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Jo Carpenter

@jocarpenter.bsky.social
551 followers 464 following 40 posts

✨Maps and memories✨ hippocampal-entorhinal electrophysiologist Moser & Dunn Groups • KISN Norway

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Jo Carpenter @jocarpenter.bsky.social · 07/07/2026
The Moser Group is presenting our work on Wednesday afternoon at #FENS2026! •Mechanism for L-R sweeps •Attention modulation of sweeps •Grid/place remapping rules & dynamics •”Mega torus” as a hi-capacity memory space •Moving the grid bump •Development of tori & rings •RSC/HC pops. in a spatial task
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Jo Carpenter @jocarpenter.bsky.social · 11/03/2026
Toroidal manifolds abruptly emerge at P10 in rat pups! 🤪🍩 Several days later, space is *gradually* anchored to these tori when the puppachino actively navigates Congrats to the big boss @matteoguardamagna.bsky.social 🤠
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Christine Grienberger @cgrienberger.bsky.social · 17/02/2026
🚀 New preprint from the lab! Our first foray into the subiculum uses in vivo whole-cell recordings to show that dendritic plateaus are a prominent, learning-dependent signaling mode of subicular neurons. Feedback is welcome! www.biorxiv.org/content/10.6...
biorxiv.org
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Amar Sahay @amarsahay.bsky.social · 12/02/2026
Excited to share our study in Neuron led by @travisgoode.bsky.social, a K99 PDF (interviewing for Faculty) and Sahay lab team with collaborators at BROAD, Hopkins, and UW Seattle, defining a neural circuit that links prior experience with feeding behavior. Open Access: sahaylab.com/publications
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Horst Obenhaus @octoscience.bsky.social · 23/12/2025
Do you love quantifying animal behavior as much as we do? We have just the tool for you! Presenting #OCTRON - a pipeline that helps you create rich annotation data and enables training of custom segmentation models. Have a look, particularly if you work with non-model / invertebrate organisms!
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Yvette Fisher @yvetteefisher.bsky.social · 15/12/2025
*First preprint from our lab* !!!!! How does the brain learn to anchor its internal sense of direction to the outside world? 🧭 led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman: “Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6... Thread ⬇️
Schematic of how ER-EPG plasticity enables the bump of activity in EPGs to accurately track visual cues. As a fly makes a counter-clockwise turn (top to bottom) it will view visual cues (e.g. the sun) from a new angle and the EPG activity bump (red) will swing clockwise around the network by integrating self motion signals with these visual inputs. When the fly faces a different angle, distinct visual ER neurons are active. Plasticity forms a trough of weak synapses (large circles - strong synapses, small circles - weak synapses) that allow ER neurons with distinct visual tuning to move the EPG bump via disinhibition.
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Corinna Schulz @corcerebrum.bsky.social · 09/12/2025
Your stomach called – your striatum picked up! But does this actually happen in humans? Using simultaneous dopamine PET/fMRI, we show that the gut hormone ghrelin helps the brain adjust motivation to current metabolic need. Here’s what we found👇 Preprint: shorturl.at/pq4A3 #neuroskyence #🩺
Graphical visualization of the research question
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allen institute @alleninstitute.org · 05/12/2025
🧠📢 New preprint alert Large-scale ephys is exploding but spike sorting remains the computational bottleneck. A 2-hr, 6-probe Neuropixels 2.0 Quad Base session can take over a week to sort on a single machine. Here's a better solution. 🧵 #neuroskyence #compneurosky
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Matteo Guardamagna @matteoguardamagna.bsky.social · 18/11/2025
Still at SfN on the last day? During the morning session on the 19th, 8:00AM - 12:00PM, come check out our posters from the Moser, Zong, and Gonzalo Cogno groups in row QQ ('Grid cells and spatially modulated cells'). Ephys, imaging, remapping, development, sweeps and more! 🧠 Detailed thread below 👇
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Jo Carpenter @jocarpenter.bsky.social · 15/11/2025
SFN 2025 let’s gooo!! Moser group posters are held Wednesday morning (QQ), so if you’re leaving early feel free to come find us to chat :)
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Emilie Macé @mace-lab.bsky.social · 11/09/2025
Thrilled to share that our work is now published in Science! ✨ We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭 www.science.org/doi/10.1126/... 🧵1/
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Dan Levenstein @dlevenstein.bsky.social · 07/09/2025
“If everything is everywhere, why have distinct areas? Here we show that the function of a brain area is more related to how different types of information are combined (formatted) in neural representations than merely whether that information is present.”
