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Gary Patti

@gjpattij.bsky.social
1K followers 433 following 32 posts

metabophile (muh-tab-uh-fil'): a person obsessed with all things metabolism, metabolomics

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Reposted by Gary Patti
Margarete Diaz Cuadros @mdiazcuadros.bsky.social · 14/09/2026
First preprint from the lab, led by @gabbov.bsky.social! We identify a metabolic bottleneck that helps set the pace of human development: low levels of the redox enzyme GPD1L limit NADH recycling. Boosting GPD1L mimics mouse cells and accelerates development! www.biorxiv.org/content/10.6...
biorxiv.org
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Jenna Norton @jenna-m-norton.bsky.social · 14/08/2026
Of course this RFI drops late on Friday. NIH proposes to stop providing specific scores and instead bin grants into 3 broad categories: most competitive, competitive, not discussed. A score would be calculated but not provided to the PI (or PO). grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-26-088: Request for Information (RFI) on Proposed Changes to Reporting Outcomes from NIH Peer Review
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information (RFI) on Proposed Changes to Reporting Outcomes from NIH Peer Review NOT-OD-26-088. NIH
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Nature Reviews Cancer @natrevcancer.nature.com · 20/02/2026
dlvr.it
Decoding cancer across scales with metabolomics
Nature Reviews Cancer, Published online: 20 February 2026; doi:10.1038/s41568-026-00908-0In this Review, Rowles and Patti present metabolomics workflows to study cancer across scales. They explore the nutrient demands of cancer cells and how those needs can be fulfilled through metabolic interactions within the tumour microenvironment or systemic crosstalk with distant tissues, and discuss the opportunities and challenges of each approach and offer insights into future research directions.
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Max Kozlov @maxkozlov.bsky.social · 22/01/2026
🚨 New from me: Grant review at more than half of NIH's institutes could be frozen by the end of the year. That's because crucial NIH grant-review panels are slated to be empty at those institutes by Jan 2027. A wonky bureaucratic problem with big implications. A short 🧵
nature.com
Exclusive: key NIH review panels due to lose all members by the end of 2026
Thirteen of the agency’s advisory councils, which must review grant applications before funding is awarded, are on track to have no voting members.
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Jeremy Berg @jeremymberg.bsky.social · 20/01/2026
Dr. Mott is very good at her job, amazing work ethic, and thoughtfully protective of Congressional and scientific interests. A real hero, in my view... For background see www.asbmb.org/asbmb-today/...
asbmb.org
Meet Meghan Mott
She’s living proof that policy fellowships are worthy of consideration.
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Jeremy Berg @jeremymberg.bsky.social · 20/01/2026
The conference (agreement between House and Senate) appropriations bill that includes HHS and NIH was released this morning. www.appropriations.senate.gov/news/majorit... 1/5
appropriations.senate.gov
Committee Releases Conferenced Defense, Homeland Security, Labor, Health and Human Services, Education, and Related Agencies, and Transportation, Housing and Urban Development, and Related Agencies Bi...
United States Senate Committee on Appropriations
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Jeremy Berg @jeremymberg.bsky.social · 28/12/2025
This is an outstanding essay describing some of the important roles and influences of NIH program officers (from an insider perspective). Read! elizabethginexi.substack.com/p/the-quiet-...
elizabethginexi.substack.com
The Quiet Power of Program Officers
How invisible decisions shape what science gets done—and whether it matters
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Yamuna Krishnan @krishnanyamuna.bsky.social · 17/12/2025
Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
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Drug Monkey @drugmonkey.bsky.social · 03/12/2025
There is apparently no point in checking out the "preview" to get ahead of the Biosketch game because it warns you that everything you fill in will be lost and you will have to start over when the real thing is rolled out. grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-26-018: NIHs Implementation of Common Forms for Biographical Sketch and Current and Pending (Other) Support for Due Dates on or after January 25, 2026
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: NIHs Implementation of Common Forms for Biographical Sketch and Current and Pending (Other) Support for Due Dates on or...
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Drug Monkey @drugmonkey.bsky.social · 24/11/2025
Confirmation of the new triage line at 65-70% of proposals. Introduction of a new “competitive but ND” class to permit exception pay pickups.
