ALT: a close up of a human eye with brown eyes

Objectives To assess the impact of skin tone on the measurement and diagnostic accuracy of five fingertip pulse oximeters used by patients in the NHS (National Health Service) England COVID Oximetry {...

This meta-analysis updates a previous meta-analysis examining the association of seasonal influenza vaccination with prevention of adverse cardiovascular events for a new large clinical trial.

The National Confidential Enquiry into Patient Outcome and Death (NCEPOD) reviews clinical practice and identifies potentially remediable factors in the practice of patient care.

Women, children and elderly people among at least 24 killed by attack that turned beach spot into scene of carnage

Decision-making about drugs in pregnancy can be very difficult. Our illogical aversion to clinical trials in pregnancy means people making particularly complex…

Few patients will be eligible for the drugs. Better food regulation and social policy are far more likely to give lasting results, says GP Helen Salisbury

Firearm-related injury is now the leading cause of death among children and teens. We continue to fail to protect our youth from a preventable cause of death.

Background The optimal time for initiating kidney replacement therapy (KRT) in acute kidney injury (AKI) has been extensively studied in recent years. In contrast, there are currently insufficient dat...

Gross et al. show that Atg13 and Atg17 are dispensable for pexophagy during phosphate starvation in yeast. Instead, the metabolite sensor Pho81 binds the Atg1 kinase complex via Atg11 to promote Atg11...

This survey aims to understand which problems affecting the timeliness of emergency laparotomy surgery should be prioritised for improvement. This is part of a larger project that aims to streamline c...

Immune checkpoint inhibitors (ICIs) have become the standard of care for numerous malignancies. Emerging evidence suggests that the time of day (ToD) of ICI administration could impact the outcomes of...

Believed for a long time to be merely a waste product of cell metabolism, lactate is now considered a molecule with several roles, having metabolic and signalling functions together with a new, recent...

Septic shock is characterized by an excessive inflammatory response depicted in a cytokine storm that results from invasive bacterial, fungi, protozoa, and viral infections. Non-canonical inflammasome...