Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.

Institut für Klinische Biochemie und Pathobiochemie (Direktor: Univ.-Prof. Dr. rer. nat. Hadi Al-Hasani), Nachwuchsforschungsgruppe Crosstalk (Leiterin: Melanie Mittenbühler, Dr.) (25019)

Harhai and collaborators expand the catalog of genes essential for oxidative phosphorylation and implicate FAM136A in mitochondrial proteostasis. Their findings suggest a mitochondrial contribution to...

Essverhalten: Schon der Geruch von Essen kann das Sättigungsgefühl auslösen – zeigen Forschende am Max-Planck-Institut. Bei Übergewicht scheint dieser Mechanismus gestört zu sein.

Nature Communications - Thermogenesis by brown adipose tissue has long been thought to be solely controlled by uncoupling protein 1 (UCP1). Here, the authors show that energy expenditure in brown...

Short-term transition to high-fat diet (HFD) feeding causes rapid changes in the molecular architecture of the blood-brain barrier (BBB), BBB permeabi…

Nature Biotechnology - An open letter to graduate students and other procrastinators: it’s time to write

Dumesic et al. identify RBM43 as an RNA-binding protein that governs mitochondrial biogenesis through suppression of PGC1α translation. RBM43 is induced by inflammatory signaling and controls a diabetogenic regulatory axis in adipocytes whereby decreased…

Sprenger et al. used a systematic approach to identify how mitochondria remodel their metabolome in response to exercise. The diet-derived, atypical amino acid ergothioneine (EGT) accumulates in muscle mitochondria with exercise training. EGT binds to and…

Sprenger et al. used a systematic approach to identify how mitochondria remodel their metabolome in response to exercise. The diet-derived, atypical amino acid ergothioneine (EGT) accumulates in muscl...

A job-opening of the German Diabetes-Center (DDZ). (24681)

A deep mapping of the human zinc-binding cysteine proteome (ZnCPT) defines thousands of zinc-binding protein cysteines across major domains of biology and discovers glutathione reductase as zinc-targetable cancer vulnerability.

High-resolution structures of respiratory I:III2 complexes from brown fat adapted to cold temperatures reveal a distinct supercomplex assembly with rotated CIII2 that displays higher electron transfer...

Communication between tissues or different cells within a tissue is often a result of secreted molecules such as metabolites, lipids, nucleic acids, o…