iiinova — where your digital self keeps evolving

Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 18/09/2025

🔹 Calcitriol in IgA Nephropathy. 🔹 Finerenone Pooled Outcomes (FINE-HEART analysis). 🔹 Real-World Risk of Kidney Failure vs. Death in Diabetes. #podocytetalk #Nephpearls #Nephrology #CKD youtu.be/EPO_Wf_nz2w

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Episode 32 - Vitamin D, Finerenone & Kidney Failure Risk in Diabetes: New Evidence in CKD Care

YouTube video by Podocyte Talk - Dr. Anass Qasem

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 18/08/2025

In this episode of Podocyte Talk, we delve into three important studies shaping the management of advanced chronic kidney disease (CKD): 🔹 Exercise Before Dialysis 🔹 Cost-Effectiveness of Low-Protein Diets 🔹 Spironolactone in CKD #podocytetalk #Nephpearls #Nephrology #CKD youtu.be/NFMi6Ysez5w

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Episode 30 - Exercise, Diet, and Spironolactone in CKD: What's the Latest?

YouTube video by Podocyte Talk - Dr. Anass Qasem

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 02/08/2025

In Episode 29 of Podocyte Talk, we cover three high-impact studies: Measured GFR After Bariatric Surgery Pregnancy and Long-Term Kidney Function in Chronic Kidney Disease Dapagliflozin and Health-Related Quality of Life #podocytetalk #Nephpearls #Nephrology #CKD youtu.be/yUfhuKXL_-s

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Episode 29 - GFR After Bariatric Surgery, Pregnancy in CKD, and DAPA Quality of Life Benefits

YouTube video by Podocyte Talk - Dr. Anass Qasem

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 15/07/2025

In Episode 28 of Podocyte Talk, we discuss three clinically relevant studies advancing care in nephrology and transplant medicine: Intradialytic Exercise Trial . EVEREST Post-Hoc Analysis. Transplant Infection Study (India). #podocytetalk #Nephpearls #Nephrology #CKD youtu.be/LEh0boi4Ovc

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Episode 28 - Exercise During Dialysis, Kidney Function in Heart Failure, and Transplant Infections

YouTube video by Podocyte Talk - Dr. Anass Qasem

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 01/07/2025

🎙️New #PodocyteTalk! GLP-1 RAs reduce death & boost transplant listing in dialysis. Biomarkers predict CKD outcomes. Sotradecol foam shrinks cysts in ADPKD/ADPLD. 📺 Watch & subscribe—85% of viewers still haven’t! 🔗 youtu.be/GKCeZsl1s2M #nephrology #CKD

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Episode 27 - GLP-1 RAs in Dialysis, Biomarkers in CKD, and Foam Sclerotherapy in Polycystic Disease

YouTube video by Podocyte Talk - Dr. Anass Qasem

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 16/06/2025

🎙️ In Ep. 26 of Podocyte Talk: – Finerenone + empagliflozin: better together in DKD – Hypoglycaemia common post-dialysis in older adults – Tirzepatide lowers albuminuria in obesity, with/without diabetes Listen now! #CKD #Nephrology #Diabetes #GLP1 youtu.be/NiNvQYVdhIw

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Episode 26 - Can We Do More for Diabetic Kidneys?

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 05/06/2025

Dual therapy with finerenone + empagliflozin cut albuminuria by ~30% more than either drug alone in CKD + T2D—with no added safety concerns. A promising step for combo treatment in DKD. #CKD #T2D #SGLT2i #Finerenone #CONFIDENCE #Nephrology #BlueskyMD

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 01/06/2025

Episode 25 of Podocyte Talk is out! 🎧 Albuminuria predicts AF in the elderly 💉 Rituximab shows >95% 10-yr renal survival in MN 🫁 Pre-KTx pulmonary HTN = higher graft loss Smart nephrology insights you can use. #CKD #Nephrology #Podcasts youtu.be/EO0eLgu6uuw

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Episode 25 - Early Albuminuria and AF | Long-Term Rituximab in MN | Pulmonary HTN & Transplant Risk

