John Janetzko @jjanetzko.bsky.social · 04/07/2026That’s what I am saying - if you only had the industry part, it would change the dynamic a lot. Or if it was industry funded research labs only - same idea 020
John Janetzko @jjanetzko.bsky.social · 03/07/2026I’m sure they would cite how in Europe people often do PhDs with industry partnerships. The problem is, in isolation that model limits the uptake of new approaches 110
Reposted by John JanetzkoBWJones @bwjones.bsky.social · 03/07/2026When I explain to peeps how much we do in research labs for how few $$, they simply don’t believe me. I once explained it to a famous person from Pixar, he looked me square in the eye and said “You mean all the cancer, vision, and Alzheimer’s grants work that way? You’ve gotta be %#ing kidding me!” 8583179
John Janetzko @jjanetzko.bsky.social · 03/07/2026I’ll also hit the limit of 6 submissions in a year 😢 010
John Janetzko @jjanetzko.bsky.social · 03/07/2026Yes - I have like 10 ongoing projects 🥴 only half have funding directly - the other half are through pilot funds 120
John Janetzko @jjanetzko.bsky.social · 03/07/2026You will have 6 NIH grants, or submissions? Can people in your group even have that many projects?? 110
John Janetzko @jjanetzko.bsky.social · 03/07/2026I have been pretty quiet lately online, but I’m very much looking forward to reengaging with the community here and sharing all of the amazing work in our lab 🙏🏼 010
John Janetzko @jjanetzko.bsky.social · 03/07/2026We also had grants triaged, not discussed, and papers which were rejected. This is life. We learn, we adapt and we always strive to be better. 100
John Janetzko @jjanetzko.bsky.social · 03/07/2026In 2026 we have published 1 paper with a collaborator, and have several more which will be out very soon and I can’t wait to share 100
John Janetzko @jjanetzko.bsky.social · 03/07/2026We have been fortunate to be supported by several sources. A T32, an R00, internal pilots and awards, and the Boettcher foundation. We have other irons in the fire, but in these tough times you take everything you can get! 100
John Janetzko @jjanetzko.bsky.social · 03/07/2026We’re officially into July! Hard to believe it’s been 2 years at @cuanschutz.bsky.social and @cu-bmg.bsky.social A lot has happened - and I am so grateful to my lab who has made coming into work each day such a treat. Kudos to them for the new lab photo design, too. Some highlights 👇🏻 130
Reposted by John JanetzkoDrug Monkey @drugmonkey.bsky.social · 11/03/2026A tomahawk missile costs the taxpayers the same amount of money as one five-year major NIH research grant. Remember that every time they tell us one of those missed the target, blew up paintings of enemy aircraft or tanks, or was the fifth and unnecessary hit on the same target. 5353145
Reposted by John JanetzkoAngelo D’Alessandro @dalessandrolab.bsky.social · 19/11/2025Now out at @cellpress.bsky.social Cell Genomics, we characterized the genetic architecture of the murine red blood cell proteome using omics profiling in 350 genetically diverse mice. The goal was to understand how genetic variation shapes RBC metabolism, redox homeostasis, and storage outcomes. 1/ncell.comGenetic architecture of the murine red blood cell proteome reveals central role of hemoglobin beta cysteine 93 in maintaining redox balanceKeele et al. uncover the genetic architecture of the proteome of fresh and stored red blood cells using a multi-omics analysis of 350 genetically diverse mice. Their work reveals how a hemoglobin redo... 142
Reposted by John JanetzkoJeremy Berg @jeremymberg.bsky.social · 14/11/2025From my perspective, there are many potential problems with this decision. It is likely to disadvantage applications from early stage investigators and for certain classes of proposals. More on this later... 2/13 1274
John Janetzko @jjanetzko.bsky.social · 31/10/2025Well said. Tragic loss for sure. Hope you and everyone there at UCSF are hanging in. 040
John Janetzko @jjanetzko.bsky.social · 31/10/2025@cupharmacology.bsky.social @cu-bmg.bsky.social @cuanschutz.bsky.social 010
John Janetzko @jjanetzko.bsky.social · 31/10/2025I’m crushed. She was such a great human being who stood up for their principles like few others. She will be deeply missed 😢 030
John Janetzko @jjanetzko.bsky.social · 31/10/2025Whoa I’m sorry did I read this right?! No! 😢 this is so horrible. 110
John Janetzko @jjanetzko.bsky.social · 13/10/2025The issue of Molecular Pharmacology edited by @nicoleperryhauser.bsky.social and me is finally finished! As always, it was a joy to work together, and I think we succeeded in compiling some great papers from young GPCR investigators 🤩 Check it out 👇 www.sciencedirect.com/science/arti...sciencedirect.com 030
Reposted by John JanetzkoNicki Perry-Hauser @nicoleperryhauser.bsky.social · 13/10/2025A new special issue entitled “Emerging Voices in GPCR Biology” is now available in Molecular Pharmacology, highlighting innovative research led by early-career investigators (ECIs) across key areas of G protein-coupled receptor (GPCR) science. www.sciencedirect.com/science/arti...sciencedirect.comEmerging Voices in GPCR Biology 146
Reposted by John JanetzkoOded Rechavi @odedrechavi.bsky.social · 04/10/2025Thanking the reviewers 113112