Details on altered peer review including the new triage line for 65-70% of apps.
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Roland Hatzenpichler @environmicrobio.bsky.social · 14/11/2025
“The prohibited activities would include joint research, co-authorship on papers, and advising a foreign graduate student or postdoctoral fellow. The language is retroactive, meaning any interactions during the previous 5 years could make a scientist ineligible for future federal funding.”
science.org
U.S. Congress considers sweeping ban on Chinese collaborations
Researchers speak out against proposal that would bar funding for U.S. scientists working with Chinese partners or training Chinese students
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Waggoner Lab @labwaggoner.bsky.social · 30/10/2025
Gut microbiota protect against hepatic steatosis by degrading sorbitol derived from dietary glucose @gjpattij.bsky.social www.science.org/doi/10.1126/...
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Your Local Epidemiologist @ylepidemiologist.bsky.social · 21/10/2025
6/ So what can you do? ✔️ Choose supplements that are third-party tested for heavy metals (USP, NSF, or Informed Sport). ✔️ Prioritize whole-food protein sources when possible. ✔️ Advocate for stronger supplement regulation as the industry has little oversight.
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Artem Khan @artemakhan.bsky.social · 11/10/2025
Excited to share our work on discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine biosynthesis. @cp-cellmetabolism.bsky.social www.cell.com/cell-metabol...
cell.com
Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis
Khan et al. apply machine learning to identify substrates of UNC93A, SLC45A4, and SLC25A45. Biochemical assays and in vivo metabolite tracing establish SLC25A45 as a key mediator of mitochondrial impo...
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Your Local Epidemiologist @ylepidemiologist.bsky.social · 25/09/2025
1/ RFK Jr.’s promised autism “report” landed this week. Instead of new science, we got headlines, a press conference, and far-reaching claims drawn from decades of existing research. Parents and pregnant people were left with overwhelming anxiety. Here’s what the evidence actually says 👇
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Gary Patti @gjpattij.bsky.social · 25/09/2025
The Washington Post did a great job of summarizing a complex topic. There is still so much to learn about the connections between the exposome and cancer. Thanks for including me.
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Nature Portfolio @natureportfolio.nature.com · 14/09/2025
Research in Scientific Reports suggests that blue-throated macaws can learn new actions by watching other macaws interact. The study indicates that this approach to learning is not exclusive to humans. go.nature.com/4g8p43m 🧪
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Caroline Bartman @cbartman.bsky.social · 26/08/2025
defunding children's brain cancer research. @endpts.com
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Jeremy Berg @jeremymberg.bsky.social · 14/08/2025
I have a first serious attempt to estimate the consequences of multi-year funding for July. For new R01s, the amount of additional expenditure was $135 M The number of additional R01s that could have been funded is 182 1/9
media.tenor.com
a man in a shirt and tie is touching his forehead
ALT: a man in a shirt and tie is touching his forehead
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Ian L Morgan @ianlmorgan.bsky.social · 31/07/2025
Here are some of the highlights of the appropriations bill that the Senate appropriations committee just approved: $48.7 billion for NIH, an increase of $400 million Rejects the proposal to cap indirect cost rates at 15% Includes a provision to prevent MYF that would reduce the number of grants
appropriations.senate.gov
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Ian L Morgan @ianlmorgan.bsky.social · 29/07/2025
Even with flat funding for the NIH, under the current FY26 plan, there will be 60% less cancer research and much less research funded overall. We need to make sure Congress understands these tricks and protects against them in their budget plan.
science.org
Odds of winning NIH grants plummet as new funding policy and spending delays bite
Funding multiyear grants up front will sharply cut number of investigators receiving awards
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Your Local Epidemiologist @ylepidemiologist.bsky.social · 23/07/2025
1/ Since January, over 5,500 NIH-funded projects have been paused. That includes cancer trials, Alzheimer’s research, maternal health studies. This is work that directly impacts our lives. And people aren't talking about it enough. Let’s fix that 🧵
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Mike Goodwin @massspecpro.bsky.social · 12/06/2025
RIP Alan Marshall, one of the greatest mass spectrometrists ever, and a great human to boot. nationalmaglab.org/careers/meet...
nationalmaglab.org
Alan Marshall: A scientist and a Gentleman - MagLab
Meet one of the greatest innovators in the history of mass spectrometry, hard at work.
