Sign in

Markel Martínez-Carranza

@markelmc.bsky.social
691 followers 1.2K following 7 posts

CNRS Researcher @ Pasteur Institute - Structural Biology - interested in archaeal DNA replication

PostsRepliesMedia
Reposted by Markel Martínez-Carranza
Oli Clarke @olibclarke.bsky.social · 13/09/2025
This one is a bit of a departure from the usual and definitely a work in progress! We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below. Read on for details... 1/x
2026782
Reposted by Markel Martínez-Carranza
Svetlana Dodonova @dodonova-sveta.bsky.social · 28/10/2025
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️ Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
6345118
Reposted by Markel Martínez-Carranza
Fabai Wu @fabaiwu.bsky.social · 21/10/2025
Glad to share our paper out today @NatureEcoEvo: “Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor”. www.nature.com/articles/s41... #microsky #archaeasky
nature.com
Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor - Nature Ecology & Evolution
Phylogenetic and biochemical analyses show a diversity of components of the DNA replication machinery in different Asgard archaea that contributed to the eukaryotic DNA replication machinery.
56728
Reposted by Markel Martínez-Carranza
Yifan ZHOU @yifanzhou.bsky.social · 17/10/2025
Our work on viruses and virus satellites of haloarchaea and their DPANN symbionts is out today in Nature Microbiology! @mkrupovic.bsky.social @deemteam.bsky.social @anagtz.bsky.social www.nature.com/articles/s41...
nature.com
Viruses and virus satellites of haloarchaea and their nanosized DPANN symbionts reveal intricate nested interactions - Nature Microbiology
An exploration of the viromes of haloarchaea and their ultra-small DPANN symbionts reveals plasmid-derived satellites of viruses from both archaeal groups, highlighting the complexity of nested symbio...
36326
Reposted by Markel Martínez-Carranza
Svetlana Dodonova @dodonova-sveta.bsky.social · 26/05/2025
We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social! www.biorxiv.org/content/10.1... #Chromatin #Asgard #Archaea #cryoEM
13238101
Reposted by Markel Martínez-Carranza
Sol Vendrell @sol-uble.bsky.social · 03/04/2025
So happy to have published my PhD work! What a funky phage, it was a ride. Big thanks to @beatrizbeamud.bsky.social & @jmouradesousa.bsky.social for bringing their expertise into this story. And my mentors @jmghigolab.bsky.social & @dbikard.bsky.social 💪🏼
3255
Markel Martínez-Carranza @markelmc.bsky.social · 17/01/2025
Super happy to see this work finally out in @naturecomms.bsky.social! Great team effort revealing how single-stranded DNA binding protein RPA interacts with the DNA polymerases in the archaeal replisome 🧵(1/4) www.nature.com/articles/s41... @sauguet-lab.bsky.social @pasteur.fr
nature.com
Communication between DNA polymerases and Replication Protein A within the archaeal replisome - Nature Communications
The single stranded DNA binding protein RPA plays a pivotal role in DNA replication. The archaeal RPA hosts a WH domain that interacts with the DNA primase and the replicative polymerase PolD. Here th...
24521
Reposted by Markel Martínez-Carranza
Pedro Dorado-Morales @doradomoralesp.bsky.social · 16/01/2025
Interested in the plasmidverse? Then, don't think twice and join the International Society for Plasmid Biology Virtual Seminars Series. 👇
12428