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Matteo Guardamagna @matteoguardamagna.bsky.social · 12/07/2025
Our collaboration - from PhD work - examining input-specific (EC L3) contributions to rate and temporal coding in CA1 place cells is now out in @natcomms.nature.com 🔬🧠 rdcu.be/evWtz
rdcu.be
Direct entorhinal control of CA1 temporal coding
Nature Communications - Temporal coding in the hippocampus is thought to be key for memory and predictions. Here, the authors show that blocking one entorhinal input affects two aspects of...
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Jerome Beetz @beetzjerome.bsky.social · 14/06/2025
Amazing study: @tamir-eliav.bsky.social from the Ulanovsky lab describes replay events in a large scale environment (200 m tunnel). 🦇 www.cell.com/cell/abstrac...
cell.com
Fragmented replay of very large environments in the hippocampus of bats
Hippocampal replays in bats flying in a 200-m tunnel depict short fragments of long flight trajectories, suggesting constraints on the mechanisms and functions of replay.
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Yipeng Li @moonliyp.bsky.social · 11/05/2025
(1/6) Thrilled to share our triple-N dataset (Non-human Primate Neural Responses to Natural Scenes)! It captures thousands of high-level visual neuron responses in macaques to natural scenes using #Neuropixels.
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Manfredi Castelli @manfredic.bsky.social · 19/03/2025
Check out my preprint on hippocampal ripple diversity, with @vitorlds.bsky.social and David Dupret at the MRC BNDU, where we reveal that distinct CA1 laminar profiles of ripples are associated with different reactivation dynamics: www.biorxiv.org/content/10.1...
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Sarthak Chandra @sarthakc.bsky.social · 19/02/2025
1/ Our paper appeared in @Nature today! www.nature.com/articles/s41... w/ Fiete Lab and @khonamikail.bsky.social . Explains emergence of multiple grid cell modules, w/ excellent match to data! Novel mechanism for applying across vast systems from development to ecosystems. 🧵👇
nature.com
Global modules robustly emerge from local interactions and smooth gradients - Nature
The principle of peak selection is described, by which local interactions and smooth gradients drive self-organization of discrete global modules.
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Dr. Catherine Macdonald @drcatmac.bsky.social · 19/02/2025
Every scientist, long before they were a scientist, was a little kid who stood in front of a fish tank or stared up at the stars or turned over a rock to look at the bugs underneath and said “wow”. On the best days, working in science still feels like that.
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Jo Carpenter @jocarpenter.bsky.social · 03/02/2025
Congratulations Abe and Rich!!
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Lisa Genzel (she/her) @lgenzel.bsky.social · 19/01/2025
We are still taking applications!
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Ipshita Zutshi @ipshitaz.bsky.social · 09/01/2025
It’s an incredible feeling to see something you’ve poured your heart into come to life. This work was born from my curiosity about hippocampal “cognitive tuning.” Our interpretation of the environment depends on our actions, constantly evolving as we pursue our goals www.nature.com/articles/s41...
nature.com
Hippocampal neuronal activity is aligned with action plans - Nature
Using high-density electrophysiological recordings, how internally generated cell assemblies are updated by action plans to meet external goals is explored.