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Jeremy Berg @jeremymberg.bsky.social · 01/06/2025
Join ‪‪@drwendieberg.bsky.social‬ for this half hour of discussion of supplemental breast cancer screening for women with dense breast tissue.
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Eric Topol @erictopol.bsky.social · 31/05/2025
"Gold standard science"
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Randall Munroe @xkcd.com · 29/05/2025
Mass Spec xkcd.com/3094/
[Person with ponytail wearing lab coat hands balloon to another person in front of a springboard, a magnet hanging from above, and then a target] PERSON WITH PONYTAIL to Person 2: Rub this balloon against your head, then go jump past that magnet toward the target on the wall. [caption] Before the bathroom scale was invented, the only way to weigh people was mass spectrometry.
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John Yates @jyates.bsky.social · 30/05/2025
Here’s what we have going on at #ASMS2025
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Jeremy Berg @jeremymberg.bsky.social · 25/05/2025
A strong statement about the importance of NIH on @cbsnews.com.web.brid.gy Sunday Morning (Part 1)
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Eric Topol @erictopol.bsky.social · 25/05/2025
"Protein may be hot, but it’s fiber that Americans need to eat a lot more of." "To get the full health benefits of fiber, it’s important to eat a variety of naturally fiber-rich foods and not rely on supplements...could actually lead to health problems..." gift link www.wsj.com/health/welln...
wsj.com
Americans Don’t Eat Enough Fiber. Here’s Why That Worries Nutrition Experts
The latest science suggests our fiber-poor diets trigger inflammation and contribute to a range of related diseases.
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Jeremy Berg @jeremymberg.bsky.social · 22/05/2025
Video from the hearing yesterday www.youtube.com/live/_Szx0jJ...
youtube.com
Senate Democrats Host Forum on HHS: Day 2
YouTube video by Senator Peter Welch
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Jeremy Berg @jeremymberg.bsky.social · 15/05/2025
Another good use of 5 minutes of your time.
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Jeremy Berg @jeremymberg.bsky.social · 07/05/2025
I have previously posted about the slow issuance of NIH award in fiscal year 2025 compared to fiscal year 2024. jeremymberg.github.io/jeremyberg.g... These data were across all of the institutes and centers at NIH. The results can be examined for each institute and center. 1/n
jeremymberg.github.io
NIH_since_1_20_25
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Phillip White @phillipjwhitephd.bsky.social · 01/05/2025
The Sable Award lecture at METPHYS2025 was really remarkable! Tremendous congratulations to this years exceptional member of our community Kivanc Birsoy
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Dr. Lucky Tran @luckytran.com · 28/04/2025
Deaths from heart disease down 75%, that’s NIH. Deaths from stroke down 75%, that’s NIH. HIV/AIDS no longer a death sentence, that’s NIH. 99% of FDA approved drugs in the last decade, that’s NIH. Please show this video to anyone who doesn’t understand why the NIH is so important.
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Lydia Lynch @lydialynch.bsky.social · 24/04/2025
A beautiful day in Princeton @princeton.bsky.social to host our Ludwig Distinguished speaker Dr Kivanc Birsoy from Rockefeller @ludwigcancer.bsky.social
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Ardem Patapoutian @ardemp.bskyverified.social · 25/04/2025
Here’s your chance to ask the new NIH director some questions. Don’t be shy!
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William C Phelps, PhD @wcphelps.bsky.social · 20/04/2025
A compelling letter from Nobel Laureate, William Kaelin, MD about the looming loss of US leadership in science and innovation. 🧪 www.amjmed.com/article/S000...
amjmed.com
Killing the Science Golden Goose
In the 1970’s I was probably one of the last American high school students who was told that if you wanted to go to medical school, you should learn to speak German. This was because in the late 19th ...
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Jeremy Berg @jeremymberg.bsky.social · 19/04/2025
STAT story about freezing all payments to Columbia, Harvard, Brown, Northwestern, Cornell, and Cornell-Weill Medicine. www.statnews.com/2025/04/18/n...
statnews.com
NIH said to have halted awarding of new grants to top universities
Universities whose NIH funding has been frozen may face further strain as the agency holds off awarding new grants to at least a half dozen of them, according to an internal email.
