iiinova — where your digital self keeps evolving

Mark Brandon @markbrandonlab.bsky.social · 17/09/2026

I’m very happy to see this one cross the finish line. Congrats to @rrrozeske.bsky.social and Leonie Runtz for this work! See Rob’s nice thread below! 👇

070

Reposted by Mark Brandon

Neil Burgess @neilburgess10.bsky.social · 01/07/2026

Ever wondered how the hippocampal cognitive map is read-out? @changmin-yu.bsky.social @zilong-ji.bsky.social with Jake & John, show that, during navigation, theta sweeps indicate remembered goal-directions (cf. current/next movements or perceptual targets) 1/2 www.nature.com/articles/s41...

Decoded locations from place cell firing sweep towards a remembered goal location during each theta cycle irrespective of the current movement or head direction

710047

Reposted by Mark Brandon

M Ganesh Kumar @mgkumar138.bsky.social · 19/01/2026

All theory is wrong until verified by data. Greatly indebted to @mhyaghoubi.bsky.social, @markbrandonlab.bsky.social, @douglasresearch.bsky.social for finding the hippocampus encoding reward prediction! Grateful to my advisor @cpehlevan.bsky.social, @kempnerinstitute.bsky.social. #RL #hippocampus

0329

Mark Brandon @markbrandonlab.bsky.social · 14/01/2026

I’m very happy to share the latest from my lab published in @Nature Hippocampal neurons that initially encode reward shift their tuning over the course of days to precede or predict reward. Full text here: rdcu.be/eY5nh

210632

Mark Brandon @markbrandonlab.bsky.social · 27/12/2025

New paper from the lab, now out in @PNASNews tinyurl.com/bdeh2bs8 - ADN neurons (head direction cells) project to MEC inhibitory cells, with a preference for VIP-expressing cells - MEC VIP cells increase cfos expression during, and are required for, a spatial memory task

tinyurl.com

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

092

Mark Brandon @markbrandonlab.bsky.social · 09/04/2025

How good is your place cell model? Come benchmark yours against real data - nearly 70K CA1 rate maps in various geometric shapes across weeks - collected and curated in my lab by the great @jquinnlee.bsky.social and @atkeinath.bsky.social

061

Reposted by Mark Brandon

Adrien Peyrache @apeyrache.bsky.social · 07/04/2025

Congrats Dr Gilberto R Vite! 🎉🍾 Gilberto successfully defended his PhD, on the role of the thalamus in coordinating activity in the entorhinal cortex. Big thanks to his committee, Laura Colgin, @markbrandonlab.bsky.social, Stuart Trenholm, and @sylvainbaillet.bsky.social 🙏🙏

0181

Reposted by Mark Brandon

Hugo Spiers @hugospiers.bsky.social · 12/02/2025

Grateful to @apnews.com for covering our recent @pnas.org article on how London taxi drivers plan routes: apnews.com/video/how-th... #neuroskyence

0334

Reposted by Mark Brandon

Tristan Shuman @tristanshuman.bsky.social · 28/01/2025

New paper out in Cell Reports! Led by @susieyufeng.bsky.social, we found that chronic epilepsy in mice drives distinct synchronization deficits in hippocampus and MEC, with early changes in HPC and late-onset changes in MEC that align with progressive memory impairment. www.cell.com/cell-reports...

Screenshot of article entitled "Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy" by Yu Feng, Keziah S. Diego, Zhe Dong, ..., Nadia N. Khan, Denise J. Cai, and Tristan Shuman.

In brief: Feng et al. demonstrate that memory deficits in temporal lobe epilepsy involve multiple discrete mechanisms with distinct time courses. In epileptic mice, early-onset memory deficits are associated with disrupted hippocampal synchronization, while more severe, lateonset impairments are associated with disrupted synchrony of medial entorhinal cortex circuits.

15321

Reposted by Mark Brandon

Hugo Spiers @hugospiers.bsky.social · 10/01/2025

Here is the MIT Tech Review article covering the data collection linked to this new Phd Opportunity at our new International Centre for NeuroArchitecture and NeuroDesign: www.technologyreview.com/2024/09/13/1...

technologyreview.com

Neuroscientists and architects are using this enormous laboratory to make buildings better

Creating life-size simulations of the real world can reveal how we, and our minds, respond to the environments around us—and could shape the future of architecture.

03212

Reposted by Mark Brandon

Tom George @tomnotgeorge.bsky.social · 25/11/2024

What are the brain’s “real” tuning curves? Our new preprint "SIMPL: Scalable and hassle-free optimisation of neural representations from behaviour” argues that existing techniques for latent variable discovery are lacking. We suggest a much simpl-er way to do things. 1/21🧵

47222

Mark Brandon @markbrandonlab.bsky.social · 22/11/2024

Now out in Neuron! We benchmark place cell models using a massive CA1 dataset—nearly 70,000 rate maps—collected as mice explore environments with different geometries BVC models perform remarkably well, but we hope this dataset/approach becomes a resource for testing/refining place cell models

1239