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Maddalena Marasà

@madmarasa.bsky.social
81 followers 112 following 18 posts

Nephrologist, Clinical Research Center for Rare Diseases "Aldo e Cele Daccò", Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy Opinions are my own #kidneydisease #raredisease #genetics #glomerulardisease

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Maddalena Marasà @madmarasa.bsky.social · 14/04/2026
Another fantastic milestone for rare glomerular diseases! What an impressive momentum in kidney therapeutics and the rare disease community #raredisease #glomerulardisease #nephSky #FSGS
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International Society of Glomerular Disease @isgd.bsky.social · 25/09/2025
Today is #C3GAwarenessDay! At ISGD, we stand with people living with this rare kidney disease. As a medical society for #GlomerularDisease experts, we're committed to raising awareness and moving the science forward to bring more hope and solutions to the C3G community. #C3G #ISGD
Dark Teal background with white circle in middle with yellow border. In the circle it says C3G Awareness Day. Under the circle there is a hashtag #C3GAwarenessDay, and the text Every rare kidney disease deserves to be seen.
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Maddalena Marasà @madmarasa.bsky.social · 31/08/2025
This is so shameful…
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Simone Sanna-Cherchi 🧬 @genetickidneydoc.bsky.social · 07/08/2025
Fresh online on @natcomms.nature.com ! Great collaboration with the lead team at GharaviLab / CPMG. Large exome-wide analysis that points to many findings, including two novel genes: ARID3A and NR6A1. #CAKUT #humangenetics #development #pediatrics #NephSky #SkyNeph www.nature.com/articles/s41...
nature.com
Exome analysis links kidney malformations to developmental disorders and reveals causal genes - Nature Communications
The authors analyze rare coding variants in 1990 individuals with congenital kidney anomalies, finding diagnostic variants in 14.1% of cases. They identify two new causal genes, ARID3A and NR6A1, alon...
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Maddalena Marasà @madmarasa.bsky.social · 02/08/2025
Wow! Second approved drug for an ultrarare disease in a few months, and with broader indication. What a milestone! Time for EMA’s approval now. #raredisease #glomerulardisease #c3g #nephSky
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Maddalena Marasà @madmarasa.bsky.social · 14/07/2025
Very remarkable long-term outcomes and safety profile for one of the first mAbs ever used in glomerular diseases #glomerulardiseases #rarediseases #nephSky
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Kidney International @kidneyint.bsky.social · 14/07/2025
To do or not to do—genetic testing for autosomal dominant polycystic kidney disease in children and adolescents doi.org/10.1016/j.kint.2025.05.001 Original article: doi.org/10.1016/j.kint.2025.02.026 #KICommentary #NephSky #MedSky #ADPKD
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The New Yorker @newyorker.com · 14/07/2025
Today’s Daily Cartoon, by Paul Noth. #NewYorkerCartoons Sign up for our humor newsletter to never miss a Daily Cartoon: nyer.cm/kyxchAh
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Nick Kristof @nickkristof.bsky.social · 22/06/2025
President Trump claims the US strike on Iran was a "spectacular military success." We'll see. What we do know is that Trump has pushed the US into a new war in the Middle East with considerable risks of escalation. Here are the risks I'm concerned about: www.nytimes.com/2025/06/22/o...
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Maddalena Marasà @madmarasa.bsky.social · 23/05/2025
Kidney health finally prioritized in the WHO noncommunicable disease agenda! #kidneyhealthmatters #nephsky #medsky
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Columbia Department of Medicine @cuimcmedicinedept.bsky.social · 22/05/2025
In a new publication, Drs. Steers, Gharavi and colleagues performed genetic and immunological studies of IgA nephropathy and demonstrated a new role of aberrant O-glycosylation in the pathogenesis of IgA Nephropathy. Read more here: www.jci.org/articles/vie...
jci.org
JCI - Loss of GalNAc-T14 links O-glycosylation defects to alterations in B cell homing in IgA nephropathy
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Maddalena Marasà @madmarasa.bsky.social · 20/05/2025
Increased risk of developing #kidneydisease in offspring exposed to maternal preeclampsia independently from preterm birth? #nephsky #medsky
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Maddalena Marasà @madmarasa.bsky.social · 14/05/2025
Scientific progress grows out of freedom. As a society, we must stand with scientists and speak out against restrictions on scientific freedom and funding - we are all in this together. www.nature.com/articles/d41... www.science.org/content/arti...
nature.com
US researchers must stand up to protect freedoms, not just funding
Curtailment of freedoms and disregard for the rule of law in the United States is destroying the ability of science to serve the nation’s, and the world’s, interests. Researchers can take action.
