iiinova — where your digital self keeps evolving

Jo Poole @jopodr.bsky.social · 10/07/2025

Ha! Yes I’m thrilled eviction happened prior to this heat wave it was unacceptable!

Jo Poole @jopodr.bsky.social · 10/07/2025

#child#2 is earthside 🥰💕

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Jo Poole @jopodr.bsky.social · 04/07/2025

I think for Colin alone 9/10

Infectious Diseases @infectiousdz.bsky.social · 04/07/2025

Reposted by Jo Poole

What if something quick and free could cut your heart attack risk by 34%? Getting a flu vaccine each year is linked to a 34% lower risk of major cardiovascular events. jamanetwork.com/journals/jam...

jamanetwork.com

Influenza Vaccination and Cardiovascular Risk

This meta-analysis updates a previous meta-analysis examining the association of seasonal influenza vaccination with prevention of adverse cardiovascular events for a new large clinical trial.

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Reposted by Jo Poole

Luke Austen @lukeausten.bsky.social · 02/07/2025

Use of Intralipid in a Propranolol/Quetiapine induced cardiac arrest - our poster today at #SOA25 Evidence for lipid rescue is (and will likely remain) limited, but it really was an inspiring and uplifting case to have been a part of - ROSC after 76 mins CPR and an excellent neurological outcome.

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Jo Poole @jopodr.bsky.social · 03/07/2025

Comes - there are a lot in AKI

Jo Poole @jopodr.bsky.social · 03/07/2025

I think target trial emulation is an interesting and hypothesis generating method, but I think unless the effect size fairly large, never possible to truly eliminate confounders - I’d also like to see trials start to enrich the likely responders using biomarkers that correlate with functional out

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Reposted by Jo Poole

Shaun Lintern @shaunlintern.bsky.social · 03/07/2025

My family had a recent experience of hospital care & we saw effect of this type of taskification of care. Pointless delays, miscommunication, unnecessary referrals etc. No one had the patient at the core of their thinking as they did their bit of the job - result was real anguish

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Jo Poole @jopodr.bsky.social · 02/07/2025

Not all airway compromises would be safe to travel - many of ours done for dental extractions - not sure our network tertiary centre would manage all of those! Huge increased rate since less nhs dentists too

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Jo Poole @jopodr.bsky.social · 01/07/2025

In an ideal world there should be a level 1.5 care for such patients, but when bed bases often limited for level 2 and 3 care, is it justifiable to take patients for enhanced monitoring etc only? It’s not a straight forward situ

Max Kozlov @maxkozlov.bsky.social · 30/06/2025

Reposted by Jo Poole

These cuts come as high-ranking US officials criticize top journals as ‘woke’ and ‘corrupt’. In May, RFK Jr threatened to bar government scientists from publishing in top medical journals. And several journals received letters in April from DOJ alleging political bias in the research they publish.

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Reposted by Jo Poole

Ilan Schwartz @germhuntermd.bsky.social · 01/07/2025

Once again, this is why we cannot ask pregnant trainees / early career faculty to attend scientific & medical conferences in states that outlaw abortion, and hence why we absolutely must not hold conferences in these states

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Reposted by Jo Poole

Segun Olusanya (He/Him) @drfreeze.bsky.social · 01/07/2025

Mervyn’s suggestions for the next stages of critical care #soa25

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Segun Olusanya (He/Him) @drfreeze.bsky.social · 01/07/2025

Next up: Professor Rockwood (yes, THAT Rockwood) discusses frailty And here’s his definition #soa25

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Reposted by Jo Poole

Aoife Abbey 📟 🩺 ⚕️ @whistlingdixie.bsky.social · 01/07/2025

Honestly could have fed Prof Rockwood Questions for an hour!what a fantastic and relevant session on Frailty #SOA25

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Jo Poole @jopodr.bsky.social · 01/07/2025

At some point we have to decide what we stand for - is human life, let alone innocent child life, worth nothing?

Jo Poole @jopodr.bsky.social · 01/07/2025

These are war crimes, missile attacks in areas full of defenceless civilians and children are pathetic - why is there so much inaction on the atrocities being committed by the IDF? We wouldn’t tolerate other nations doing this? www.theguardian.com/world/2025/j...

theguardian.com

Witnesses describe grim aftermath of Israeli strike on busy Gaza cafe

Women, children and elderly people among at least 24 killed by attack that turned beach spot into scene of carnage

josh farkas 💊 @pulmcrit.bsky.social · 28/06/2025

Reposted by Jo Poole

the volume of an ellipsoid is ABC/2 so if a patient is in hemorrhagic shock with an 3x4x5 cm hematoma in their abdomen, the hematoma *cannot* explain their hemorrhagic shock (estimated 30 cc volume) keep looking for the source of bleeding (which statistically is likely to be a GI bleed) #EMIMCC

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No we don’t? That’s why it’s being collected? Why’s that a bad thing? I’m just cautious having seen a few is all, I don’t have a problem with their licensed indication but I’m glad we have monitoring schemes to check these events for us

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I actually completely disagree with you on both these counts, I don’t think we can safely say there is not an increased risk of pancreatitis, furthermore the mechanism is very clear - they work very particularly on pancreatic hormone and metabolic regulation….

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I think the whole point of follow up data is to identify what the rates actually are and potentially identify who is higher risk. Like with the expansion of any medication, one sees more unusual complications the wider the roll out. That’s just good monitoring policy and not isolated to these jabs

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It’s just bizarre really that’s super depressing

And we are extrapolating if we give to people beyond those inclusion criteria, that’s all. It’s about balancing treatment for miserable chronic obesity and then also doing no harm.

As the numbers roll out and increase, so will rarer side effects. Again it doesn’t mean we shouldn’t use them, but I think the idea that they’re “very safe” isn’t also true - trials were done in a subcategory of obesity

There are other things we are just learning - their effect on oral contraceptive efficacy, the effect on gastric emptying leading anaesthetic societies to consider different airway protection during surgery

I only see the sickest patients, but we have had some really nasty pancreatitis, euglycaemic keto acidosis, hypoglycaemias ending up on organ support - we can’t prevent people eating or training badly but since we can licence meds we should just be aware

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I used to think only a win but I’ve seen a few end up in intensive care recently and I think we should continue to monitor who is at the higher end of harm - like all things they’re generally safe but within that cohort some are developing fatal complications so we should continue to investigate why

It’s not about not using them, they’re a phenomenal innovation, it’s just the wider medical community being aware of an uptick in other side effects and forms of abuse, like any medication.

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Non obese individuals being prescribed them by online pharmacies (because they’re lucrative), or those with eating disorders trying to inject them more frequently/higher dose than they should be leading to serious and life threatening illness (and sight loss!)

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We have actually caused harm as a medical community many times in the past, valproate and thalidomide being good examples. I see nothing wrong with continuing to gather data on side effects, or indeed an ongoing study looking at genetic risk profiles for these meds, as they are expanded

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