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Misha Ahrens @mishaahrens.bsky.social · 18/12/2024
Our paper on ketamine’s effect on astrocytes and behavior is out in Neuron by Marc Duque, Alex Chen, Eric Hsu, and colleagues @marcduque.bsky.social @alexbchen.bsky.social @ehsu6.bsky.social, with the Engert, Fishman, & Bergles labs, www.sciencedirect.com/science/arti...
sciencedirect.com
Ketamine induces plasticity in a norepinephrine-astroglial circuit to promote behavioral perseverance
Transient exposure to ketamine can trigger lasting changes in behavior and mood. We found that brief ketamine exposure causes long-term suppression of…
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Jo Carpenter @jocarpenter.bsky.social · 14/12/2024
celebrating another year of excellent science, happy animals, and *happy people* at the kavli ❤️✨ @kavlintnu.bsky.social
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Matthias Nau @matthiasnau.bsky.social · 07/12/2024
Do octopuses dream? In any case, can't get enough of watching them sleep 😴🐙 Look at this symphony of patterns and movements! Incredible. youtu.be/006DjAixu9E?...
youtu.be
Do octopuses dream? Brain recordings provide the first clues
YouTube video by nature video
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David Tingley @davidtingley.bsky.social · 05/12/2024
In those animals we didn't observe a correlation between ripples and glucose fluctuations. To me, this strongly suggested pancreatic insulin release is a mechanistic intermediate
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David Tingley @davidtingley.bsky.social · 05/12/2024
Wow, thanks so much Adrien! It was such an exciting project to work on, and many directions to follow up. Another *really hidden gem (it didn't end up in the paper), we (@jocarpenter and I) treated three rats with streptozotocin which effectively kills beta cells in the pancreas...
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andy alexander @andyalexander.bsky.social · 12/11/2024
Awesome pub looking at the unique role of AD- and M2-projecting RSC circuits from Xiaoxiao Lin et al. #neuroskyence www.nature.com/articles/s41...
nature.com
Projection-specific circuits of retrosplenial cortex with differential contributions to spatial cognition - Molecular Psychiatry
Molecular Psychiatry - Projection-specific circuits of retrosplenial cortex with differential contributions to spatial cognition
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Jo Carpenter @jocarpenter.bsky.social · 28/11/2024
Thankful for a loving family, all of my super funny friends, a happy and collaborative lab environment, and my rat Rafael for giving me some beautiful data tonight 🤩🥰🍗
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Adrien Peyrache @apeyrache.bsky.social · 25/11/2024
While this result is really exciting, the paper also contains some hidden gems. Ext Data Fig. 3, for instance, show the power spectrum of ripple occurrence. It reveals that ripple rates fluctuate not only on a 24-hour circadian cycle but also on a 4-hour ultradian cycle. 5/
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Jo Carpenter @jocarpenter.bsky.social · 25/11/2024
Very timely piece. With 3-4 probes per rat and ultra long recordings, I’ve already generated 95TB of data for a single project. Thinking lots these days about how to store and publish all of this… 😬😬 Raw files vs. spike times x behavior or something in between?? Or both?
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Jon Rueckemann @jonrueckemann.bsky.social · 12/11/2024
go.bsky.app/LdtUYZS I created a starter pack for the growing community of hippocampus physiologists that have joined the great migration. Also included the physiology-adjacent. Tell me who I haven’t found yet
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Mark Brandon @markbrandonlab.bsky.social · 22/11/2024
Now out in Neuron! We benchmark place cell models using a massive CA1 dataset—nearly 70,000 rate maps—collected as mice explore environments with different geometries BVC models perform remarkably well, but we hope this dataset/approach becomes a resource for testing/refining place cell models
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Jo Carpenter @jocarpenter.bsky.social · 20/11/2024
This paper adds to a nice list of papers recently that (broadly) merge brain and body biology: The others one are www.biorxiv.org/content/10.1... And www.nature.com/articles/s41...
biorxiv.org
Food intake enhances hippocampal sharp wave-ripples
Effective regulation of energy metabolism is critical for survival. Metabolic control involves various nuclei within the hypothalamus, which receive information about the body’s energy state and coord...
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Charan Ranganath @charan-neuro.bsky.social · 18/11/2024
Super-psyched to share this preprint from my student Yicong (Alan) Zheng: "Recurrent Inhibitory Dynamics in the Entorhinal Cortex Support Pattern Separation" www.biorxiv.org/content/10.1... It's a new biologicaly-based computational model of the entorhinal-hippocampal system. Thread (1/?)
biorxiv.org
Recurrent Inhibitory Dynamics in the Entorhinal Cortex Support Pattern Separation
The entorhinal cortex (EC) provides the major input to the hippocampus (HPC). Numerous computational models on the EC propose that its grid cells serve as a spatial metric, supporting path integration...
