk of adverse clinical
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American Journal of Kidney Diseases @ajkd.bsky.social · 19/04/2025
Stopping Versus Continuing Metformin in Patients With Advanced CKD: A Nationwide Scottish Target Trial Emulation Study bit.ly/3ZdrYxb #OpenAccess #VisualAbstract #CKD
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Mo. Elrggal @kidneyman.bsky.social · 07/04/2025
#nephsky
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Mo. Elrggal @kidneyman.bsky.social · 07/04/2025
Despite my ranking, I am still getting both winners at the finals.. @nephmadness.bsky.social
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 02/04/2025
And I did that in 2016 in response to Dr Rodby’s decisions Funnily, today he agrees with me over on Xitter that this was a giant #BlueRibbonFail #NephMadness
Rodby’s tweet
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 02/04/2025
What is the impact of retracted studies being cited in systematic reviews? Cool study in @jama.com IM jamanetwork.com/journals/jam... Even cooler: ‘feet of clay’ detector from @gcabanac.cpesr.fr used here dbrech.irit.fr/pls/apex/f?p... #MedSky #EpiSky
jamanetwork.com
Inclusion of Retracted Studies in Systematic Reviews and Meta-Analyses of Interventions
This systematic review and meta-analysis identifies reports of systematic reviews that included retracted studies in their meta-analyses, and assesses the impact of these retracted studies on the resu...
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ASN Publications @asnpublications.bsky.social · 01/04/2025
The April issue of JASN is now available online! Topics covered this month include: - Novel Therapies for IgA Nephropathy - Rituximab in Podocytopathies - and more Find the issue here: journals.lww.com/jas... #ASNJASN
JASN April 2025 issue
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Mo. Elrggal @kidneyman.bsky.social · 02/04/2025
Results of the first round are up @nephmadness.bsky.social #nephsky Excellent results for @nephsim.bsky.social 8/8
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Mo. Elrggal @kidneyman.bsky.social · 28/03/2025
Check my latest editorial @kidney360 journals.lww.com/kidney360/fu...
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Edgar V. Lerma 🇵🇭 @edgarvlermamd.medsky.network · 26/03/2025
What other Landmark Trials in ADPKD should be included in this list⁉️ #Nephpearls #NephJC #NephSky ⏹️ CRISP pubmed.ncbi.nlm.nih.gov/16707749/ ⏹️ Everolimus pubmed.ncbi.nlm.nih.gov/20581392/ ⏹️ TEMPO 3:4 pubmed.ncbi.nlm.nih.gov/23121377/ ⏹️ HALT A pubmed.ncbi.nlm.nih.gov/25399733/ ⏹️ HALT B ⏹️ REPRISE
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ASN Publications @asnpublications.bsky.social · 25/03/2025
The ASN Journal Portfolio seeks early career scientists and junior faculty members interested in participating in the editorial process of peer reviewed journals to join our Junior Associate Editor (JAE) Program. Learn more and apply by May 2. bit.ly/TraineePrograms @rajmehrotra.bsky.social
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Nephrology Times @nephtimes.bsky.social · 25/03/2025
Trials of #SGLT2 inhibitors dapagliflozin and empagliflozin have shown renal benefits, but those trials excluded patients with #ADPKD. #nephrology #nephsky #kidneydisease
docwirenews.com
Dapagliflozin With Tolvaptan May Have Additive Effect in Slowing ADPKD Progression | Docwire News
A study examined the effects of adding dapagliflozin to treatment with tolvaptan in patients with autosomal dominant polycystic kidney disease (ADPKD).
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KDIGO @kdigo.org · 25/03/2025
The draft Scope of Work for the KDIGO 2025 B Cell–Mediated Therapies Controversies Conference is open for public comment through April 21. Download the SOW and submit feedback via the form on the conference site: kdigo.org/conferences/... #BCell
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Nephrology Times @nephtimes.bsky.social · 24/03/2025
⚠️ The FDA has approved oral iptacopan to treat proteinuria in adults with C3 glomerulopathy. This is the first FDA-approved treatment for C3G. #fda #c3glomerulopathy #c3g #kidneydisease #nephrology #nephsky
docwirenews.com
Iptacopan Becomes First Approved Therapy for C3G | Docwire News
Oral iptacopan (Fabhalta) has become the first FDA-approved treatment for proteinuria in adults with C3 glomerulopathy (C3G).
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Nephrology Journal Club @nephjc.bsky.social · 24/03/2025
Happening this week! The @kdigo.org guidelines in #ADPKD #PKD on #NephJC www.nephjc.com/news/adpkd-k... Summary from @brianrifkin.bsky.social
nephjc.com
KDIGO 2025 ADPKD Guidelines Review — NephJC
This week, we will discuss the first iteration of KDIGO’s 2025 guidelines on ADPKD.  These guidelines are a result of a decade of global collaboration between physicians, researchers, advocates, ...
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Mo. Elrggal @kidneyman.bsky.social · 22/03/2025
A new trial published @ndt-era.bsky.social assessing a new device integrated in the PD cycler for remote monitoring of automated PD, whether it will improve clinical outcomes or not.
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Mo. Elrggal @kidneyman.bsky.social · 22/03/2025
#nephsky
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Mo. Elrggal @kidneyman.bsky.social · 22/03/2025
#nephsky
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Mo. Elrggal @kidneyman.bsky.social · 22/03/2025
#nephsky
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Mo. Elrggal @kidneyman.bsky.social · 22/03/2025
Still anyone thinking #denervation will do better than #noveantiHTNmedications?! in the first round of @nephmadness.bsky.social #trashtalks #nephmadness #Noveltreatments FTW!
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Mo. Elrggal @kidneyman.bsky.social · 22/03/2025
I am "CONVINCE"D that #hemodiafiltration will overcome #incrementalhemodialysis in the @nephmadness.bsky.social match on the first round. you will be lost if you chose #incrementalHD #trashtalk #nephmadness or may be the #blueribbonfail are not yet "CONVINVE"D !!
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Amy Wieckowski @amywski.bsky.social · 21/03/2025
Thanks for the tip off @robertbrownpharm.bsky.social - sharing for any others who might find this useful #pharmsky #nephsky #medsky
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 20/03/2025
we have reached the point where we seriously should avoid travelling to the US Sorry @asnkidney.bsky.social @ahascience.bsky.social @kidneycon.bsky.social #NephSky
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 20/03/2025
Nice blurb in @asnkidney.bsky.social in the loop about the CRRT curriculum in @ajkd.bsky.social Free link (few more weeks, download now) authors.elsevier.com/sd/article/S... Thanks to @nephcrit.bsky.social & Ted Clark for helming this & @melhoenig.bsky.social for the invite! #NephSky #Free
Continuous Kidney Replacement Therapies: Core Curriculum 2025

Continuous kidney replacement therapy (CKRT) has largely become the standard of care in developed nations for the treatment of acute kidney injury in patients with shock, acute brain injury, acute liver failure, and other forms of critical illness. A Core Curriculum article in the American Journal of Kidney Diseases reviews the physicochemical principles of CKRT, describes when and how to prescribe CKRT, and summarizes trials that serve as the foundation for approaches to initiation timing, dosing, vascular access, and anticoagulation for CKRT. The authors highlight components of high-value multidisciplinary care for patients receiving CKRT, including drug dosing, nutrition, physical rehabilitation, and CKRT quality assurance programs.
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