John Janetzko @jjanetzko.bsky.social · 06/09/2025A lab that collects data together stays together. Feeling like the luckiest PI to work with such great folks 🤩🔬 @cuanschutz.bsky.social @cu-bmg.bsky.social 080
Reposted by John JanetzkoCU Anschutz Cancer Center @cucancercenter.bsky.social · 17/08/2025We have new members! Welcome to the CU Cancer Center! 👏 032
Reposted by John JanetzkoJeremy Berg @jeremymberg.bsky.social · 04/08/2025The acknowledgements section speaks to considerable privilege. Without a senior author, he and his classmate were provided with lab space, purified protein, and technical help. Their paper was communicated to PNAS. I doubt many undergraduate researchers have received comparable support. 31/n 1114
John Janetzko @jjanetzko.bsky.social · 29/07/2025Tbf lottery still has to be lower chance, but point is very well taken 120
Reposted by John JanetzkoHarmit Singh Malik @harmitmalik.bsky.social · 29/07/2025With news that NIH grant success rates are now below 5%, consider the effort that goes into one of these grants (apart from you, who submitted 60 AI-written grants)- why would you put in that much effort knowing your chances are only slightly better than winning a lottery? 1/ 810420
Reposted by John JanetzkoArdem Patapoutian @ardemp.bskyverified.social · 22/07/2025No better time to call or email your members of Congress. Next year’s NIH budget is being debated in the Senate. A new nonpartisan campaign is making it easy to defend science and protect America’s innovation. Just follow this link to contact your representatives: www.protectscienceandinnovation.orgprotectscienceandinnovation.orgProtect Science and Innovation 13227
Reposted by John JanetzkoDrug Monkey @drugmonkey.bsky.social · 20/07/2025We are going to hear a lot in the near future about how University brass “has to make hard decisions”. Twill be interesting to see who those hard decisions land upon. 7507
Reposted by John JanetzkoEric Topol @erictopol.bsky.social · 06/07/2025Summary Table of the massive defunding of biomedical research in the United States www.nytimes.com/interactive/... 601545998
Reposted by John JanetzkoJeremy Berg @jeremymberg.bsky.social · 06/07/2025A short Bluetorial about my early days as the Director of the National Institute of General Medical Sciences (NIGMS) at NIH. The importance of feeling responsibility and taking pride in doing the best job you canmedia.tenor.coma cartoon says hey everybody an old man 's talking while bart simpson looks onALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on 525671
John Janetzko @jjanetzko.bsky.social · 27/06/2025Oh no. This is insanity! Hopefully if we do twist the pretzel in 2026 it gets untwisted again in 2028. 010
Reposted by John JanetzkoJay Hesselberth @jayhesselberth.bsky.social · 20/06/2025Excited to see this collaborative work with Olivia Rissland's lab finally out. We found lots of 2A peptides and an entirely new 2A class. www.cell.com/cell-reports...cell.comSystematic identification and characterization of eukaryotic and viral 2A peptide-bond-skipping sequencesRao et al. identified thousands of previously unknown 2A peptides across both viruses and eukaryotes using an HMMER analysis. The authors further identified a unique class of 2A peptides, class B, who... 26822
John Janetzko @jjanetzko.bsky.social · 14/06/2025The world is in chaos, but we still need to rally with our people! Janetzko-Bell lab and friends happy hour to celebrate grant submissions, new additions and scientific accomplishments 🎉 @cu-bmg.bsky.social 051
Reposted by John JanetzkoSen. Cory Booker @booker.senate.gov · 14/06/2025In America, we have no kings. 1382539567
John Janetzko @jjanetzko.bsky.social · 10/06/2025Setting up a lab has been no joke. Today, I'm stoked to have one more piece of my postdoc work out in the wild. Several more manuscripts to go, and I don't have a lot of time for a blue-torial(?) today, but enjoy and happy to get any feedback on this story. www.biorxiv.org/content/10.1...biorxiv.orgMembrane phosphoinositides allosterically tune β-arrestin dynamics to facilitate GPCR core engagementArrestin proteins bind active G protein-coupled receptors (GPCRs) through coordinated protein-protein, protein-phosphate, and protein-lipid interactions to attenuate G protein signaling and promote GP... 2283
John Janetzko @jjanetzko.bsky.social · 07/06/2025Sometimes this job can feel like a lot. But sometimes it’s the best job you could imagine. Your whole lab tells you they want to come in on Saturday to finish an experiment we’ve worked up to and you get to see the look of amazement on your tech’s face when her first negative stain works 😍 070
Reposted by John JanetzkoDr. David Miller 🏳️🌈 @davidimiller.bsky.social · 18/04/2025So: In 2017, Congress made this happen: NIH: Proposed 22% cut --> 9% increase NSF: Proposed 11% cut --> 4% increase NOAA: Proposed 16% cut --> 4% increase Obviously, 2025 is not 2017. A lot is diff now. But still: 💰 Congress, not WH, sets budgets. 📞 Public support & calls to Congress matter. 219699
Reposted by John JanetzkoJason Shepherd @jasonsynaptic.bsky.social · 22/05/2025Oh FFS! This government is self sabotaging the decades long edge America had in recruiting the most talented people from across the world. 2148
John Janetzko @jjanetzko.bsky.social · 22/05/2025Idk about talented but I was on OPT after my PhD 120
Reposted by John JanetzkoEwa Bomba-Warczak @ebomba.bsky.social · 20/05/2025Well, this didn’t age well 👀 0112