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Jo Carpenter @jocarpenter.bsky.social · 24/10/2024
It’s always a fun lab meeting when the prodigal child @Erik_Hermansen1 returns! (booking conference rooms is not our strong suit)
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Jo Carpenter @jocarpenter.bsky.social · 14/10/2024
When you’re unexpectedly in town and all your friends are neuroscientists
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Jo Carpenter @jocarpenter.bsky.social · 11/10/2024
SfN 2024 😍
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Jo Carpenter @jocarpenter.bsky.social · 07/10/2024
Come check out Moser group posters today at SFN!! ❤️We have: NPX, mini2P, recordings across HPC-EC circuit, remapping, ontogeny of torus, sweeps, all-optical stim, time coding, grid cell hot spot maps, LEC, RSC, SUB & minute scale oscillations! 8:00 AM-12:00 PM 190.01-190.11
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Jo Carpenter @jocarpenter.bsky.social · 25/06/2024
At @FENSorg this year? Poster #PS01-26AM-004 (WED) Presenting my work on remapping of neural populations across the HPC-EC circuit using data from 3 simultaneously-recorded Neuropixels 2.0 probes (CA1-MEC/PaS-Sub) in freely moving rats exploring 5 different rooms over 12 hours!
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Jo Carpenter @jocarpenter.bsky.social · 14/04/2023
@MartinBjerke_ presenting his PhD work (with @adric_dunn) using some classic @Drake memes at @kavliYROCK ‘s annual NeuroSys symposium !! 🧠
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Jo Carpenter @jocarpenter.bsky.social · 14/11/2022
pre-presentation sun exposure ☀️ come see our recent work from the Moser group at SFN YY1-YY5 at 1pm today Unpictured: new group leader @soledad_gcogno
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Jo Carpenter @jocarpenter.bsky.social · 12/11/2022
At SFN 2018 in San Diego, I met my future PhD advisors @MayBrittMoser @EdvardMoser and future partner @davidwtingley 🥰 I’m super stoked to be back in my old college town this year to present Part 1 of my PhD work, catch up with old friends, and see some new science !! 🧠
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Jo Carpenter @jocarpenter.bsky.social · 15/02/2022
celebrating successes in the moser lab! congratulations on the acceptance of the miniscopes paper @WikiZong @HorstObenhaus @EmilieSkytoen @NienkeLdeJong @HannaEneqvist @RubenDVale @MayBrittMoser @EdvardMoser and marina 🤩
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Jo Carpenter @jocarpenter.bsky.social · 10/12/2020
congratulations @davidwtingley on an awesome PhD defense! you are a brilliant scientist and the best partner.
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Jo Carpenter @jocarpenter.bsky.social · 30/09/2020
did I just watch a presidential debate or an episode of the real housewives?
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Jo Carpenter @jocarpenter.bsky.social · 20/03/2020
So far, my first year of grad school has consisted of: - moving to a new continent - being in a *very* long distance relationship - being emotionally tested by various physics and math classes - recording some place cells - a global pandemic
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Jo Carpenter @jocarpenter.bsky.social · 11/02/2020
I’m looking for a few comp. neuro papers to discuss with my signal processing buddies that use laplace/fourier transform- any suggestions? Shankar & Howard 2012 is up first :)
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Jo Carpenter @jocarpenter.bsky.social · 02/08/2019
Celebrated my last day in the McNaughton Lab @ucicnlm yesterday. I’d like to extend a big thanks to all members of the group for being supportive colleagues, patient mentors and my best friends. I’ll miss you all dearly. Next stop, Moser Lab @KISNeuro!
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Jo Carpenter @jocarpenter.bsky.social · 18/06/2019
Monkey pool party at our place in Kuta 😂🐒
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Jo Carpenter @jocarpenter.bsky.social · 30/05/2019
Took a slight detour on our way down to Taormina @davidwtingley
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