Author summary Large-scale datasets of multiple genome sequences from a single species are increasingly available. Computer simulations of complex population genetic models are essential for making se...

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Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...

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We are recruiting Faculty microbiologists in three (3) different, complementary, and collaborative areas at the University of Pittsburgh associated with the School of Medicine. 1) Fundamental researc...

Following up on yesterday’s whinesplaining about the relative difficulty of getting a NIH grant across pertinent career eras, I had some more thoughts on generational expectations and gasligh…

Author summary Sodium azide is frequently used as a mutagen for experimental studies in plants. It induces primarily C → T changes. We find that these most often occur when a cytosine (C) is followed ...

How the administration is breaking the government, and what that means for all of us.

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An important aim of population genetics is to elucidate the processes affecting genetic diversity across regions of the genome and across species. Canonical population genetic models of sexually repro...

The number K of mutations identifiable in a sample of n sequences from a large population is one of the most important summary statistics in population genetics and is ubiquitous in the analysis of DN...

Hu et al. (Science, 2023) recently inferred a severe ancient bottleneck around 900 thousand years (kya) ago in African ancestry but found no similar eviden

Bacteriophages are the most abundant and phylogenetically diverse biological entities on Earth, yet the ecological mechanisms that sustain this extraordinary diversity remain unclear. In this study, w...

Temperature is a universal environmental constraint and organisms have evolved diverse mechanisms of thermotolerance. A central feature of thermophiles relative to mesophiles is a universal shift in p...

Plasmids spread important traits in microbiomes but impose fitness costs on their hosts. This study of the ecological consequences of plasmid-bacterial compensatory evolution reveals benefits to bacte...

Hybrids have complex genomes that influence their adaptive potential. This study reveals that yeast hybrids adapt slower than their parental species in a new environment, primarily due to a reduced ra...

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Abstract. With the rise of high-throughput sequencing technologies, a holistic view of genetic variation within populations—through population genomics stu