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Maddalena Marasà @madmarasa.bsky.social · 07/05/2025
Alternative complement pathway dysregulation in CKD and CKD progression, endothelial inflammation and cardiovascular outcomes… room for complement inhibitors beyond complement-mediated kidney diseases? www.jci.org/articles/vie... #NephSky #MedSky
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Jarcy Zee @jarcyzphd.bsky.social · 24/04/2025
Hey I know these people! Check out this paper👇
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Science Magazine @science.org · 30/04/2025
After Trump’s first 100 days, agency scientists say U.S. health institutes are demoralized and have lost essential staff and funding.
scim.ag
NIH insiders: Trump is ‘dismantling and destroying everything'
After just 100 days, agency scientists say U.S. health institutes are demoralized and have lost essential staff and funding
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Maddalena Marasà @madmarasa.bsky.social · 01/05/2025
100-day mark and 1361 to go… www.nytimes.com/interactive/...
nytimes.com
How Trump’s Second Term Is Changing Power, Institutions and More (Gift Article)
President Trump has wielded the presidency as an instrument of blunt power, ignoring the howls of outrage from Democrats and daring largely docile Republicans to challenge the limits of his authority.
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Maddalena Marasà @madmarasa.bsky.social · 06/04/2025
#handsoff
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Lisa Jarvis @lisamjarvis.bsky.social · 03/04/2025
Public health, biomedical science, and the well being of Americans will be worse off for this week's devastating cuts at HHS. My latest for @opinion.bloomberg.com (gift link):
bloomberg.com
This Isn’t How You Make America Healthy Again
Gutting the public health agencies that keep Americans safe — and not being transparent about it — will cause harm that can’t easily be reversed.
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Maddalena Marasà @madmarasa.bsky.social · 01/04/2025
"The strategy of not speaking up out of fear is not working" @lisamjarvis.bsky.social calls Big pharma to mobilize and support federally funded research and drug evaluation - both engines of most innovation biotech and pharma companies develop.
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Krzysztof Kiryluk @kirylukk.bsky.social · 31/03/2025
Finally, top scientists speak up against the Trump administration in a letter signed by 2,000 elected members of the National Academies of Sciences, Engineering, and Medicine: "the nation's scientific enterprise is being decimated"; see related NYT coverage here: www.nytimes.com/2025/03/31/s...
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Cravedi Lab @cravedilab.bsky.social · 29/03/2025
Beautiful, mechanistic work! Loss of GalNAc-T14 links O-glycosylation defects to alterations in B cell homing in IgA nephropathy www.jci.org/articles/vie...
jci.org
JCI - Loss of GalNAc-T14 links O-glycosylation defects to alterations in B cell homing in IgA nephropathy
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Cravedi Lab @cravedilab.bsky.social · 25/03/2025
Transplantation of human kidney organoids elicited a robust allogeneic response in a humanized mouse model. www.sciencedirect.com/science/arti...
sciencedirect.com
Transplantation of human kidney organoids elicited a robust allogeneic response in a humanized mouse model.
Human kidney organoids derived from embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) have become novel tools for studying various…
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Maddalena Marasà @madmarasa.bsky.social · 24/03/2025
Columbia's "IgA Nephropathy Diagnosis & Treatment Updates 2025" on April 4th. All the latest IgAN updates in one place with outstanding speakers! @cuimcglomcenter.bsky.social @cuimcmedicinedept.bsky.social @jradnephro.bsky.social @kirylukk.bsky.social #Nephsky #glomerulardisease
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The Lancet Public Health @thelancetph.bsky.social · 21/03/2025
NEW editorial on what public health means under Trump 2.0 At The Lancet Public Health, it still means to stand for the communities we serve, to report, document, support researchers and practitioners, and advocate for better health for ALL. Read #openaccess www.thelancet.com/journals/lan...
thelancet.com
Public health under Trump 2.0: the first 50 days
Jan 20, 2025, US President Donald Trump took charge of the Oval Office and began by signing an array of executive orders spanning from withdrawal from WHO and the Paris Climate Agreement to freezing t...
