The role of mtDNA integrity in muscle progenitor function remains poorly understood. Sen et al. show that mtDNA alterations in myoblasts impair myogenic differentiation and reshape the mitochondrial p...

El autor denuncia el peso creciente de la burocracia en su día a día como investigador. Las sociedades científicas denuncian que hasta el 44% de la jornada se va en tareas administrativas

In the Uspallata Valley, agriculture was adopted by local populations, as evidenced by genetic continuity from earlier hunter-gatherers to farmers; maize-dependent groups from the same regional p...

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As major consumers of cellular metabolites, mitochondria are poised to compete with invading microbes for the nutrients that they need to grow. Whether cells exploit mitochondrial metabolism to protec...

La microbióloga Lynn Margulis pasará a la historia de la biología por haber propuesto la teoría endosimbiótica del origen de las células eucariotas (las que forman el cuerpo de levaduras, […]

Mammals display prominent diversity in the ability to regenerate damaged ear pinna, but the genetic changes underlying the failure of regeneration remain elusive. We performed comparative single-cell ...

Successful skeletal muscle regeneration involves a complex and finely tuned inter-cellular response. Here, by using spatial transcriptomics, the authors identify an intercellular communication axis be...

Summary: We provide an overview of contacts between mitochondria and other membranous organelles, describing the interorganelle tethers involved and the factors that regulate the composition and funct...

The inner mitochondrial membrane forms cristae, which are crucial for mitochondrial function. This Review explores the protein complexes that regulate cristae dynamics, including remodelling and fusio...

The inner mitochondrial membrane forms cristae, which are crucial for mitochondrial function. This Review explores the protein complexes that regulate cristae dynamics, including remodelling and fusio...

Quantitative imaging of the mitochondrial central dogma identifies translation hubs that are suppressed during stress.

Mitochondria serve as central hubs in cellular metabolism by sensing, integrating, and responding to metabolic demands. This integrative function is a…

Dysregulation of stem cell properties is a hallmark of many pathologies, but the dynamic behaviour of stem cells in their microenvironment during disease progression remains poorly understood. Using t...

Adaptations of the Heart: Comparative Responses to Diving and Hypoxia Across Species…Many physiological mechanisms have evolved in living organisms to cope with extreme environments, including high altitudes or deep ocean depths. These include changes in oxygen transport and utilization, metabolic adjustments, strategies to retain heat in cold conditions, adaptations to withstand high pressure, mechanisms for surviving in darkness, and efficient energy use to cope with limited food availability.

The single stranded DNA binding protein RPA plays a pivotal role in DNA replication. The archaeal RPA hosts a WH domain that interacts with the DNA primase and the replicative polymerase PolD. Here th...