A U of A team has mapped how the brain’s immune cells drive recovery of nerve protection in multiple sclerosis, offering a new target for drug discovery.

Nature Communications - Microglial states throughout remyelination are incompletely understood. Here, the authors show that microglia form several states during the early stages of remyelination...

Summary: In vitro and in vivo investigations indicate that CSF1 and IL34 may partially regulate the developmental proliferation of microglia in the mouse hippocampus and cortex, but an additional laye...

Dr. Deepak Kaushik, Assistant Professor at the Faculty of Medicine, Memorial University of Newfoundland (MUN, St. John’s, Canada), is currently recruiting MSc/PhD fellows to join a CIHR-funded…

Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…

The mechanisms of neurovascular adaptations underlying stress resilience remain unclear. Here the authors show that the astrocytic endocannabinoid system modulates the blood–brain barrier changes duri...

Background Rehabilitative training is an effective method to promote recovery following spinal cord injury (SCI), with lower training efficacy observed in the chronic stage. The increased training eff...

Oligodendrocyte precursor cells (OPCs) play a multifaceted role in the brain. Here, the authors show that OPCs regulate neuronal metabolism by forming contacts with neuronal somata, facilitating lysos...

The role of microglia in Alzheimer’s disease is debated. This paper shows that homeostatic microglia seed amyloid plaques in early disease stages and activated microglia compact plaques at later stage...