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NEJM.org @nejm.org · 18/03/2025
What is the impact of microplastics on human health? The latest episode of Beyond Journal Club, a collaboration between @coreimpodcast.bsky.social and NEJM Group, takes a deep dive into the APAChE study on microplastics and cardiovascular disease. 🎧 Listen here: nej.md/4igpJQy #MedSky
An illustration of the APAChE study results
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Maddalena Marasà @madmarasa.bsky.social · 18/03/2025
How collection of broad family history from CKD patients improve clinical risk stratification. Proud to be part of this. Thanks to Francesca Zanoni, @kirylukk.bsky.social #CureGN #CRIC #NephSky
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Krzysztof Kiryluk @kirylukk.bsky.social · 16/03/2025
Nice to see this in print - combined analysis of #CureGN and #CRIC demonstrates the value of broad family history collection from patients with various forms of CKD. Interestingly, positive family history of diabetes was associated with a higher risk of CKD progression even in non-diabetics!
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Kidney International @kidneyint.bsky.social · 17/03/2025
Emerging role of genetics🧬 in #kidneytransplantation doi.org/10.1016/j.kint.2024.09.026 #KIMiniReview #ChronicKidneyDisease #CKD #genetickidneydisease #NephSky #MedSky
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ASN Publications @asnpublications.bsky.social · 17/03/2025
Combined PLA2R-Ab testing with ELISA and IIF provided optimal test characteristics in making a non-invasive diagnosis of MN before or soon after kidney biopsy. Further studies needed to assess whether genetic data can augment this approach. bit.ly/CJASN0671 #ASNCJASN @jarcyzphd.bsky.social
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Maddalena Marasà @madmarasa.bsky.social · 14/03/2025
#WorldKidneyDay reminds of the vital role kidneys play in health #KidneyDisease affects 850+ million people worldwide >70% undiagnosed and untreated #kidneyhealth is a global health priority #EarlyDetection =early protection #CKDAwareness #NephSky #MedSky #AreYourKidneysOK @thelancet.bsky.social
thelancet.com
Kidney disease at the forefront of the global health agenda
World Kidney Day, observed this year on March 13, is a crucial reminder of the vital role kidneys play in health. The 2025 campaign theme, Are Your Kidneys OK? Detect Early, Protect Kidney Health, hig...
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Maddalena Marasà @madmarasa.bsky.social · 11/03/2025
Wondering how they pick which grants to cut… “banned” words maybe?
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Maddalena Marasà @madmarasa.bsky.social · 05/03/2025
One more piece to the anti-nephrin autoantibodies story #nephroticsyndrome #raredisease #glomerulardisease #Nephsky @kidneyint.bsky.social @isgd.bsky.social
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ISNkidneycare @theisn.org · 28/02/2025
Globally, 150+ rare kidney diseases affect 60–80 people per 100,000. Many are hereditary, with inherited kidney disease seen in 10% of adults & most children on #KRT. Yet, barriers to diagnosis & treatment persist, especially in LMICs. On #RareDiseaseDay, we call for action! #KidneyHealthMatters
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Maddalena Marasà @madmarasa.bsky.social · 25/02/2025
Totally agree with @kirylukk.bsky.social
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Magdalena Skipper @magdalenaskipper.bsky.social · 25/02/2025
Great minds… within 24 hrs both us at @nature.com and @science.org make similar appeals to the research community. And @holdenthorp.bsky.social and I didn’t even exchange notes about it ;-) 🧪 www.nature.com/articles/d41... www.science.org/doi/10.1126/...
science.org
Come together, right now
The chaos, conflicting information, firings, and hurtful rhetoric of the Trump administration’s approach to science over the past month are causing anxiety, grief, and concern for the scientific commu...
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Science Magazine @science.org · 11/02/2025
"These [NIH indirect cost reimbursement] cuts should be a rallying cry for higher education to come together to make the case for the American system of research and teaching,” writes @holdenthorp.bsky.social in a new #ScienceEditorial. scim.ag/4b2nv4D
"All disciplines will be affected by these cuts, not just science." - H. Holden Thorp, Editor-in-chief, Science journals
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