YouTube video by Podocyte Talk - Dr. Anass Qasem

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 15/05/2025

Podocyte Talk Episode 24: – SGLT2i vs GLP-1RA in real-world CKD care – Finerenone works regardless of early eGFR drop – High-carb diets raise mortality in dialysis patients #Nephrology #KidneyCare #Finerenone #SGLT2i #GLP1RA #podocytetalk #Nephpearls #Nephrology #CKD youtu.be/uMbtbhPYBPc

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Episode 24 - SGLT2i vs GLP-1RA, Finerenone & eGFR Drop, and Carbs in Dialysis

YouTube video by Podocyte Talk - Dr. Anass Qasem

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 11/05/2025

Simultaneous initiation of SGLT2i, RASi, ns-MRA, and GLP1-RAs presents a promising approach to mitigate the risk of CV events and the progression of kidney disease in patients with CKD. #podocytetalk #Nephpearls #Nephrology #CKD journals.lww.com/jasn/abstrac...

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 10/05/2025

Finerenone reduced kidney and cardiovascular events in CKD and T2D patients, regardless of frailty. Benefits included lower albuminuria and slower eGFR decline, supporting its use even in frail individuals. #podocytetalk #Nephpearls #Nephrology #CKD journals.lww.com/cjasn/abstra...

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 05/05/2025

In a diverse IgAN cohort, 36% reached kidney failure, major eGFR decline, or died within 2.7 years. Proteinuria ≥0.5 g/g strongly predicted poor outcomes, challenging past beliefs that <1 g/g is low risk. #podocytetalk #Nephpearls #Nephrology #CKD #nephsky academic.oup.com/ndt/advance-...

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 04/05/2025

Kidney outcomes were poor in genetic nephrotic syndrome; in FSGS outcomes were strongly associated with proteinuria level. MCD patients had better proteinuria control than FSGS and had better outcomes at each proteinuria level. #podocytetalk #Nephpearls #nephsky journals.lww.com/jasn/abstrac...

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 04/05/2025

In CKD, furosemide use—especially >100 mg/day—is linked to higher serum levels of protein-bound uraemic toxins like IS, PCS, Kyn, and IAA. Furosemide may impair toxin clearance via OAT1/3 transporters, contributing to toxin accumulation. #podoctyetalk #CKD #Nephsky www.kireports.org/article/S246...

kireports.org

Furosemide and Serum Protein-Bound Uraemic Toxin Concentrations in Patients with Chronic Kidney Disease

Furosemide is commonly prescribed to patients with CKD but may impair the kidney’s excretion of protein-bound uraemic toxins (PBUTs) via the organic anion transporters 1 and 3 (OAT1/OAT3). We evaluate...

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 01/05/2025

In Episode 23 of Podocyte Talk, we dive into three important new studies: use of finerenone in IgA nephropathy, incidence and outcomes of acute kidney injury in very old patients, and risk of UTIs with SGLT2 inhibitors #podocytetalk #Nephpearls #Nephrology #CKD #nephsky youtu.be/X5dh2G-FAuI

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Episode 23 - Finerenone in IgA Nephropathy, AKI in the Very Old, and SGLT2i UTI Risks

YouTube video by Podocyte Talk - Dr. Anass Qasem

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 15/04/2025

Podocyte Talk is now twice monthly! Each episode includes 2 multiple-choice questions—answer in the comments and test your nephrology knowledge! In this episode, we explore three impactful studies in nephrology #podocytetalk #Nephpearls #Nephrology #CKD youtu.be/C1MQgOdVdv4

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Episode 22 - Phosphate Binders, Cancer Risk & Early Treatment in CKD – Test Yourself with 2 MCQs

YouTube video by Podocyte Talk - Dr. Anass Qasem

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 01/04/2025

✅ SGLT2 inhibitors in patients with advanced CKD ✅ Anti-nephrin antibodies as relapse predictors in MCD & FSGS ✅ Sacubitril/valsartan improves dialysis access flow in heart failure #podocytetalk #Nephpearls #Nephrology #CKD #nephsky youtu.be/YkNoV6CDmxU

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Episode 21 - Breakthroughs in Kidney Care: SGLT2i in CKD, New Biomarkers, and Better Dialysis Flow

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 28/03/2025

Among low-risk patients undergoing PCI, contrast-associated AKI was rare, and withholding or continuing SGLT2 inhibitors had no impact on AKI risk or renal function. discontinuation in this setting may not be necessary. journals.lww.com/kidney360/pa... #Podocytetalk @asnpublications.bsky.social