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Jeremy Berg @jeremymberg.bsky.social · 17/04/2025
Inside High Ed article about Advisory Council meetings resuming. www.insidehighered.com/news/governm... 1/n
insidehighered.com
NIH Resumes Key Grant Review Panels
After a months-long pause, advisory councils for the National Institutes of Health are restarting, paving the way for the final approval of grants. Experts say it’s an encouraging sign for the $47 bil...
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Jeremy Berg @jeremymberg.bsky.social · 16/04/2025
Here is a key paragraph: The proposal would reduce the more than $47 billion budget of the NIH to $27 billion — a roughly 40 percent cut. It would consolidate NIH’s 27 institutes and centers into just eight. 2/n
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Jeremy Berg @jeremymberg.bsky.social · 16/04/2025
More from the Washington Post (and this one is a doozy) regarding the President's Budget. Note that this is an aspirational document and Congress has to act (or ignore it). [Gift Link] wapo.st/42gLz0Z 1/n
wapo.st
Internal budget document reveals extent of Trump’s proposed health cuts
HHS would be asked to absorb a $40 billion cut, about one-third of its discretionary budget.
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Magdalena Skipper @magdalenaskipper.bsky.social · 11/04/2025
Airborne microplastics enter plant leaves & end up in our food New evidence emerges for a previously overlooked route for microplastics to enter plant tissues & crops and has implications for ecology and human health Original work www.nature.com/articles/s41... 🧪 www.nature.com/articles/d41...
nature.com
Airborne microplastics enter plant leaves and end up in our food
Evidence for a previously overlooked route for microplastics to enter crops and reach plant tissues has implications for ecology and human health.
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Susanne Ahmari @ahmarilab.bsky.social · 09/04/2025
🚨🚨🚨 Now ALL GRANTS to Columbia are being frozen!!! 🚨🚨🚨 www.science.org/content/arti...
science.org
NIH freezes all research grants to Columbia University
Amid negotiations with Trump, the university could risk losing nearly $700 million
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Magdalena Skipper @magdalenaskipper.bsky.social · 08/04/2025
Science’s big problem is a loss of influence, not a loss of trust, argue Heidi Larson and David Bersoff Science & scientists remain highly trusted. But genuine scientific voices are not shouting loud enough over the noise to hold sway 🧪 #AcademicSky www.nature.com/articles/d41...
nature.com
Science’s big problem is a loss of influence, not a loss of trust
Evidence shows that science and scientists remain highly trusted. But genuine scientific voices are not shouting loud enough over the noise to hold sway.
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Nikolai Slavov @slavov-n.bsky.social · 24/03/2025
NIH contributed to 354 of 356 drugs (99.4%) approved from 2010 to 2019.
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Eric Topol @erictopol.bsky.social · 23/03/2025
A pie graph worth keeping in mind as the NIH budget plummets jamanetwork.com/journals/jam... for 356 new FDA drugs approved
graph of NIH basisfor new drugs
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vaneykj.bsky.social @vaneykj.bsky.social · 22/03/2025
theanalyticalscientist.com/business-edu.... Well said.
theanalyticalscientist.com
The Diminishing of American Science
If US laboratories will have less money to pay staff, conduct research, and collaborate American science will be greatly diminished
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Bini Ramachandran @itsbinir.bsky.social · 22/03/2025
"The changes the current government is attempting to make to American science will greatly diminish our scientific standing in the world." Guess no questions there.. Period..
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The Francis Crick Institute @crick.ac.uk · 19/03/2025
Researchers at the Crick have found that pregnancy in mice leads to the irreversible growth of their small intestine. www.crick.ac.uk/news/2025-03...
crick.ac.uk
Pregnancy irreversibly remodels the mouse intestine
Researchers at the Francis Crick Institute have found that the small intestine grows in response to pregnancy in mice. This partially irreversible change may help mice support a pregnancy and prepare ...
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Gary Patti @gjpattij.bsky.social · 19/03/2025
Thank you for the highlight!
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