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Chordoma Foundation Labs

@cflabsresearch.bsky.social
150 followers 582 following 38 posts

Chordoma Foundation's patient driven research laboratory 100% dedicated to accelerating cures for chordoma.

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Chordoma Foundation Labs @cflabsresearch.bsky.social · 22/09/2025
Important new paper from @neurosurgerynm.bsky.social and several collaborators reveals critical features of the chordoma immune landscape and lays the foundation for chordoma patients to benefit from immunotherapy advances. 🧵 academic.oup.com/neuro-oncolo...
academic.oup.com
Integrated Immune Profiling of Chordomas Reveals Spatially Organized Niches and Functional Heterogeneity
AbstractBackground. Chordomas are locally aggressive notochordal tumors with no systemic therapy options. As an ultra-rare cancer type, our understanding o
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Chordoma Foundation Labs @cflabsresearch.bsky.social · 14/08/2025
monitoring the situation as a shipment of precious chordoma samples from our biobank flys to Melbourne for our collaborators in the Firestein lab at @hudsonresearch.bsky.social ✈️ 🇦🇺
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Chordoma Foundation Labs @cflabsresearch.bsky.social · 29/07/2025
Positive results are celebrated, but we think sharing negative results is important too. In case helpful to anyone, here are compounds we tested in vitro in recent months which didn't show substantial activity as single agents or synergy with known active compounds: figshare.com/authors/Chor...
figshare.com
Chordoma Foundation
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Chordoma Foundation Labs @cflabsresearch.bsky.social · 20/06/2025
We’re hiring for a new role on our research team. It'll be an opportunity to advance interesting science, to work in a nimble and empowering environment, and, to make a tangible impact in the lives of patients in urgent need of new treatment options. www.linkedin.com/jobs/view/42...
linkedin.com
Chordoma Foundation hiring Director of Preclinical Research in Durham, NC | LinkedIn
Posted 12:34:07 PM. The Chordoma Foundation is seeking an experienced and high-agency individual to support the…See this and similar jobs on LinkedIn.
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Chordoma Foundation Labs @cflabsresearch.bsky.social · 06/05/2025
The TBXT rs2305089 SNP links the benign notochordal cell tumour and chordoma pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/...
pathsocjournals.onlinelibrary.wiley.com
The TBXT rs2305089 SNP links the benign notochordal cell tumour and chordoma
The aim of this research was to investigate the pathogenesis of the bone cancer chordoma and the role of the germline rs2305089 SNP in TBXT. Using medical imaging and genotyping studies, we observed ....
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Reposted by Chordoma Foundation Labs
Daniel Alvarez @daninthenet.bsky.social · 04/03/2025
Interesting new challenge similar in spirit to the well known CACHE!!
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Chordoma Foundation Labs @cflabsresearch.bsky.social · 22/02/2025
For all the gains AI affords in compound design and discovery, experimental validation still remains a bottleneck. But we're making that part easy for the cancer target TBXT with a suite of biophysical, in vitro and in vivo assay capabilities—plus prizes for potent binders: tbxtchallenge.org
tbxtchallenge.org
TBXT CHALLENGE – Make history in drug discovery
Make history in drug discovery
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Reposted by Chordoma Foundation Labs
The Institute of Cancer Research @icr.ac.uk · 15/02/2025
📰 Prof Paul Workman, our former CEO, along with his team in our Centre for Cancer Drug Discovery, have made a breakthrough that could lead to new drugs for #chordoma — a rare #BoneCancer that led to the death of his mother. Read more in @theguardian.com ⤵️ www.theguardian.com/science/2025...
theguardian.com
British professor makes ‘thrilling’ breakthrough for cancer that killed his mother
Paul Workman has researched untreatable chordoma for years. Now new technology points towards to a potential drug to beat it
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Chordoma Foundation Labs @cflabsresearch.bsky.social · 16/02/2025
Crucial building blocks for drugging TBXT (brachyury) published by @ox.ac.uk @icr.ac.uk @uncchapelhill.bsky.social team including crystal structure, discovery of ligandable pockets, and compounds that could serve as starting points for inhibitors or degraders www.nature.com/articles/s41...
nature.com
Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy - Nature Communications
This study describes structures of the transcription factor brachyury revealing the mechanism of DNA recognition. They identify fragments using X-ray fragment screening and optimize these into potent ...
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Reposted by Chordoma Foundation Labs
Chordoma Foundation Labs @cflabsresearch.bsky.social · 10/01/2025
#chemsky & #compchem peeps, we need your help drugging a difficult target: TBXT (brachyury), a transcription factor critical for our disease, chordoma, and implicated in other cancers. We can offer enabling resources, free SPR analysis and now $500K+ in prizes for TBXT ligands: tbxtchallenge.org
tbxtchallenge.org
TBXT CHALLENGE – Make history in drug discovery
Make history in drug discovery
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Chordoma Foundation Labs @cflabsresearch.bsky.social · 10/01/2025
#chemsky & #compchem peeps, we need your help drugging a difficult target: TBXT (brachyury), a transcription factor critical for our disease, chordoma, and implicated in other cancers. We can offer enabling resources, free SPR analysis and now $500K+ in prizes for TBXT ligands: tbxtchallenge.org
tbxtchallenge.org
TBXT CHALLENGE – Make history in drug discovery
Make history in drug discovery
274
Chordoma Foundation Labs @cflabsresearch.bsky.social · 06/12/2024
Our team recently attended the Connective Tissue Oncology Society (CTOS) annual meeting and presented on three areas of ongoing research in the lab: targeting replication stress, biomarkers of EGFR inhibitor sensitivity, and capabilities to enable TBXT (brachyury) drug discovery. 🧵
chordomafoundation.org
Chordoma Foundation scientists share results at international sarcoma…
This was Chordoma Foundation Labs' first invited oral presentation at a major professional conference, and our two posters won recognition as best in…
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Chordoma Foundation Labs @cflabsresearch.bsky.social · 19/11/2024
Nice work from @dkfz.bsky.social defining TBXT regulome.
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Chordoma Foundation Labs @cflabsresearch.bsky.social · 19/11/2024
Building on recent findings that GPX4 is a genetic essentiality in chordoma, we’ve demonstrated that GPX4 inhibition induces ferroptotic cell death, suggesting #ferroptosis susceptibility may be a targetable vulnerability in chordoma. Results now on Figshare: figshare.com/articles/fig...
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Chordoma Foundation Labs @cflabsresearch.bsky.social · 17/11/2024
Confirmed our recent observation of synergism between gemcitabine and ATR inhibition in two additional cell lines, latest data now on Figshare figshare.com/articles/fig...
figshare.com
Gemcitabine and ATR inhibitor synergism and effects on the cell cycle and DNA damage in CH22 and U-CH17PII (Batch 2)
(A.) Treatment regime diagram. Cells were treated in 4 groups. Treatment additions are represented as colored circles. Combination treatment additions were administered 24 hours after the first treatm...
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Chordoma Foundation Labs @cflabsresearch.bsky.social · 23/08/2024
We're studying replication stress in chordoma, and have recently identified several therapeutic approaches that exploit this vulnerability. Here are 3 new figures we’ve put on Figshare to enable others to build on our findings before they’re published. 👇
Chordoma cells stained with DAPI and Gamma-H2AX
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Chordoma Foundation Labs @cflabsresearch.bsky.social · 23/08/2024
Hi! We're joining @bsky.app from Twitter. Our feed there is at x.com/CFLabsResearch. We're here to share recent developments from our lab and from the broader chordoma research field, as well as to connect with and learn from others with overlapping research interests/expertise.
x.com
x.com
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