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 28/03/2025

This study highlights the negative impact of hypertension early after kidney transplantation and emphasizes the importance of effective treatment to improve long-term graft and patient survival. www.kireports.org/article/S246... #Podocytetalk #nephrology #CKD #Nephsky

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 24/03/2025

BP targets post kidney transplant, SGLT2i use in angiography, and CGM insights in dialysis—all in Ep. 20 of Podocyte Talk. Tune in for key updates in nephrology! 🎧 #Nephrology #KidneyCare #podocytetalk #Nephpearls #nephsky youtu.be/fW2Ug1Sk9Rk

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Episode 20 - BP Target in renal transplant, SGLT2i with contrast, and Glucose Monitoring in Dialysis

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 17/03/2025

This week, we break down three major nephrology studies: ✅ Obinutuzumab’s role in lupus nephritis ✅ Best phosphate binders for dialysis patients ✅ Long-term effects of tolvaptan in ADPKD #podocytetalk #Nephpearls #Nephrology #CKD youtu.be/86pdnfUKlsA

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Episode 19 - Lupus nephritis, Phosphate Binders & Tolvaptan: Key Updates in Nephrology!

YouTube video by Podocyte Talk - Dr. Anass Qasem

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 16/03/2025

A JASN study links higher CKM stages to increased 15-year CV mortality (Stage 0: 5.5%, Stage 4: 15.2%). Stage 4 had a 9.6% higher risk. Early intervention is crucial. journals.lww.com/jasn/pages/a... #Podocytetalk #Nephrology #CKM

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 15/03/2025

Tolvaptan slowed kidney function decline by 14%, reducing eGFR loss over time. However, it did not significantly impact total kidney volume (TKV) growth. Patients with higher osmolar intake showed a greater treatment response #Podocytetalk #nephsky #nephrology academic.oup.com/ndt/advance-...

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The long-term effect of tolvaptan treatment on kidney function and volume in patients with ADPKD

AbstractBackground and hypothesis. The only therapy to ameliorate disease progression in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD)

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 03/03/2025

In this episode of Podocyte Talk, we explore the impact of obesity on polycystic kidney disease progression, the predictive power of albuminuria in IgA nephropathy, and how tacrolimus metabolism affects kidney transplant outcomes #podocytetalk #Nephpearls #Nephrology #CKD youtu.be/cFq0B8kr_ZU

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Episode 18 - Overweight, Albuminuria, and immunosuppression Metabolism in Kidney Disease

YouTube video by Podocyte Talk - Dr. Anass Qasem

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 25/02/2025

High-intensity interval training significantly reduced the risk of rapid eGFR decline in older adults. journals.lww.com/jasn/abstrac... #podocytetalk #Nephpearls #CKD #nephsky

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 24/02/2025

Can exercise slow kidney decline? How does Cardiovascular-Kidney-Metabolic (CKM) syndrome impact long-term survival? And can diuretics be safely used in hepatorenal syndrome? #podocytetalk #Nephpearls #Nephrology #CKD youtu.be/2MgEtM6sh1w

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Episode 17 - Exercise, CKM Syndrome & Hepatorenal Syndrome: Key Insights

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 10/02/2025

Key Breakthroughs in Kidney Disease & Transplantation "Exploring new insights into IgA nephropathy, kidney transplantation in lupus nephritis, and thrombotic microangiopathy post-transplant." #podocytetalk #Nephpearls #Nephrology #CKD #nephsky youtu.be/huUGTkIet04

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Episode 16 - Key Breakthroughs in Kidney Disease & Transplantation

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 04/02/2025

No association was observed between aspirin use and risk of nonfatal atherosclerotic CVD or cardiovascular death in patients with CKD stages G3 and G4 without prior CVD. Aspirin use was associated with higher risk of major bleeding. journals.lww.com/cjasn/abstra... #podocytetalk #CKD #nephsky

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 04/02/2025

In people with non–dialysis-dependent CKD, revascularization may be associated with lower all-cause mortality compared with medical management and may also lower the risk of cardiovascular events. journals.lww.com/cjasn/pages/... #podocytetalk #Nephpearls #CKD #nephsky

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 02/02/2025

These findings support the use of sodium-glucose cotransporter-2 inhibitors in CKD, irrespective of frailty, multimorbidity, or polypharmacy. CJASN 19(9):p 1119-1129, September 2024 #podocytetalk #Nephpearls #CKD #nephsky journals.lww.com/cjasn/fullte...

