Reposted by Phil Gross, PhD
Research Spotlight💡
A new study shows senescent cells accumulate in lesions and impair #myelin repair—especially with age. Senolytics improved remyelination in younger mice, highlighting #senescence as a key barrier in aging & #MultiplesSclerosis.
www.nature.com/articles/s41467-025-…
nature.com
Senescent-like microglia limit remyelination through the senescence associated secretory phenotype - Nature Communications
The impact of senescent cells on remyelination is unknown. Here, the authors show that treatment with senolytics following demyelination enhances remyelination in young, but not aged mice, and these effects are mediated by senescence-associated secretory phenotype factors including CCL11.
