An encyclopedia of more than 92 million enhancer–gene regulatory interactions created as part of the ENCODE4 project provides a valuable resource for future studies of gene regulation and human geneti...

Approaches combining genetic association and Perturb-seq data that link genetic variants to functional programs to traits are described.

Young researchers are choosing between staying in science and staying in the United States.

Although sometimes overlooked, storytelling is a powerful tool for communicating scientific research. In this World View, Julia Bauman outlines what is needed to convey a strong scientific narrative, ...

AACR Statement and Call to Action Regarding the Administration’s Recent Actions Affecting NIH and the American People

By the authority vested in me as President by the Constitution and the laws of the United States of America, it is hereby ordered:

Spend 5 minutes. Make 5 calls. Make your voice heard.

Prion disease is caused by misfolding of the prion protein (PrP) into pathogenic self-propagating conformations, leading to rapid-onset dementia and death. However, elimination of endogenous PrP halts...

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Dear Senator [name], I am a [title] at [university/company], and I join many of my scientific colleagues in expressing deep concern over RFK Jr.’s nomination for HHS Secretary. I urge you to vote agai...

How does the NIH work and where does it work well?

The CRL4CRBN ubiquitin ligase is leveraged by molecular glue degraders, small molecules that reprogram ligase specificity to induce degradation of clinically relevant neosubstrate proteins. Known CRBN...