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 02/02/2025

In this episode, we cover three key studies: ✅ Iron therapy reduces heart failure risk in CKD. ✅ Empagliflozin benefits frail CKD patients. ✅ Long-term outcomes of pancreas-kidney transplants. #podocytetalk #Nephrology #CKD #nephsky youtu.be/WIeE035sYtQ

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Episode 15 - Iron Therapy, SGLT2 Inhibitors & Transplant Outcomes in CKD

YouTube video by Podocyte Talk - Dr. Anass Qasem

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 01/02/2025

In patients with CKD included in this MINT subgroup analysis, a liberal transfusion strategy was not worse than a restrictive transfusion strategy and was associated with less harm in subgroups not receiving dialysis. journals.lww.com/jasn/abstrac... #podocytetalk #Nephpearls #CKD

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 01/02/2025

Greater attention should be given to RV and LA dysfunction for early identification of cardiac dysfunction in CKD patients. Nephrology Dialysis Transplantation 04 October 2024 doi.org/10.1093/ndt/... #podocytetalk #Nephpearls #CKD #nephsky

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 01/02/2025

LYFT updated for older kidney transplant candidates; transplant still better than dialysis (5-year LYFT). Trends slightly declined; needs nuanced metrics for policy. #podocytetalk #Nephpearls #CKD #nephsky

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 26/01/2025

Benefits of haemodiafiltration for vascular access patency, liberal blood transfusion strategies for MI in advanced CKD, and impact of pruritus in dialysis patients with management insights. Tune in for these essential updates! #podocytetalk #Nephpearls #Nephrology #CKD youtu.be/SvCnUG9J1Ww

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Episode 14 - Haemodiafiltration, Transfusion Strategies, and Pruritus in Dialysis Patients

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 19/01/2025

1️⃣ role of hyperkalemia in chronic kidney disease progression and mortality. 2️⃣ impact of glomerular hyperfiltration on cardiovascular disease risks in T2DM. 3️⃣ safety concerns of ondansetron in hemodialysis patients. #podocytetalk #Nephpearls #Nephrology #CKD #nephsky youtu.be/T1o4H4BqfIg

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Episode 13 - Kidney Function, Heart Risks & Medication Safety: New Insights

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 15/01/2025

Vadadustat once daily, but not three times weekly, was noninferior to DA in the correction and maintenance of hemoglobin in patients with dialysis-dependent CKD converted from an ESA. Kidney360 5(11):p 1652-1661, November 2024. | DOI: 10.34067/KID.0000000567 #podocytetalk #nephsky #nephrology

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 15/01/2025

Compared with initiation of antiemetics with lesser QT-prolonging potential, initiation of ondansetron was associated with higher short-term cardiac risks among people receiving hemodialysis. JASN 35(6):p 761-771, June 2024. | DOI: 10.1681/ASN.0000000000000336 #podocytetalk #nephsky #nephrology

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 14/01/2025

Restarting RASi after discontinuation was associated with a lower risk of kidney outcomes and mortality but not related to the incidence of hyperkalemia. Journal of the American Society of Nephrology 35(10):p 1391-1401, October 2024. | DOI: 10.1681/ASN.0000000000000425 #podocytetalk #nephsky

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 14/01/2025

SGLT2 inhibitors (SGLT2i) consistently reduce kidney outcomes across the spectrum of KDIGO classes and UACR levels in individuals with type 2 diabetes (T2D), CKD, & heart failure. Clin J Am Soc Nephrol. 2025 Jan 1;20(1):39-49. doi: 10.2215/CJN.0000000000000568. #podocytetalk #nephsky #nephrology

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · 14/01/2025

SGLT2 inhibitor and GLP-1 RA discontinuation was common and associated with harmful outcomes in adults with CKD. Journal of the American Society of Nephrology 36(1):p 87-98, January 2025. | DOI: 10.1681/ASN.0000000000000477 #podocytetalk #Nephpearls #Nephrology #CKD

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